Posted on 01/02/2022 5:14:34 PM PST by ConservativeMind
Dementia is thought to occur when proteins accumulate in the brain and form oligomers. Research previously shown that the antibiotic rifampicin removes oligomers from the brain and improves cognitive function. However, the drug has been associated with side effects such as liver damage. Resveratrol, an antioxidant in plants, is used as a supplement. "To combat the negative side effects of rifampicin, we thought of combining it with the hepatoprotective effects of resveratrol," says Professor Tomiyama.
This time, the research group administered a fixed dose combination of rifampicin and resveratrol intranasally five days a week for a total of four weeks to mice models of Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies. The results showed that the combination significantly improved the cognitive function of the mice, inhibited the accumulation of oligomers, and restored synaptophysin levels—presynaptic proteins that facilitate synapses. Additionally, blood levels of liver enzymes, a marker of hepatic damage that normally increases with rifampicin, remained normal in the fixed-dose combination. Furthermore, increased levels of brain-derived neurotrophic factor (BDNF) expression were observed in the hippocampus, which was not seen with rifampicin alone. These results indicate that this fixed-dose combination is superior to rifampicin alone in terms of both safety and efficacy.
Furthermore, based on the team's previous research experience, nasal administration of a fixed dose combination of rifampicin and resveratrol would increase drug transferability to the brain and further enhance both safety and medicinal effects. The dosage used in this study was 0.02 mg of rifampicin per mouse per day, or 1 mg/kg/day assuming a mouse weight of 20g. "Converted to a human dosage based on body surface area, it becomes 0.081 mg/kg/day," says Prof. Tomiyama, "currently, rifampicin is prescribed at 10 mg/kg/day as an antibiotic, and compared to this, we confirmed an effect at a much lower dosage."
(Excerpt) Read more at medicalxpress.com ...
You’d still need to pull it together into a nasal spray, but this combination sounds like an incredible new option to explore for people with a terrible prognosis.
My mom might be a good test subject. But at 92 years old, who really knows the cause of her mental decline.
Pterostilbene is a good alternative to resveratrol; it is very similar in molecular structure but has better bioavailability and longer half-life.
Minocycline might also work as a substitute for rifampicin as they both inhibit microglia activation.
An educated guess would be to find the combination of similarly-acting drugs which would give a long half-life and high bioavailability.
Bttt
I've also heard that drinking alcohol every day helps prevent dementia and Alzheimer's. Unless you drink too much, then it might hurt.
Resveratrol is found in grapes and wine.
Spelled it wrong, dang it! Where’s my nasal spray?
Following
I just this week tried taking Turmeric for my arthritis and a few other things. I had heard so much about it.
After two days, I noticed an intermittent pain in my stomach around the navel. Since Tumeric was the most recent dietary change for me, I presumed that was the cause. I stopped taking the pill.
Even as Tea Powder, I still got pains. So...in the dumper it goes!
Now, I hear there is a fermented form of Tumeric that may be more tolerable for fussy stomach linings like mine.
This now sells for about $18.00 100 caps.
I man try that in a few more days.
If you want to try a truly good turmeric for health benefits, get “Doctor’s Best Curcumin From Turmeric Root with C3 Complex & BioPerine.”
If you have osteoarthritis, there is a completely different supplement I’d suggest.
Thanks for the suggestion, but I’m thinking ‘fermented’ Tumeric is the only kind I would be able to tolerate.
Maybe that brand make fermented T as well.
I’ll be checking it out.
One can buy it at most grocery stores. Several ounces for a few bucks.
Cheaper than health store pills.
I does not dissolve in liquids, has to be stirred and suspended.
I have been taking it for almost 2 years to resolve aches from heavy work...it works.
I’ve read that mouse models have never proved useful for human medication. But I’d try anything at this point...for a loved one.
“rifampicin and resveratrol.” Yes. For sure.
It can be incorporated into many side dishes, too. I make a dish where I sauté mushrooms and onions in butter. I add the turmeric and mix it with the sautéed mushrooms and onions. Then I add cooked rice. It is quite delicious.
Fortunately I found this...
"We have no evidence at this time that there are impacts to public drinking water in the vicinity of the plant. We will continue to monitor and assess the situation. The EPA safe drinking water concentration for tritium is 20,000 picocuries/liter. It is not expected or likely that this concentration would be exceeded as a result of this event. "Private well testing in the vicinity of the plant for tritium is not necessary at this time. We will continue to assess the situation to determine the need as we monitor the situation.
MN State Health: Xcel Energy Monticello Power Plant Tritium Leak
And this...
The article is about dementia and nothing with radioactivity, sir.
Well....
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