If you apply, or have doc apply or prescribe, a shaped piece of a nitroglycerin patch around a recluse bite relatively soon after it occurs it reduces it to just itchy bite. Earlier is better, but works even after it starts getting ugly.
The mechanism that causes the necrosis is a fraction of the venom that causes vasoconstriction and this isolates the area from blood flow which would just dilute and move the bulk out to the liver and other cleaning organs. Putting the patch on dilates the vessels and short circuits the envenomation.
My B.I.L. was like my husband, stubborn about doctors. He said it didn’t hurt when it bit him but started hurting and swelling later that evening. Since he never saw the spider he figured it would be better in the morning. It wasn’t. He waited too long and as soon as the doctor saw it he said Brown Recluse bite and asked him if he’d been digging around in a dark closet without gloves. He said “no, dark garage without gloves.”
Those ED medications are also vasodilators.
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Good information. ThanQ.