Posted on 12/01/2021 8:55:26 PM PST by ConservativeMind
Prevailing theories posit plaques in the brain cause Alzheimer's disease. New UC Riverside research instead points to cells' slowing ability to clean themselves as the likely cause of unhealthy brain buildup.
Along with signs of dementia, doctors make a definitive Alzheimer's diagnosis if they find a combination of two things in the brain: amyloid plaques and neurofibrillary tangles. The plaques are a buildup of amyloid peptides, and the tangles are mostly made of a protein called tau.
"Roughly 20% of people have the plaques, but no signs of dementia," said UCR Chemistry Professor Ryan Julian. "This makes it seem as though the plaques themselves are not the cause."
For this reason, Julian and his colleagues investigated understudied aspects of tau protein. They wanted to understand whether a close examination of tau could reveal more about the mechanism behind the plaques and tangles…
In general, the process of clearing spent or defective proteins from cells, known as autophagy, slows down in people over the age of 65. It isn't clear why, but Julian's laboratory is planning to study this.
Fortunately, drugs are already being tested to improve autophagy. Some candidates include existing drugs approved for cardiovascular disease and other conditions, which may help speed up the approval process.
Autophagy can be induced by fasting. When cells run short on proteins from an individual's diet, they fill the void by recycling proteins already present in cells. Exercise also increases autophagy.
These measures, as well as drug therapies, may ultimately help prevent the disease. "If a slowdown in autophagy is the underlying cause, things that increase it should have the beneficial, opposite effect," Julian said.
(Excerpt) Read more at medicalxpress.com ...
It also helps us understand why a poor diet and lack of exercise seems to help bring on Alzheimer’s.
Reconsider an exercise regimen if your cells produce spike proteins
Or not
Quality sleep is important
BIG PHARMA: Stop spreading misinformation!
Rd later.
.
I think we will be hearing a lot more about Tocotrienols for this disease in the near future.
What does the dot, or period, mean when used as a response to a post? .
Have seen it used several times here on FR, but still don’t know what it means.
Hope it’s too late for FJB.
Often people are just marking the thread to read later.
Bookmark
Drink coffee, skip a meal, take a pill, get vaxxed...
...die of something else sooner.
Win-win.
/s
I was going to say that also. Slow-wave (deep) sleep. That’s when the natural cleaning process occurs.
Some animals, such as dolphins and birds, have the ability to sleep with only one hemisphere of the brain, leaving the other hemisphere awake to carry out normal functions and to remain alert.
I knew there was something different about the daytime "nap" sleep my small parrots experience. It gives the impression that they are asleep yet alert at the same time, can react instantly, but getting the benefit of a nap just the same. This is why.
There was a recent study about the better benefit of
lamb consumption for a more favorable Alzheimer outlook.
I would wonder that a correlation between exercise, BMI, and lamb consumption is also involved in outcomes.
Are certain regions populations more inclined to be
healthier generally because of the three?
Also fasting should be considered for religious groups etc..
Insulin resistance is highly correlated to developing Alzheimer’s.
So much so, that Alzheimer’s has been called Type 3 diabetes.
Both fasting and exercise reduce insulin resistance.
Does this mean that Alzheimers is more prevalent today because of food’s availability 24 hours/day as opposed to past history when food was not readily available? (Run on sentence)
Bookmark for one to come back to a particular article or post.
I do frequent extended fasts. Hopefully that counts.
I’m reading the article as saying that fasting and exercising is harmful.
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