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Over 4 Million Deaths per Year Caused by Obesity: Safe, Non-Invasive Treatments Could Help End Epidemic
SciTechDaily ^ | OCTOBER 26, 2021

Posted on 10/27/2021 12:57:53 PM PDT by nickcarraway

Novel obesity treatments such as modulation of the gut microbiome and gene therapy are underutilized and could help fight the obesity epidemic, according to a new manuscript published in the Endocrine Society’s journal, Endocrine Reviews.

Nearly half of the adults and 20 percent of children in the United States have obesity, yet doctors are under prescribing effective weight loss medications and many patients are not receiving the treatment they need. The weight stigma that exists in healthcare settings makes people with obesity hesitant to seek care until comorbidities develop and reach a dangerous stage. Lack of insurance coverage and cost issues are another factor that creates barriers to obesity treatment.

“Obesity is the epidemic crisis of our time. The disease leads to serious comorbidities such as diabetes, fatty liver disease and cardiovascular disease and significantly shortens a person’s length and quality of life,” said Christos S. Mantzoros, M.D., Sc.D., of Beth Israel Deaconess Medical Center in Boston, Mass. “Until recently we did not understand the genetic and hormonal causes of obesity and how obesity leads to these comorbidities. We have recently started to understand the causes of obesity in humans, which is a big discovery that has led to designing effective therapies.”

In the article, the researchers map out the molecular and hormonal pathways that lead to obesity and the disease’s related comorbidities. This data gives researchers the insights they need to design, test and implement new obesity therapies.

The researchers highlight the need for safer and more effective obesity therapies, including new drug delivery systems, vaccines, modulation of the gut microbiome and gene therapy. Novel medications, including combinations of gastrointestinal hormones and other molecules, are being tested and are expected to lead to significant percentages of weight loss with less side effects once available. As our understanding of obesity improves, more effective medications with fewer side effects will be developed.

Recently approved medications such as semaglutide, a modified gastrointestinal hormone administered once a week, can lead to 15% weight loss when combined with lifestyle changes. Bariatric surgery can lead to up to 40% weight loss, but it is invasive and linked to complications.

“Insurance companies need to pay attention to data from studies and the scientific progress we are making and start covering the medications that are and will be approved soon, given that currently only a small minority of patients with obesity have coverage for the medications and medical care they need,” Mantzoros said. “It would be much more cost effective to cover treatments early instead of waiting for comorbidities and their complications to develop.”

Other authors of the study include: Angeliki Angelidi and Matthew Belanger of Harvard Medical School in Boston, Mass., and Alexander Kokkinos and Chrysi Koliaki of Laiko General Hospital in Athens, Greece. The research received no external funding.

Reference: “Novel Non-invasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy” 26 October 2021, Endocrine Reviews.


TOPICS: Health/Medicine; Science
KEYWORDS: death; health; obesity
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1 posted on 10/27/2021 12:57:53 PM PDT by nickcarraway
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To: nickcarraway

Eat less food, eat healthier food, exercise.


2 posted on 10/27/2021 1:04:14 PM PDT by doug from upland (Why the hell isn't Hillary Rodham Clinton in prison yet?)
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To: nickcarraway

This will be mandated as soon as covid wanes.


3 posted on 10/27/2021 1:04:17 PM PDT by fruser1
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To: nickcarraway
Until recently we did not understand

A line I've heard all my life about things that have turned out later to be wrong

4 posted on 10/27/2021 1:07:05 PM PDT by cmj328 (We live here.)
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To: nickcarraway

Safe, Non-Invasive Treatments called DIETS and EXERCISE Could Help End Epidemic:-)


5 posted on 10/27/2021 1:07:17 PM PDT by Harpotoo (Being a socialist is a lot easier than having to WORK like the rest of US:-))
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To: doug from upland

eat less food...... is like telling an alcoholic to drink less booze.. its simple for you to say. Not so simple for overweight people to do. Its as much genes as alcoholic is in the genes.


6 posted on 10/27/2021 1:08:02 PM PDT by Ikeon (my bucket list includes punching a guy in the face when he reaches down to pull up his pants😃)
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To: nickcarraway

and big gov hasn’t stepped in to mandate surgeries the deal with this pandemic?


7 posted on 10/27/2021 1:09:56 PM PDT by Bob434
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To: nickcarraway
“Gene therapy”

They’ve lost their friggin minds.

8 posted on 10/27/2021 1:10:15 PM PDT by NativeSon ( )
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To: fruser1
Over 4 Million Deaths per Year Caused by Obesity

This will be mandated as soon as covid wanes.

If it saves only one life!

Not to forget: Obese people can also endanger the lives of others (e.g., if they fall on you and crush you).

So fat people are only being selfish by not submitting to the necessary therapy to rid themselves of the excess lbs (e.g., by means of restructuring their DNA and that of their progeny).

Regards,

9 posted on 10/27/2021 1:13:11 PM PDT by alexander_busek (Extraordinary claims require extraordinary evidence.)
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To: nickcarraway

Let’s tax people based on their BMI!

Or maybe have a BMI mandate where you are ineligible for work, going to restaurants a d healthcare.

Sigh. Love and let live


10 posted on 10/27/2021 1:13:54 PM PDT by laxcoach (The secret to happiness is a bait pen full of pinfish.)
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To: nickcarraway

This is just part of the NWO - vaccine plan to lower the population. I have never seen so many obese kids. It’s scary.


11 posted on 10/27/2021 1:14:50 PM PDT by Maudeen (https://thereishopeinJesus.com - Our ONLY hope! )
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To: nickcarraway

Liquid seed oils (soy, canola, etc), sugar, and refined carbs cause obesity.


12 posted on 10/27/2021 1:16:16 PM PDT by cpt_dave
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To: nickcarraway

Also discussed at length here:

https://freerepublic.com/focus/f-chat/4006902/posts


13 posted on 10/27/2021 1:22:11 PM PDT by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: doug from upland

I tried all that for over a week! Didn’t work!


14 posted on 10/27/2021 1:22:38 PM PDT by Az Joe ("Scratch a Liberal, and a Fascist bleeds")
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To: alexander_busek

And the children.....the CHILDREN!!!!


15 posted on 10/27/2021 1:23:15 PM PDT by Az Joe ("Scratch a Liberal, and a Fascist bleeds")
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To: nickcarraway

Biden should mandate treadmills and dieting


16 posted on 10/27/2021 1:23:23 PM PDT by JerryBlackwell (some animals are more equal than others)
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To: nickcarraway

Non-invasive treatments like “not having that third cheeseburger”.


17 posted on 10/27/2021 1:25:46 PM PDT by coloradan (They're not the mainstream media, they're the gaslight media. It's what they do. )
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To: nickcarraway

It is only necessary to stop stuffing ones face.

And to get up off one’s fat ass and move.

It is that easy and simple.


18 posted on 10/27/2021 1:26:13 PM PDT by Mariner (War criminal #18)
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To: nickcarraway

I still believe Dr. Gott’s no flour, no sugar diet was brilliant. It pretty much sums up every diet that has ever worked.


19 posted on 10/27/2021 1:27:47 PM PDT by viewfromthefrontier
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To: Bob434
"and big gov hasn’t stepped in to mandate surgeries the deal with this pandemic?"

Ain't no surgeries gonna help with this.


20 posted on 10/27/2021 1:28:26 PM PDT by Tell It Right (1st Thessalonians 5:21 -- Put everything to the test, hold fast to that which is true.)
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