Posted on 10/27/2021 12:57:53 PM PDT by nickcarraway
Novel obesity treatments such as modulation of the gut microbiome and gene therapy are underutilized and could help fight the obesity epidemic, according to a new manuscript published in the Endocrine Society’s journal, Endocrine Reviews.
Nearly half of the adults and 20 percent of children in the United States have obesity, yet doctors are under prescribing effective weight loss medications and many patients are not receiving the treatment they need. The weight stigma that exists in healthcare settings makes people with obesity hesitant to seek care until comorbidities develop and reach a dangerous stage. Lack of insurance coverage and cost issues are another factor that creates barriers to obesity treatment.
“Obesity is the epidemic crisis of our time. The disease leads to serious comorbidities such as diabetes, fatty liver disease and cardiovascular disease and significantly shortens a person’s length and quality of life,” said Christos S. Mantzoros, M.D., Sc.D., of Beth Israel Deaconess Medical Center in Boston, Mass. “Until recently we did not understand the genetic and hormonal causes of obesity and how obesity leads to these comorbidities. We have recently started to understand the causes of obesity in humans, which is a big discovery that has led to designing effective therapies.”
In the article, the researchers map out the molecular and hormonal pathways that lead to obesity and the disease’s related comorbidities. This data gives researchers the insights they need to design, test and implement new obesity therapies.
The researchers highlight the need for safer and more effective obesity therapies, including new drug delivery systems, vaccines, modulation of the gut microbiome and gene therapy. Novel medications, including combinations of gastrointestinal hormones and other molecules, are being tested and are expected to lead to significant percentages of weight loss with less side effects once available. As our understanding of obesity improves, more effective medications with fewer side effects will be developed.
Recently approved medications such as semaglutide, a modified gastrointestinal hormone administered once a week, can lead to 15% weight loss when combined with lifestyle changes. Bariatric surgery can lead to up to 40% weight loss, but it is invasive and linked to complications.
“Insurance companies need to pay attention to data from studies and the scientific progress we are making and start covering the medications that are and will be approved soon, given that currently only a small minority of patients with obesity have coverage for the medications and medical care they need,” Mantzoros said. “It would be much more cost effective to cover treatments early instead of waiting for comorbidities and their complications to develop.”
Other authors of the study include: Angeliki Angelidi and Matthew Belanger of Harvard Medical School in Boston, Mass., and Alexander Kokkinos and Chrysi Koliaki of Laiko General Hospital in Athens, Greece. The research received no external funding.
Reference: “Novel Non-invasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy” 26 October 2021, Endocrine Reviews.
Eat less food, eat healthier food, exercise.
This will be mandated as soon as covid wanes.
A line I've heard all my life about things that have turned out later to be wrong
Safe, Non-Invasive Treatments called DIETS and EXERCISE Could Help End Epidemic:-)
eat less food...... is like telling an alcoholic to drink less booze.. its simple for you to say. Not so simple for overweight people to do. Its as much genes as alcoholic is in the genes.
and big gov hasn’t stepped in to mandate surgeries the deal with this pandemic?
They’ve lost their friggin minds.
This will be mandated as soon as covid wanes.
If it saves only one life!
Not to forget: Obese people can also endanger the lives of others (e.g., if they fall on you and crush you).
So fat people are only being selfish by not submitting to the necessary therapy to rid themselves of the excess lbs (e.g., by means of restructuring their DNA and that of their progeny).
Regards,
Let’s tax people based on their BMI!
Or maybe have a BMI mandate where you are ineligible for work, going to restaurants a d healthcare.
Sigh. Love and let live
This is just part of the NWO - vaccine plan to lower the population. I have never seen so many obese kids. It’s scary.
Liquid seed oils (soy, canola, etc), sugar, and refined carbs cause obesity.
I tried all that for over a week! Didn’t work!
And the children.....the CHILDREN!!!!
Biden should mandate treadmills and dieting
Non-invasive treatments like “not having that third cheeseburger”.
It is only necessary to stop stuffing ones face.
And to get up off one’s fat ass and move.
It is that easy and simple.
I still believe Dr. Gott’s no flour, no sugar diet was brilliant. It pretty much sums up every diet that has ever worked.
Ain't no surgeries gonna help with this.
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