My understanding of the mechanism of protection offered by ivermectin is that it interferes with the attachment of the spike protein (SP) to the human cell membrane. The SARS-CoV-2 spike protein is designed to attach to angiotensin-converting enzyme 2 (ACE2) in humans. Ivermectin docks at that same receptor site first and effectively blocks SP attachment, so the SP is left to wander aimlessly through the bloodstream with no place to make a home.
The two main sub-types of immune cells in humans are T cells and macrophages. T cells are designed to recognize particular proteins, such as those from bacteria, in order to activate an immune response. Macrophages destroy foreign cells and are able to pull apart their proteins in order to present them to T cells so the T cells can mount an immune response if necessary. No immune response is necessary for the SP because they’re not alive and cannot replicate until they get inside the cell and use the cell’s own machinery to make copies of itself. As long as it remains outside the cell, thanks to the ivermectin, it’s just blood garbage.
Macrophages see the spike proteins in the blood and know they don’t belong there and pull them apart like rapacious hyenas. The pieces are then carried from the blood as waste. Ivermectin doesn’t destroy anything but simply acts as a sentry to the cell so the T cells and macrophages can do their thing to the invader looking for a home.
I’ve done a lot of study on this subject in the last year, but please be aware that I’m not a physician or a scientist.
Thanks for your thoughts on the Ivermectin and antibodies. I didn’t think it could interfere with those.
My friend is thinking of trying out the horse paste to make sure she can tolerate it so she can make other arrangements if she cannot, but she also wants to get antibody testing done and I didn’t know what technical answer to give to her question.
I sort of also like her thinking on testing out the horse paste and am waiting to find out what she finds out about antibody testing.
Little Linda, post #1580 is the clearest, most concise explanation of how Ivermectin works as well as the process that our immune system does. I can use that to explain this to anyone open to real treatment. Great job.
It may be because you aren’t a doctor or scientist that you can explain this in terms everyone can grasp.
L.L. Thanks for posting this info on Ivermectin!
You may have looked at this at some point?? (May have been posted at sometime by you Ransomnote?)
https://www.drugs.com/ivermectin.html
which links to:
https://www.drugs.com/medical-answers/ivermectin-treat-covid-19-coronavirus-3535912/
(This comment was instructive!)
Snip...”The uncertainty in some of the ivermectin trials for COVID-19 is due to
serious risk of bias
serious risk of imprecision.
There are far fewer randomized controlled trials (RCT) for ivermectin compared to other COVID treatments. The RCT included multiple small trials, that had fewer patients enrolled and had fewer events recorded.”
One study: (Snip....)
“ICON Clinical Study Results
(Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019: The Ivermectin in COVID Nineteen Study)
The ICON study, which was a multihospital retrospective cohort study, involved 280 patients, 173 patients were treated with at least one oral dose of 200 μg/kg ivermectin and 107 patients had no ivermectin treatment. Patients could also be treated with hydroxychloroquine, azithromycin, or both.
The results from this study showed that:
Overall mortality was significantly lower for the ivermectin group (15%) compared to the usual treatment group (25.2%) using figures from the unmatched cohort.
Mortality for the subgroup of patients who had severe pulmonary involvement was lower in the ivermectin treatment group (38.8%) compared to the usual treatment group (80.7%) from the unmatched cohort.
There was no significant difference between the two treatment groups regarding successful extubation rates of mechanically ventilated patients. Successful extubation is when the patient has had the breathing tube that has been used for mechanical ventilation removed and they can successfully breath on their own.
Length of hospital stay was not significantly different between the ivermectin treatment group and the regular treatment group....Snip”
2nd study (snip...)
“IVERCOR-COVID-19 trial
Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial
The IVERCOR-COVID-19 trial was a randomized, double-blind, placebo controlled trial involving 501 patients. The aim of this trial was to determine whether ivermectin treatment could prevent hospitalization of individuals with early COVID-19. One group was treated with ivermectin plus standard treatment and the other group was treated with placebo with standard treatment. Patients were not allowed to take hydroxychloroquine, chloroquine or antiviral drugs.
The results of this trial were published on 2 July 2021 showed that:
The percentage of patients that needed hospitalization was 5.6% in the ivermectin treatment group and 8.4% in the placebo group, but the difference between the two groups was not statistically significantly
There was no statistically significant difference in median time from patient enrollment to hospitalization between the treatment groups. The ivermectin treatment group median time to hospitalization was 3.5 days and placebo group 3 days.
There was no statistically significant difference in mean time from study enrolment until a patient was put on invasive mechanical ventilatory support (MVS). The ivermectin treatment group was 5.25 days compared to the placebo group which was 10 days.
The limitations in this study was noted as a:
low percentage of hospitalized patients
The mean dose of ivermectin was 192.37 μg/kg/day which was below the dose proposed as probably being effective.”
NOTE THE LAST LINE. “BELOW THE DOSE PROPOSED AS PROBABLY BEING EFFECTIVE”! Also note “Patients were not allowed to take hydroxychloroquine, chloroquine or antiviral drugs.”
Excellent explanation. ThanQ