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What is a 'randomized controlled trial', and why are the positive results of Hydroxychloroquine for Covid-19 greeted with skepticism?
Washington Examiner via MSN ^ | 09/18/2020 | David Hogberg

Posted on 09/18/2020 8:55:16 AM PDT by SeekAndFind

Once an obscure and highly technical term, it first entered common parlance when, in mid-March, President Trump suggested hydroxychloroquine as a possible treatment for COVID-19. Physicians and scientists said that randomized controlled trials involving the drug would be needed before we could know whether it was an effective treatment.

More recently, media coverage of a possible coronavirus vaccine has often mentioned the term, noting that vaccines must go through such trials before the Food and Drug Administration will approve them.

Indeed, it has become prominent in the news since the pandemic began. Typing the term into the search engine Google and selecting "News" will yield more than 146,000 results. A search of the Washington Examiner finds 20 articles using the term since March. We often write that it is "considered the gold standard in medical research."

But what, exactly, is a randomized controlled trial?

In summary, it is a scientific experiment in which patients are randomly assigned to receive either a specific treatment or a placebo. Sometimes, patients are assigned to a third group that receives the best available treatment that has been tested by previous research. That way, the new treatment can be compared to the most effective established treatment.

Ultimately, it will inform researchers about the efficacy and safety of a specific treatment. Researchers will be able to determine whether the treatment is more effective than no treatment or the best established treatment. They will also be able to better understand what side effects the treatment may have.

Assigning patients randomly enables researchers to eliminate certain sources of bias that could otherwise confound the results.

(Excerpt) Read more at msn.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: clinicaltrials; covid19; hcq; hcqtrial; hydroxychloroquine; randomtrial
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Compare randomized controlled trials to another very common type of study known as a "retrospective study." A retrospective study enables researchers to examine events that have happened in the past. For example, take a recent retrospective study that compared patients who were hospitalized with COVID-19 and treated with hydroxychloroquine to patients who were not treated with it.

The study found a lower mortality rate among those patients who took hydroxychloroquine. But these types of studies have a number of limitations, the most important being bias. Specifically, physicians might be prescribing hydroxychloroquine for those patients most likely to do well with the drug and not prescribing it for those they believe it will not help. That alone may explain why the study found that patients taking hydroxychloroquine did better.

1 posted on 09/18/2020 8:55:16 AM PDT by SeekAndFind
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To: Mrs. Don-o; tellw; Huskrrrr; Jane Long; Freedom'sWorthIt; Freedom56v2; BDParrish; Phx_RC

Ping as per your request


2 posted on 09/18/2020 8:55:53 AM PDT by SeekAndFind
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To: SeekAndFind

Because. Trump.....................


3 posted on 09/18/2020 8:58:39 AM PDT by Red Badger (Sine Q-Anon.....................very............)
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To: SeekAndFind

It is amazing the people who don’t understand this, and the nature of double blind experiments, who still think they are qualified to have an opinion.


4 posted on 09/18/2020 9:07:51 AM PDT by RedStateRocker (Nuke Mecca. Deport all illegals. Abolish the DEA, IRS and ATF,.)
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To: SeekAndFind

Where are the randomized controlled trials showing the efficacy of cloth or paper masks? The only peer reviewed studies I’ve seen say they are ineffective.


5 posted on 09/18/2020 9:12:19 AM PDT by circlecity
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To: SeekAndFind

So ... where’s the randomized controlled trials for mask-wearing and ‘social distancing’?


6 posted on 09/18/2020 9:15:21 AM PDT by bassmaner (Hey commies: I'm a white male, and guilty of NOTHING! Sell your 'white g uilt' elschewhereive)
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To: circlecity

GMTA ... :-)


7 posted on 09/18/2020 9:16:09 AM PDT by bassmaner (Hey commies: I'm a white male, and guilty of NOTHING! Sell your 'white g uilt' elschewhereive)
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To: RedStateRocker; SeekAndFind

Agree....especially people like FRAUDci.

He always calls for double blind studies, but I’ve YET to see HIS links to HIS, or anyone’s, studies when he flip-flops on his China Flu edicts.


8 posted on 09/18/2020 9:16:47 AM PDT by Jane Long (Praise God, from whom ALL blessings flow.)
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To: circlecity; SeekAndFind

Also....the Govs keeping their state’s establishments on perpetual lock down always mention “science” and “metrics”.....

My question....

What do the metrics have to be, for 100% OPENING UP??

They NEVER tell you THAT.


9 posted on 09/18/2020 9:18:18 AM PDT by Jane Long (Praise God, from whom ALL blessings flow.)
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To: SeekAndFind

When did they hold the randomized, controlled trial on whether or not masks are effective against the virus?

What, they didn’t??


10 posted on 09/18/2020 9:19:38 AM PDT by Buckeye McFrog (Patrick Henry would have been an anti-vaxxer.)
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To: RedStateRocker
It is amazing the people who don’t understand this, and the nature of double blind experiments, who still think they are qualified to have an opinion.

Every prediction by so called experts has been wrong YOU moron.

11 posted on 09/18/2020 9:26:28 AM PDT by va22030
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To: SeekAndFind

A Dr who is reporting astounding field success with ivermectin treatment points out that RCT would actually be unethical, to withhold treatment with a high rate of success and potentially let untreated patients die....in the name of science. Ditto with HCQ.

Fauci the bureaucratic scientist who treats no patients....has no such moral qualms.


12 posted on 09/18/2020 9:33:43 AM PDT by silverleaf (A live Biden speech is like a solar eclipse: rare, and leaves everyone in the dark)
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To: va22030

You are the perfect example of someone who is too ignorant to have an opinion on anything. Being called a ‘moron; by an uneducated, inbred retard such as yourself is a compliment to anyone not married to a close relative.


13 posted on 09/18/2020 9:45:04 AM PDT by RedStateRocker (Nuke Mecca. Deport all illegals. Abolish the DEA, IRS and ATF,.)
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To: silverleaf

RE: A Dr who is reporting astounding field success with ivermectin treatment points out that RCT would actually be unethical, to withhold treatment with a high rate of success and potentially let untreated patients die....in the name of science. Ditto with HCQ.

_____________________________________________

That doctor’s name is Thomas Borody, a world renowned medical doctor from Australia with over 40 years experience in clinical research and practice, including at the St Vincent Hospital in Sydney and at the Mayo clinic in the US.

Some of his most ground breaking contributions in medical science include the development of a tritherapy for peptic ulcers, the development of faecal microbiota transplants for colitis and other diseases, and recently, a therapy for Crohn disease.

In 1984 he established the Centre for Digestive Diseases in Sydney. He oversaw its growth into an active clinical research institute with 65 employees.

Professor Borody has published numerous articles and is a reviewer for leading international medical journals.

His interview can be watched here:

http://covexit.com/professor-thomas-borody-interview-part-1/

Interestingly, his opinion on RCT is also shared by Dr. Didier Raoult, director of the Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes. He gained significant worldwide attention during the COVID-19 pandemic for promoting Hydroxychloroquine as a treatment for the disease.


14 posted on 09/18/2020 9:45:39 AM PDT by SeekAndFind
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To: SeekAndFind; All

Back room fighting over juicy government contracts, aka, chasing the money?


15 posted on 09/18/2020 9:46:38 AM PDT by Amendment10
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To: RedStateRocker

Amen to that statement


16 posted on 09/18/2020 9:49:17 AM PDT by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: SeekAndFind; Liz; bitt; LucyT; LS; Travis McGee; bagster; Jim Robinson; All

https://en.wikipedia.org/wiki/Sildenafil

How EVIL & BIG is BIG PHARMA? WHO and WHAT can THEY BUY?

https://www.youtube.com/watch?v=oMeulTWdqiY

PFIZER...Bob 1st person speaking Dole. Landmark SC case Kelo vs Connecticut.

https://en.wikipedia.org/wiki/Kelo_v._City_of_New_London

How is it that Pfizer spinoff...animal vaccine maker Zoetis recently opened up another lab in CHYna?

Hearings? Crickets. Alt-media (right or left)? Crickets. ANY MEDIA OR INTERNET? F’n CRICKETS. FYI patriots.

https://www.youtube.com/watch?v=K8E_zMLCRNg

Politicians for sale. Robes for sale. Citizens for sale.

Blue pill? Red pill? No matter...take BIG PHARMA pill. DON’T READ the side effects. That’s their “plausible deniability”.


17 posted on 09/18/2020 9:57:04 AM PDT by PGalt (Past Peak Civilization?)
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To: Jane Long

Fauci: “Only the most carefully managed, double-blind, Big Pharma-funded study can be allowed to overturn any of my whims.” ;)


18 posted on 09/18/2020 9:57:43 AM PDT by Mr. Jeeves ([CTRL]-[GALT]-[DELETE])
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To: circlecity

Just out of curiosity who would you perform a randomized and blinded study wherein people wear a mask — by definition you can see who is in what group which would lead to bias.

As others have pointed out, this is a technical term that few people understand.


19 posted on 09/18/2020 10:01:02 AM PDT by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: Buckeye McFrog

It would be kind of hard to hold a doubly blinded RCT on mask wearing — for obvious reason. You can see who is in what group.


20 posted on 09/18/2020 10:01:55 AM PDT by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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