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Ergothioneine – a diet-derived antioxidant with therapeutic potential
FEBS LettersVolume 592, Issue 20 ^ | 31 May 2018 | Barry Halliwell, Irwin K. Cheah, Richard M. Y. Tang

Posted on 06/07/2020 7:31:30 PM PDT by ConservativeMind

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This is a large excerpt. Ergothioneine is used by mitochondria through a special ionic pathway conserved in nearly all of our cells. Unfortunately, mushrooms are the most common way we get it and we can’t make it ourselves. For that matter, only some mushrooms can “make” it—the rest suck up what is in the growing substrate, which would normally be decaying trees, rather than straw.

There is a table showing Porcini mushrooms as the highest in ET, with King Oyster and others falling behind quite a bit, but still better than eating 2.2 pounds of garlic!

Our bodies additionally have a way to regenerate the ET molecule for as long as a month.

This must be an important nutritional component when these built-in mechanisms only work for the ET molecule. Perhaps this is a reason for the disparity among many with health-related conditions.

1 posted on 06/07/2020 7:31:30 PM PDT by ConservativeMind
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To: ConservativeMind

Huh?


2 posted on 06/07/2020 7:35:10 PM PDT by old-ager (anti-new-ager)
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To: Fungi

Ping


3 posted on 06/07/2020 7:41:51 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

So mushrooms on pizza and with steak is good as long was we don’t go the way of Clint Eastwood in the movie The Beguilde?


4 posted on 06/07/2020 7:45:15 PM PDT by Deaf Smith (When a Texan takes his chances, chances will be taken that's for sure)
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To: ConservativeMind

When I was about 14 or 15 we had a friend who was an old Swiss Italian that came to Thanksgiving dinner. We lived up on a hill and he was afraid to drive up there so I walked down to the bottom and drove his pickup up to the house. On the way he started hollering stop, stop. I thought I did something to his pickup. He was hard to understand but he kept saying boleta, boleta. He got out and picked this huge mushroom. That is one of the few mushrooms I can identify.


5 posted on 06/07/2020 8:04:56 PM PDT by Lurkina.n.Learnin (The Revolution Will Not Be Televised but It Will Be Livestreamed)
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To: ConservativeMind; little jeremiah

Bttt

FYI


6 posted on 06/07/2020 8:09:33 PM PDT by thinden
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To: ConservativeMind; little jeremiah; BenLurkin

Thanks!

More Shitaki and a side of Tempeh! (Porcini is a bit pricey around here!)

Does it reside in the wall of the Mitochondria, or the Matrix?

The nifty thing is that looks like it does not excrete and prompts our body to conserve it once we take it in.


7 posted on 06/07/2020 8:36:45 PM PDT by Pete from Shawnee Mission
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To: ConservativeMind

BKMRK for later.


8 posted on 06/07/2020 11:39:14 PM PDT by matthew fuller (Sick and tired of the WuHu Flu Blues.)
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To: ConservativeMind

where do you buy your Boletus edulis (cepes)


9 posted on 09/20/2020 2:18:44 PM PDT by ckilmer
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To: ConservativeMind

Porcini is the best tasting mushroom evah! But you can only find dried. Would it still contain the ingredient?

Also, please note: when they say it is is cow’s milk, probably only in raw. Which is so much better anyway.


10 posted on 09/20/2020 2:23:07 PM PDT by Yaelle
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To: ckilmer

It will be found dried in large supermarkets or Whole Foods. It will probably be called porcini. Probably found hanging with other dried mushrooms and herbs in the produce area.


11 posted on 09/20/2020 2:28:37 PM PDT by Yaelle
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To: ckilmer; Yaelle

What Yaelle said is how we get it, and, yes, it’s called “Porcini.” It is dried and packaged at Whole Foods and other stores. We’ve seen and gotten it at a place called “Central Market” when visiting in Texas. Sprouts may have it. Amazon surely does. At stores, it does occasionally go on sale, because it was on sale when we bought it a Central Market. I haven’t seen it on sale at Whole Foods, yet.

We keep trying to find it fresh, but haven’t, yet.

Now, what got two FReepers today to stumble across a thread I posted months ago? :-)


12 posted on 09/20/2020 4:02:18 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

you set up a second post on the matter. from that I saved a couple of links including this one that you sent me.
https://www.freerepublic.com/focus/f-chat/3853199/posts

That’s where I noticed that Boletus edulis (cepes) has the highest amount of Ergothioneine

Now I’m just getting around to acting on the information.
Two details:
1.)
the list you provided does not include porcini mushrooms by name. Is Boletus edulis (cepes) a kind of porcini mushroom?
2.)have you noticed any beneficial effect?


13 posted on 09/20/2020 6:15:21 PM PDT by ckilmer
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To: ckilmer
We have taken to having multiple types of mushrooms each week. This past week we’ve eaten shiitake, king oyster, and baby bella. Our diet has had mushrooms weekly for going on two years now.

At first, we felt a bit more energetic and slightly more clear-minded. Together these probably translate into “positivity.” Our health seemed slightly improved.

It feels like we’ve maintained or only gotten better, since, but I can’t point to only mushrooms for that. We try a lot of supplements and continually tweak from new information.

Honestly, I encourage everyone to eat whatever mushrooms they can afford, and preferably those with the better ergo numbers for the money.

It’s hard to keep any antioxidant in mitochondria for any length of time. This is the only one that stays a while. This is the most unique benefit of mushrooms.

Do understand mushrooms are also a rather unique source for glutathione, another key cellular antioxidant.

https://www.sciencedaily.com/releases/2017/11/171109100409.htm

For the small number of calories, as well, mushrooms are a wonderful buy.

14 posted on 09/20/2020 9:29:50 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I daily drink a chaga lions mane tea. sometimes I’ll throw in reisi. A couple times a week I’ll eat white button, baby bella or shiitake mushrooms. I take supplements that include maitake, cordyceps and turkey tail.

I think the regime improves my spirits.

this is the first I’ve heard of porcini.

I’m always intrigued and interested in your health related posts.

did you stick with the fisetin routine?


15 posted on 09/21/2020 12:08:45 PM PDT by ckilmer
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To: ckilmer
Actually, I did an entire bottle in three days, but now expect to do that every other month or two. Instead, I’ve been focusing on iodine’s possible impacts on prostate, breast and other inflamed or cancerous cells.

Lugol’s is not the best approach, nor Iodoral. Strangely, the elemental iodine, as in kelp, is the form least likely to cause thyroid issues. Forms with potassium center their absorption in the thyroid and appear to be the primary trigger for thyroid autoimmunity issues. To prevent those, having fortified with selenium and daily zinc and antioxidants will both prevent reactions and tamp them down if you are already showing autoimmune thyroid antibodies.

The safest form of kelp appears to be Swanson’s Kelp (elemental iodine/fewest contaminants/best price fromConsumerLab.com), which is a kelp extract (save for a little powder they throw in). The upper tolerable dose is 1,100 micrograms a day, but I’ve incremented myself beyond that to closer to 3,000 micrograms a day using those kelp tablets and about 1,500 micrograms equivalent from Iodoral.

All sorts of research out there, but I don’t normally encourage people to do stuff beyond where it is safe, although I’ve done some stuff with multiple grams of grape seed extract with positive outcomes.

16 posted on 09/21/2020 1:04:53 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Cogito_ergo_thioneine?


17 posted on 09/21/2020 1:07:35 PM PDT by aposiopetic
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To: ckilmer

I would suggest to ingest the mushrooms rather than leave anything behind.

I am not aware of ergo being leeched out of mushrooms, for instance. We have powdered forms of the mushrooms you mention, but we blend them into a glass of low sodium V-8 juice.


18 posted on 09/21/2020 1:12:17 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

is it your opinion that iodine/kelp will shrink the prostate when used at the high doses you suggest?


19 posted on 09/22/2020 10:13:52 AM PDT by ckilmer
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To: ckilmer
Yes, it is apparently able to help prostate cells enter into apoptosis due to special iodine receptors that don’t appear to normally get enough free iodine to do their work.

It seems the sheer density and design of prostate cells renders a number of potentially beneficial substances incapable of getting in there to help.

20 posted on 09/22/2020 10:34:00 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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