Posted on 04/05/2020 9:59:01 AM PDT by Mariner
Yesterday's thread here:
http://freerepublic.com/focus/chat/3831710/posts?page=1
Very important. Hope they can do it fast.
some ass really going after Trump right now for promoting his miracle drug
it was CNN going after him about the drug
F’n ass wants HQC to fail, Wants a Trump to shut up. Haha CNN
to get the drug drs may require you to test positive...so that is another big problem.
you cant get tested right now
they need to work on both of these problems..Abbott labs test has to get out there for sure
CNN sure doesnt want this drug to work. I want to know if Chris Cuomo is on it.
He is about to hit the critical time frame of when things can go south.
If a drug shows promising results and I had a condition where Coronavirus was a danger to my life, I would want that drug. Before I get ventilated.
That is better then no hope. A lot of folks in Italy had no hope.
Deaths: for some reason worldometers has the 24 hour NY state update 594 which is has been that way all day US total 1154
BNO has 245 NY state US total 724
NYC city numbers are 2 hours late
in other words Worldometers is counting the NYC info from last evening (again) in todays numbers (first time they have done that)
and BNO has no NYC data for todays number since they are still waiting for the update...(will it come?)
Long; not verified; from another site; but potentially seismic.
= = = = = = = = = = = = = = = = = = = = =
libertymavenstock
libertymavenstock
Follow
Apr 4 · 8 min read
In the last 3–5 days, a mountain of anecdotal evidence has come out
of NYC, Italy, Spain, etc. about COVID-19 and characteristics of
patients who get seriously ill. It’s not only piling up but now leading
to a general field-level consensus backed up by a few previously
little-known studies that we’ve had it all wrong the whole time. Well, a
few had some things eerily correct (cough Trump cough), especially with
Hydroxychloroquine with Azithromicin, but we’ll get to that in a
minute.
There is no ‘pneumonia’ nor ARDS. At least not the ARDS with established
treatment protocols and procedures we’re familiar with. Ventilators are
not only the wrong solution, but high pressure intubation can actually
wind up causing more damage than without, not to mention complications
from tracheal scarring and ulcers given the duration of intubation often
required… They may still have a use in the immediate future for
patients too far to bring back with this newfound knowledge, but moving
forward a new treatment protocol needs to be established so we stop
treating patients for the wrong disease.
The past 48 hours or so have seen a huge revelation: COVID-19 causes
prolonged and progressive hypoxia (starving your body of oxygen) by
binding to the heme groups in hemoglobin in your red blood cells. People
are simply desaturating (losing o2 in their blood), and that’s what
eventually leads to organ failures that kill them, not any form of ARDS
or pneumonia. All the damage to the lungs you see in CT scans are from
the release of oxidative iron from the hemes, this overwhelms the
natural defenses against pulmonary oxidative stress and causes that
nice, always-bilateral ground glass opacity in the lungs. Patients
returning for re-hospitalization days or weeks after recovery suffering
from apparent delayed post-hypoxic leukoencephalopathy strengthen the
notion COVID-19 patients are suffering from hypoxia despite no signs ofrespiratory ‘tire out’ or fatigue.
Here’s the breakdown of the whole process, including some ELI5-level cliff notes. Much has been simplified just to keep it digestible and layman-friendly.
Your red blood cells carry oxygen from your lungs to all your organs and
the rest of your body. Red blood cells can do this thanks to
hemoglobin, which is a protein consisting of four “hemes”. Hemes have a
special kind of iron ion, which is normally quite toxic in its free
form, locked away in its center with a porphyrin acting as it’s
‘container’. In this way, the iron ion can be ‘caged’ and carried around
safely by the hemoglobin, but used to bind to oxygen when it gets to
your lungs.
When the red blood cell gets to the alveoli, or the little sacs in your
lungs where all the gas exchange happens, that special little iron ion
can flip between FE2+ and FE3+ states with electron exchange and bond to
some oxygen, then it goes off on its little merry way to deliver o2
elsewhere.
Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and
in doing so that special and toxic oxidative iron ion is “disassociated”
(released). It’s basically let out of the cage and now freely roaming
around on its own. This is bad for two reasons:
1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once
all the hemoglobin is impaired, the red blood cell is essentially turned
into a Freightliner truck cab with no trailer and no ability to store
its cargo.. it is useless and just running around with COVID-19 virus
attached to its porphyrin. All these useless trucks running around not
delivering oxygen is what starts to lead to desaturation, or watching
the patient’s spo2 levels drop. It is INCORRECT to assume traditional
ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a
lot like carbon monoxide poisoning, in which CO is bound to the
hemoglobin, making it unable to carry oxygen. In those cases,
ventilators aren’t treating the root cause; the patient’s lungs aren’t
‘tiring out’, they’re pumping just fine. The red blood cells just can’t
carry o2, end of story. Only in this case, unlike CO poisoning in which
eventually the CO can break off, the affected hemoglobin is permanently
stripped of its ability to carry o2 because it has lost its iron ion.
The body compensates for this lack of o2 carrying capacity and
deliveries by having your kidneys release hormones like erythropoietin,
which tell your bone marrow factories to ramp up production on new red
blood cells with freshly made and fully functioning hemoglobin. This is
the reason you find elevated hemoglobin and decreased blood oxygen
saturation as one of the 3 primary indicators of whether the shit is
about to hit the fan for a particular patient or not.
2) That little iron ion, along with millions of its friends released
from other hemes, are now floating through your blood freely. As I
mentioned before, this type of iron ion is highly reactive and causes
oxidative damage. It turns out that this happens to a limited extent
naturally in our bodies and we have cleanup & defense mechanisms to
keep the balance. The lungs, in particular, have 3 primary defenses to
maintain “iron homeostasis”, 2 of which are in the alveoli, those little
sacs in your lungs we talked about earlier. The first of the two are
little macrophages that roam around and scavenge up any free radicals
like this oxidative iron. The second is a lining on the walls (called
the epithelial surface) which has a thin layer of fluid packed with high
levels of antioxidant molecules.. things like abscorbic acid (AKA
Vitamin C) among others. Well, this is usually good enough for naturally
occurring rogue iron ions but with COVID-19 running rampant your body
is now basically like a progressive state letting out all the prisoners
out of the prisons… it’s just too much iron and it begins to overwhelm
your lungs’ countermeasures, and thus begins the process of pulmonary
oxidative stress. This leads to damage and inflammation, which leads to
all that nasty stuff and damage you see in CT scans of COVID-19 patient
lungs. Ever noticed how it’s always bilateral? (both lungs at the same
time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE.
TIME.
— — — — — — — — — — — — –
Once your body is now running out of control, with all your oxygen
trucks running around without any freight, and tons of this toxic form
of iron floating around in your bloodstream, other defenses kick in.
While your lungs are busy with all this oxidative stress they can’t
handle, and your organs are being starved of o2 without their constant
stream of deliveries from red blood cell’s hemoglobin, and your liver is
attempting to do its best to remove the iron and store it in its ‘iron
vault’. Only its getting overwhelmed too. It’s starved for oxygen and
fighting a losing battle from all your hemoglobin letting its iron free,
and starts crying out “help, I’m taking damage!” by releasing an enzyme
called alanine aminotransferase (ALT). BOOM, there is your second of 3
primary indicators of whether the shit is about to hit the fan for a
particular patient or not.
Eventually, if the patient’s immune system doesn’t fight off the virus
in time before their blood oxygen saturation drops too low, ventilator
or no ventilator, organs start shutting down. No fuel, no work. The only
way to even try to keep them going is max oxygen, even a hyperbaric
chamber if one is available on 100% oxygen at multiple atmospheres of
pressure, just to give what’s left of their functioning hemoglobin a
chance to carry enough o2 to the organs and keep them alive. Yeah we
don’t have nearly enough of those chambers, so some fresh red blood
cells with normal hemoglobin in the form of a transfusion will have to
do.
The core point being, treating patients with the iron ions stripped from
their hemoglobin (rendering it abnormally nonfunctional) with
ventilator intubation is futile, unless you’re just hoping the patient’s
immune system will work its magic in time. The root of the illness
needs to be addressed.
Best case scenario? Treatment regimen early, before symptoms progress
too far. Hydroxychloroquine (more on that in a minute, I promise) with
Azithromicin has shown fantastic, albeit critics keep mentioning
‘anecdotal’ to describe the mountain, promise and I’ll explain why it
does so well next. But forget straight-up plasma with antibodies, that
might work early but if the patient is too far gone they’ll need more.
They’ll need all the blood: antibodies and red blood cells. No help in
sending over a detachment of ammunition to a soldier already unconscious
and bleeding out on the battlefield, you need to send that ammo along
with some hemoglobin-stimulant-magic so that he can wake up and fire
those shots at the enemy.
The story with Hydroxychloroquine
All that hilariously misguided and counterproductive criticism the media
piled on chloroquine (purely for political reasons) as a viable
treatment will now go down as the biggest Fake News blunder to rule them
all. The media actively engaged their activism to fight ‘bad orange
man’ at the cost of thousands of lives. Shame on them.
How does chloroquine work? Same way as it does for malaria. You see,
malaria is this little parasite that enters the red blood cells and
starts eating hemoglobin as its food source. The reason chloroquine
works for malaria is the same reason it works for COVID-19 — while not
fully understood, it is suspected to bind to DNA and interfere with the
ability to work magic on hemoglobin. The same mechanism that stops
malaria from getting its hands on hemoglobin and gobbling it up seems to
do the same to COVID-19 (essentially little snippets of DNA in an
envelope) from binding to it. On top of that, Hydroxychloroquine (an
advanced descendant of regular old chloroquine) lowers the pH which can
interfere with the replication of the virus. Again, while the full
details are not known, the entire premise of this potentially ‘game
changing’ treatment is to prevent hemoglobin from being interfered with,
whether due to malaria or COVID-19.
No longer can the media and armchair pseudo-physicians sit in their
little ivory towers, proclaiming “DUR so stoopid, malaria is bacteria,
COVID-19 is virus, anti-bacteria drug no work on virus!”. They never got
the memo that a drug doesn’t need to directly act on the pathogen to be
effective. Sometimes it’s enough just to stop it from doing what it
does to hemoglobin, regardless of the means it uses to do so.
Anyway, enough of the rant. What’s the end result here? First, the
ventilator emergency needs to be re-examined. If you’re putting a
patient on a ventilator because they’re going into a coma and need
mechanical breathing to stay alive, okay we get it. Give ’em time for
their immune systems to pull through. But if they’re conscious, alert,
compliant — keep them on O2. Max it if you have to. If you HAVE to
inevitably ventilate, do it at low pressure but max O2. Don’t tear up
their lungs with max PEEP, you’re doing more harm to the patient because
you’re treating the wrong disease.
Ideally, some form of treatment needs to happen to:
Inhibit viral growth and replication. Here plays CHQ+ZPAK+ZINC or other
retroviral therapies being studies. Less virus, less hemoglobin losing
its iron, less severity and damage.
Therapies used for anyone with abnormal hemoglobin or malfunctioning red
blood cells. Blood transfusions. Whatever, I don’t know the full
breadth and scope because I’m not a physician. But think along those
lines, and treat the real disease. If you’re thinking about giving them
plasma with antibodies, maybe if they’re already in bad shape think
again and give them BLOOD with antibodies, or at least blood followed by
plasma with antibodies.
bkmk
THIS is the mortality issue with black people. Other peoples too...
People that are heterozygous for sickle cell are doomed when they get this!
We need a link for reference. What site did it come from?
Until then I consider it Tinfoil hat material.
I still see nothing about those that have red blood disorders that are thought to have evolved in nature due to malaria...such as sickle cell and thalessemia
I can’t figure out if those people are more at risk or less at risk.
They already have oxygen level problems in their blood cells. Seems to me that would make them more at risk
Totally agree. “The dog did not bark in the night.”
I feel this would be the same for thalessemia which may be one of the many reasons why Iran and Italy had such a problem...
Iran also has an issue with sickle cell
It won't be safe to reopen the schools until CV19 can be successfully and reliably treated on an out-patient basis, i.e., without requiring hospital admission.
pence just said each state is getting machines and then sending out the tests
not sure where they are going. sounds like you will still have to go to hospital
Thank you very much for your No. 170.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.