Posted on 03/11/2020 8:06:12 AM PDT by Vermont Lt
Time to stay calm and continue on....
Yesterday's thread is here:
http://www.freerepublic.com/focus/f-chat/3823193/posts
We’re oldsters....we are quarantining ourselves
El Salvador and others:
Latin American countries stepped up measures to slow the advance of the coronavirus Wednesday, announcing a slew of restrictions on travelers from the worst-affected countries and shutting down major sports events.
Argentina, Colombia and Peru announced that travelers from China, Italy, Spain and France would be isolated on arrival.
El Salvador went further, with President Nayib Bukele announcing late Wednesday the Central American country would ban entry to all foreigners for a period of 21 days.
The move would affect “any foreigner who is not a resident or diplomat” posted in the country, Bukele said, adding that Salvadorans arriving from countries hit by the virus would face a 30-day quarantine.
https://news.yahoo.com/latin-america-steps-measures-against-coronavirus-spread-214445126.html
Biotechnology company Moderna Inc, which is working with the U.S.-funded National Institutes of Health (NIH), is the closest to human testing, announcing plans to start a trial with 45 people in Seattle this month.
Testing for the specific risk of vaccine enhancement in animals will proceed simultaneously with human trials, the NIH told Reuters, which it said should establish whether it is safe to expose larger numbers of people to the vaccine. Moderna did not respond to requests for comment.
As of Monday, all but six of Osaka’s 55 infections have been linked to one or several of four small “live houses” in Osaka city.
That is how they may just stay at zero if they are lucky.
The decision includes the European Union, Switzerland, India, Pakistan, Sri Lanka, Philippines, Sudan, Ethiopia, South Sudan, Eritrea, Kenya, Djibouti, and Somalia, source added, saying the Kingdom also suspended entry to those coming from these countries.
Saudi Arabia also suspended passenger traffic through all land crossings with Jordan
excludes health care workers and humanitarian aid. Saudi has 45 cases.
The U.S. State Department has decided to suspend non-essential travel by staff because of the spread of the coronavirus and will only permit mission-critical trips, three sources familiar with the matter said on Wednesday.
Meghan Markle, the Duchess of Sussex, has flown back to Canada without husband Prince Harry...
https://www.mirror.co.uk/news/uk-news/meghan-markles-tears-bittersweet-goodbye-21675791
What is this? Has Harry been told to stay in England and sequester with the rest of the RF ?
Shutting down after a long day.
yes, those are plastic bags on their little chicom heads, as they retreat to Beijing
Tracy Grimshaw is pulled from A Current Affair because Tom Hanks’ wife used her dressing room before coronavirus diagnosis - as Karl Stefanovic steps in to replace her
From supermarkets to nightclubs and even a hair salon: Horrifying map shows Australia’s coronavirus hotspots as patients continue to ignore self-isolation rules
Australians struck down by coronavirus are ignoring the advice of health authorities by going to work
take care, Mariner
a note from the Philippines.
President Duterte is being tested, and the Senate is closed. Several cases in a Manila suburb (Marikina). Schools in Manila are closed for now.
The big Agricultural trade fair has been postponed (we sell organic rice and were supposed to set up a kiosk and now we will stay home).
Our area in the provinces is still okay, but since many folks have relatives working in Manila and coming home on weekends, it’s just a matter of time.
While South Korea’s actual mortality rate, (deaths/resolved cases) has fallen to 15.3%, the vaunted 0.7% death rate calculated using deaths/total cases is creeping up, and is now 0.84%. With fewer new cases to pad the numbers and more cases “resolving”, will this trend continue? Maybe Dr. Fauci’s 1% estimate is very close.
At the risk of repeating myself, it’s a “dangerous opportunity.”
So grateful I live in a largely capitalist country. Consider the poor Chinese unable to do any shifting for themselves or innovating or reacting, I guess just waiting for permission to go to the factory again.
Once they unweld the door
Sophisticated modelling of the outbreak suggests that China had 114,325 cases by the end of February 2020, a figure that would have been 67 times higher without interventions such as early detection, isolation of the infected, and travel restrictions.
But if the interventions could have been brought in a week earlier, 66% fewer people would have been infected, the analysis found. The same measures brought in three weeks earlier could have reduced cases by 95%.
https://www.medrxiv.org/content/10.1101/2020.03.03.20029843v2
25 discharged patients with COVID-19 infection were back hospitalized because of the virus mRNA recurrence. The median age of these 17 females and 8 males was 28 years (16.25~42), including 6 children under 12 years old.
21 of them had no comorbidity and 22 patients had the history of residing in Hubei province. Besides, 24 of them were once non-severe patient with the common symptoms of fever (17/25) and cough (14/25) at onset. Overall, with 14 (13-18.5) days of the hospital stay, as well as 13 (10.5-16.5) days of antivirus treatment, the patients all discharged in 2 (1-3.8) days after two consecutive negative results on virus mRNA RT-PCR detection, as well as improvements on chest computed tomography (CT) evidence.
With 14/25 of cloacal swab samples and rest of Nasal Swabs or oropharynx swab samples testing, these patients presented the repeated positive COVID-19 mRNA within 3 (2-7) days after the hospital. Notably, the median time from their last negative result to turning positive was 6 (4-10) days.
These patients were then hospitalized again and continued the quarantine protocol. All these patients were asymptomatic and chest CT scanning indicated that 12 of them even showed improvement while rest of them represented with no obvious change compared with previous images. With a few days of prophylactic intervention with Chinese herbal medicine, the RT-PCR results of virus mRNA detection were all turning to negative in both nasopharyngeal swab and cloacal swab samples.
Furthermore, correlation analysis indicated that there was a significant inverse correlation existed between serum D Dimer level and the duration of antiviral treatment (r=-0.637, p=0.002), while lymphocyte concentration significantly positively correlated (r=0.52, p=0.008) with the duration of virus reversal. These implied that the imperfect antivirus therapy probably was responsible for the recurrence of COVID-19 virus.
NOT PEER REVIEWED:
https://www.medrxiv.org/content/10.1101/2020.03.06.20031377v1.full.pdf
It has been reported that SARS-CoV directly infects monocytes, macrophages and T lymphocytes in human.17 The PLD may also be secondary to activation of T lymphocytes.18
Our findings showed that CD4 and CD8 T lymphocytes have significant difference (p < 0.01) between mild (Non-ICU) and severe or critical (ICU) cases without glucocorticoid treatment indicating COVID-19 directly effected on immune system is possible.
COVID-19 has spread rapidly since it was first identified in Wuhan and has been shown to have a wide spectrum of severity as SARS-CoV-2 binds to ACE2 receptors in 10-20 fold higher affinity than SARS-CoV binds to the same receptors.7,19 The report shows SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2.8 Therefore, it is necessary to further study whether lymphocytes have ACE2 receptor and TMPRSS2 expression during the developmental stage since the PLD exists. A SARS-CoV-2 RT-PCR assay for lymphocyte subsets in severe or critical cases should be followed up. Our findings also suggest that lymphocyte subsets should be analyzed at admission immediately no matter how COVID-19 affected lymphocytes through directly or indirectly. When patients are confirmed as COVID-19, clinicians should order tests for lymphocyte subsets in order to intervene early in the consequences of the PLD.
Conclusions
...The mortality rate is 4.6% in Wuhan, 1.9% in Beijing, and 0.9% in Shanghai. Our findings showed that the levels of lymphocytes were 0.8 (IQR, 0.6-1.1) 109/L in Wuhan, 1.0 (IQR, 0.7-1.4) 109/L in Beijing, and 1.1 (IQR, 0.8-1.5) 109/L in Shanghai before admission to hospitals, respectively, indicating that cellular immune function might relate to the mortality.
NOT PEER REVIEWED:
https://www.medrxiv.org/content/10.1101/2020.03.08.20031229v1.full.pdf
El Salvador went further, with President Nayib Bukele announcing late Wednesday the Central American country would ban entry to all foreigners for a period of 21 days.
The move would affect “any foreigner who is not a resident or diplomat” posted in the country, Bukele said, adding that Salvadorans arriving from countries hit by the virus would face a 30-day quarantine.
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If more countries had done this early on, it would have been a much better situation than we have now.
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