Posted on 08/26/2011 1:12:38 PM PDT by Swordmaker
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.
Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch
Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90
Published: 4 August 2011
Abstract (provisional)
It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
Thank you. There is always a naysayer to correct. ;-)
Your research and conclusions make a lot of sense to me. Thank you for the heads up on peroxide. I've been using 1.5% for an after-brushing (with toothpaste) rinse for several years now, and I had abandoned brushing with baking soda. I floss with Clean Paste by Reach before brushing.
That's all going to change today, but the horse may have left the barn since I'm 64 and have my Type II diabetes under control with diet and exercise.
I use a Sonicare toothbrush. Do you have an opinion about the type of toothbrush and whether an electric one is any better than manual?
Thanks for that input, Fred.
Thank you so much for this information! I have 3 questions. My husband and I have whole mouth restoration, Branemark implants, and I have teeth CM ceramics (Clinica Malo), (from Prosthodontics Intermedica with Dr. Balshi in Ft Washington, Pa.). There is a ring of teeth each for upper and lower that is screwed into the implants.
1 Would the bleach and baking soda be safe to use with the prosthesis?
2 Would using bleach change the color of the ceramic teeth and the plastic? material the teeth are set in?
3 I use a nightguard. It is made of hard plastic, but has plaque build up in places. What would your office recommend in so far as keeping it disinfected? Should I keep it in a bleach or baking soda solution?
Thank you so much for sharing this information with us, Swordfish!
RightWingLibrarian
Special thanks for the download link!
Interesting name morph. I’ll try to figure out how to slip that into a future Apple thread... ‘-)
>>Interesting name morph. I’ll try to figure out how to slip that into a future Apple thread... ‘-)
TXnMA,
I haven’t a clue what your post means.
RWL
If your theory has a weakness, it's probably this. I would guess that people who have spirochetes living happily in their mouths also have spirochetes living happily in their bodies. In other words it's a general, body-wide susceptibility to spirochetes that's the cause, with spirochetes in the mouth as one of the symptoms. By treating the mouth you're only treating a symptom. What's required is a systemic treatment, something like the antibiotic used for lyme disease. At least that is what seems likely to me.
I don't doubt that your recommendation of using baking soda to brush with is a good one, and probably will kill the spirochetes in the mouth, but I'll bet the ones in the body will continue to live there happily.
Also, why is it that the composition of the plaques is unknown? You mentioned that someone had speculated that they were accumulations of dead spirochete bodies, but hasn't this been proven or disproven already? It seems like the plaques' composition would have been thoroughly researched at this point.
It was a frequent event for one of the [prettier] girls on campus to show up (typically after a weekend, and commonly in the Spring) sporting a new "rock" on her left hand and gushing about how her beloved had recently proposed to her.Since they loved having their prized engagement rings admired, I enjoyed taking the recently betrothed lasses by the hand and leading them over to a window so I could marvel at the 'sparkle'...
Then I would say (gently tugging her hand closer to the window), "You know, real diamonds are the hardest thing in the world. Let's see if yours will scratch this window pane..."
Most of them would nearly yank my hand off in their panicked leap back from the window! And only a single one ever showed the understanding of relative Mohs harness (or the faith in her betrothed) to complete the experiment!! And that bold one insisted on doing the test herself. (Her diamond proved to be real -- and her fiance immediately got a big hug...)
At least a dozen others either mistrusted their betrothed's integrity or actually believed (as in the case under discussion here) the fallacy that a soft object can actually scratch or damage a harder one.
[Ain't ever happened, McGee...]
So, trisham -- be comforted that you certainly are not in a class all by yourself... '-) [But -- your (well-meaning, I'm sure) advice, in this context, was still dangerously wrong...]
Feel better now...? ;-)
~~~~~~~~~~~
FWIW, before I left the jewelers' with the diamond that my bride of fifty years still wears, I insisted on performing the test on it, myself.
And I often wondered how the conversations between those "unsure ladies" and their beloveds went following my "experiment"... ;-}
One thing for sure: if you can't trust your beloved to buy you a real diamond -- how can you entrust your entire future to him...???
The only thing you have to do is get the baking soda in where it can do its job. The small heads of the rotary power brushes don't carry much so I use a regular brush to load my teeth with the soda and then use the power brush—which is better for cleaning and getting down into the gums—for working it in.
Thank you for the information!!
Fantastic post, Swordmaker. Thanks.
I’d imagine the Clorox dilution would be even more fantastic if used in one’s Water-Pik. Gets into the gums that way!
. The baking soda absolutely. I can think of nothing that would prevent you from using the Dakin's 20 to 1 dilute bleach solution for two minutes , swishing it around your mounted prosthetic in your mouth that could harm it.
2 Would using bleach change the color of the ceramic teeth and the plastic? material the teeth are set in?
For the teeth, no. For the plastic, also no. Not at the concentration we are discussing.
3 I use a nightguard. It is made of hard plastic, but has plaque build up in places. What would your office recommend in so far as keeping it disinfected? Should I keep it in a bleach or baking soda solution?
Hmmmm.... Well, the only known chemical that will fairly safely dissolve plaque, without destroying the teeth or endangering the patient too much, is the Sodium Hypochlorite in bleach, and until you get under the plaque where the bugs like to hide, you really can't kill them all, I'd say you need to use the bleach judiciously on your nightguard until you've cleaned out the existing plaque. I'd do that with some slightly stronger dilution of bleach, maybe ten caps of water to one of bleach, with an old toothbrush and a toothpick and work at it by hand until I had it clean. Wear gloves with the stronger bleach because it does dissolve skin!
Once you've done that, store it in a baking soda bath. It'll be fresher to put in and you can stay ahead of the plaque build up on it by rinsing it once a week in the 20 to 1 solution. Remember that solution HAS to be made fresh every time. You can't keep it!
No big deal... Just that when you thanked me, my freep name had become "Swordfish" instead of "Swordmaker". He was making a funny, referencing the fact I keep the Mac/Apple PING list on FR. Swordmaker...
Thank you for answering so quickly. I love your comment about dumping large, poison rocks on the spirochetes.
No comment on it’s perhaps being too late because I’m so old? If I get dotty, I suppose I won’t care anyway, LOL!
The problem with your thinking on this, yardstick, is that the inside of your mouth is EXTERNAL to your body. It's OUTSIDE your skin! There are millions of bacteria inside your mouth you would NOT want living inside your body! We put many things in our mouths we would not want under our skin. Think of what a baby puts in it's mouth. The mouth is a very dirty place! The mouth is also the only place where the skeleton sticks THROUGH the skin.
There is a seal at the gums with a natural flow of fluid from your body out to prevent the movement of bacteria inward... But if that seal is broken, or the gums bleed, you open a superhighway into your body that the bacteria can enter. The surface area of that seal is about the size of the palm of your hand! If it gets compromised, it's a major problem!
The plaques are not unknown, but what starts them and what forms their core is. The "framework" cage that holds the cholesterol and fatty acids could be made up of the dead wirery, entangled bodies of millions of spirochetes that are very tough, attached to the artery and cell walls. These are transparent.
That's what we recommend.
My mom went back to using baking soda at 90, even though she had none in her mouth,so we're never to old!
So if I’m understanding you right, swordmaker, you’re saying the plaques, or at least the core of the plaques, are made of tangled masses of spirochete bodies but no one has noticed this fact. Presumably because all the researchers so far have used the wrong kind of microscope. Is this correct?
Placemark for an abslute Must Read!
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