Posted on 09/16/2021 5:57:27 PM PDT by Roman_War_Criminal
” Fauci, “let me sample that nipah for gain of function.” “
Fauci: “We must gain of function this virus, and aerosolize it in cans that look just like deodorant, so we can...uh...study it. Yeah, that’s it. Study it. So Science can protect all the stupid people. Yeah...study it. “
I’d be quarantining every population control freak on the books ... send ‘em all to Australia ... they’re already f***ed anyway.
No, this was named after a village in Malaysia.
“named after a village in Malaysia”
Well, we’ll just have to see what WHO says about that!
Welcome to your new ADE future, they just announced the new fear porn and the second part of their binary bioweapon.
ping!!
Yikes!
PING
PLEASE do not tell Fauci!
Turn loose the murder hornets!
Virus’s Achilles’ Heel Revealed
By Martin Enserink
ScienceNOW Daily News
18 February 2009
Vienna, Austria—Scientists have made a discovery about the basic biology of the Nipah virus, which suggests that cheap, existing drugs for high blood pressure and malaria may help fight the disease.
In Bangladesh, the virus appears to spread via date palm sap, which is collected overnight in clay pots tied around the tree trunk and sold fresh in the morning. Fruit bats are known to visit the trees to feed, and their urine and feces can end up in the pots.
No vaccines or drugs against Nipah exist. But now, a group led by Robin Buckland of INSERM in Lyons, France, may have found Nipah’s weak spot. Most researchers have assumed that the virus enters host cells through fusion between the cell’s plasma membrane and the virus’s envelope—a process that starts when a virus protein called G latches onto a host receptor called ephrinB2. But the INSERM team discovered that instead, the virus enters the cell through macropinocytosis, an ingestion process in which the cell membrane folds inward, engulfing the virus and its receptor in an intracellular vesicle.
Armed with that knowledge, the team tested out three drugs: Amiloride, which is used to treat hypertension and is known to block macropinocytosis; and the antimalarials chloroquine and hydroxychloroquine, which the team suspected might hamstring the virus because they raise the pH in intracellular compartments, including the vesicles created by macropinocytosis. In cell cultures, they found, all three drugs block viral replication efficiently. The team will start testing the drug in hamsters in a few weeks, says Olivier Pernet, a Ph.D. student in the group.
But tests in humans could begin even before the outcomes are known. “We’re very excited by these results,” says Stephen Luby, who studies Nipah at the International Centre for Diarrhoeal Disease Research in Bangladesh. Luby says he and others are already preparing a study protocol to try at least one of the drugs the next time Nipah strikes.
Given its high fatality rate and the fact that the drugs are quite safe, it probably would be unethical to conduct a randomized trial, in which half of the patients receive a placebo, Luby says. Instead, all of the patients that can be reached would receive treatment, he says, and their recovery rate would be compared with past experience.
This is a 2009 article and here is an interesting quote:
“Armed with that knowledge, the team tested out three drugs:
Amiloride, which is used to treat hypertension and is known to block macropinocytosis;
and the antimalarials chloroquine and hydroxychloroquine, which the team suspected might hamstring the virus because they raise the pH in intracellular compartments, including the vesicles created by macropinocytosis.
In cell cultures, they found, all three drugs block viral replication efficiently. “
Biology of Adenovirus Cell Entry
Stefania Luisoni, Urs F. Greber, in Adenoviral Vectors for Gene Therapy (Second Edition), 2016
4.2 Macropinocytosis
Macropinocytosis is the engulfment and uptake process of large amounts of fluids and membranes.
It occurs by actin-dependent membrane protrusion and retraction, and results in large intracellular vacuoles (>0.2 μM), referred to as macropinosomes, which can mature to late endosomes.
Constitutive macropinocytosis contributes to antigen presentation in macrophages and dendritic cells, and is widely exploited by pathogens to modulate the immune response.
Pinocytosis (Cell Drinking)
Pinocytosis (“pino” means “to drink”) is a process by which the cell takes in the fluids along with dissolved small molecules. In this process, the cell membrane folds and creates small pockets and captures the cellular fluid and dissolved substances.
I found this old article that ties high cholesterol and the cytokine storm response:
The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis
Yankun Li et al. J Leukoc Biol. 2007 Feb.
Is this the link between obese people and the higher deaths in Covid-19?
I hear that there is a clinic in Beijing which has a record of 100% cures for everybody who goes there with Nipah Virus infection.
I hope hundreds of the Nipah infected from India go there for treatment.Good for China in helping out the “Vorld!”
I’d be quarantining every population control freak on the books ... send ‘em all to Australia ... they’re already f***ed anyway.>>>>>>>>>>>>>>>>>>>
Not funny at all.
Oh, thanks.
Ok, can we just nuke all of Asia yet?
Biden White House: “We think we should import these infected people, for humanitarian reasons, into the United States. Only racists would object.”
Makes sense...
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