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Thalidomide teams-up with turmeric to kill myeloma cells
Chemistry World ^ | 2 July 2013 | Sonja Hampel

Posted on 07/02/2013 8:00:41 PM PDT by neverdem

One of the curcumin–thalidomide hybridsCancer researchers in the US and China have combined the turmeric spice pigment curcumin and the drug thalidomide to create hybrid compounds that can kill multiple myeloma cells.

Multiple myeloma is the second most common type of blood cancer, killing 20% of affected patients each year. The drug thalidomide, banned after causing birth defects when given during pregnancy in the 1950s, was recently rediscovered and approved for the treatment of multiple myeloma. Thalidomide works by disturbing the microenvironment of tumour cells in bone marrow. However, it disintegrates in the body. Curcumin, a yellow pigment from the common spice turmeric, is also active against cancers, including myeloma, but is limited by its poor water solubility.

Shijun Zhang at Virginia Commonwealth University, US, and colleagues, have synthesised compounds combining structural features from both thalidomide and curcumin. ‘The hybrids have enhanced solubility, and higher toxicity against myeloma cells than curcumin, thalidomide, or a mixture of both,’ explains Zhang, ‘so our design rational is going in the right direction.’ Zhang says the hybrids kill myeloma cells through combined mechanisms of action that include the generation of reactive oxygen species and cell cycle inhibition.

‘The advantage of the hybrid compounds is that they are stabilised, and do not degrade in the body as thalidomide does,’ says William Douglas Figg from the National Cancer Institute in Bethesda, US, who has conducted numerous studies and clinical trials with thalidomide derivatives. However, from his experience, compounds considered for further trials should be more toxic to myeloma cells.

In the meantime, one of Zhang’s hybrid compounds has shown activity against myeloma and prostate cancer in animal models.

References

K Liu et al, Org. Biomol. Chem., 2013, DOI: 10.1039/c3ob40595h


TOPICS: Culture/Society; News/Current Events
KEYWORDS: cancer; curcumin; health; multiplemyeloma; prostatecancer; thalidomide; turmeric
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1 posted on 07/02/2013 8:00:41 PM PDT by neverdem
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To: neverdem

Let’s hope they are onto something BIG!


2 posted on 07/02/2013 8:03:56 PM PDT by LuvFreeRepublic
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To: neverdem

Good post, u can’t PATENT straight-up curcumin, so they ligate it to this fancy stuff, so they can make big bucks.

Be aware that absorption of curcumin is very low —good to eat something really fatty in order to boost (typically low) absorption —cocunut oil, curry, whatevah.

Also add piperine or bioperine.

Cheap as hell, and effective.


3 posted on 07/02/2013 8:05:14 PM PDT by gaijin
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To: neverdem

Wow. This sounds like they may be on to something here.


4 posted on 07/02/2013 8:05:50 PM PDT by Lurkina.n.Learnin (President Obama; The Slumlord of the Rentseekers)
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To: neverdem

Ok, this is cool.


5 posted on 07/02/2013 8:06:36 PM PDT by Black Agnes
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To: neverdem

http://www.ncbi.nlm.nih.gov/pubmed/?term=curcumin+cancer


6 posted on 07/02/2013 8:08:28 PM PDT by gaijin
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To: Lurkina.n.Learnin

They could have done this years ago, but the Thalidomide angle made them too yellow.


7 posted on 07/02/2013 8:09:37 PM PDT by ClearCase_guy (21st century. I'm not a fan.)
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To: gaijin
Be aware that absorption of curcumin is very low —good to eat something really fatty in order to boost (typically low) absorption —cocunut oil, curry, whatevah.

Also add piperine or bioperine.
Hadn't heard of taking it with coconut oil (thanks!), but take it daily with black pepper. I use an extract from Natural News (a little more costly, but I think the stuff is great): http://store.naturalnews.com/Natural-Attitude-Turmeric-liquid-extract-2-fl-oz_p_125.html. (It helps with memory/thinking.)
8 posted on 07/02/2013 8:28:19 PM PDT by mlizzy (If people spent an hour a week in Eucharistic adoration, abortion would be ended. --Mother Teresa)
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To: gaijin
Also add piperine or bioperine.

Be careful with those if you are taking medications at the same time. Can result in unintended hyper-absorption of prescription drugs as well.

9 posted on 07/02/2013 8:33:22 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: FreedomOfExpression

BMFL


10 posted on 07/02/2013 8:35:08 PM PDT by FreedomOfExpression
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To: mlizzy

Another one is Boswellia Serrata —Frankensence to Bible-reading folks.

I chew it with bubble-gum.

Cheap as heck, and its the medicine we’ll have in 8 years, or so.

I usually use herbco.com —it’s wholesale.

http://www.herbco.com/c-364-frankincense.aspx


11 posted on 07/02/2013 8:36:13 PM PDT by gaijin
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To: neverdem

Well what do you know...Thalidomide causes defects in cancer cells and drives curcumin into them and they die...

I wonder if liposomal curcumin could be effective w/o the Thalidomide...

Liposomal vitamin C is easy to make at home and easily administered orally...it is as much as ten times more effective than IV-C against cancer.


12 posted on 07/02/2013 8:45:39 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders)
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To: gaijin
Another one is Boswellia Serrata —Frankensence to Bible-reading folks.
Yep! The stuff is awesome. Thanks for the link. We have purchased the essential oil from Young Living or Rocky Mountain Oils (little cheaper from RM, but not sure if the same quality). The stuff from YL has stopped fits of rage in seconds flat. Never seen anything like it!
13 posted on 07/02/2013 8:46:20 PM PDT by mlizzy (If people spent an hour a week in Eucharistic adoration, abortion would be ended. --Mother Teresa)
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To: GGpaX4DumpedTea
"I wonder if liposomal curcumin could be effective w/o the Thalidomide...

The vitamin docs all say tumeric is often an effective anti-cancer substance.

14 posted on 07/02/2013 8:49:50 PM PDT by cookcounty (IRS = Internal Revenge Service.)
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To: neverdem

15 posted on 07/02/2013 8:58:34 PM PDT by Vendome (Don't take life so seriously, you won't live through it anyway)
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To: cookcounty
The vitamin docs all say tumeric is often an effective anti-cancer substance.

And also an alzheimer's preventative. I find it's a brain stimulant, take it daily in organic form...from Organic India, a pricey but very reputable brand.

16 posted on 07/02/2013 8:59:08 PM PDT by Veto! (Opinions freely expressed as advice)
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To: neverdem

Turmeric can kill cancer cells without needing thalidomide. It is a natural anti-cancer compound, among other things beneficial.

Of course, if you want to prescribe a DRUG and CHARGE LOTS OF MONEY FOR IT, pair it up with thalidomide.


17 posted on 07/02/2013 8:59:13 PM PDT by Secret Agent Man (Gone Galt; Not averse to Going Bronson.)
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To: neverdem

I actually don’t see why they banned thalidomide.

There are two forms of thalidomide, a left handed chiral and a right handed chiral. One is safe, the other is the one that causes birth defects. Why they simply didn’t allow the one form that didn’t cause birth defects to remain the one to prescribe is kind of an over-reaction.


18 posted on 07/02/2013 9:01:21 PM PDT by Secret Agent Man (Gone Galt; Not averse to Going Bronson.)
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To: cookcounty

“...tumeric is often an effective anti-cancer substance...”

Yes, agreed. But why do you live in Cook County?


19 posted on 07/02/2013 9:05:49 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders)
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To: ClearCase_guy

That wuz my 1st thought.


20 posted on 07/02/2013 9:09:20 PM PDT by Vendome (Don't take life so seriously, you won't live through it anyway)
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To: neverdem

I remember the thalidomide babies of the 1960s. Abortion got a big push when some woman from the US was pregnant, used thalidomide, then was afraid the child would be deformed.

I remember the magazines then showing this extremely stressed out woman, while mentioning that abortions were not legal in the US.

She later went to Sweden and got her abortion.


21 posted on 07/02/2013 10:07:14 PM PDT by Ruy Dias de Bivar (Sometimes you need 7+ more ammo. LOTS MORE.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
3-drug combination stabilizes new onset of type-2 diabetes

Fat Cells Feel the Cold, Burn Calories for Heat

Drug Appears To Work For Weight-Loss In U-M Study

Microscopic 'Tuning Forks' Could Make the Difference Between Life and Death in the Hospital

FReepmail me if you want on or off my health and science ping list.

22 posted on 07/02/2013 10:32:10 PM PDT by neverdem (Register pressure cookers! /s)
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To: gaijin

Thanks for the link.


23 posted on 07/02/2013 10:34:08 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem

bflr


24 posted on 07/02/2013 11:08:52 PM PDT by notatard?
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To: gaijin

Thanks, good advice.


25 posted on 07/02/2013 11:58:14 PM PDT by fortheDeclaration (Pr 14:34 Righteousness exalteth a nation:but sin is a reproach to any people)
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To: neverdem

one of my myeloma patients was put on thalidomide, and that was a couple of years ago, so that’s not exactly new.

It is also used for leprosy patients.

Because of the danger to a fetus, they have to be very careful about using the medicine.


26 posted on 07/02/2013 11:58:24 PM PDT by LadyDoc (liberals only love politically correct poor people)
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To: cookcounty

I always wondered about turmeric. Everyone in my Grandparent’s generation (in my family) lived well into their 90’s. All of them were raised on farms; all of them canned and pickled everything.

I spent quite a bit of time thinking about what they “ate” that might have been significantly different than our usual daily diet. Aside from the obvious fact that the food was not generally highly processed...I came up with “pickled things” most of which contained Turmeric; and cottage cheese...both of which were served at nearly every meal.


27 posted on 07/03/2013 12:13:16 AM PDT by garandgal
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To: mlizzy
Hadn't heard of taking it with coconut oil (thanks!), but take it daily with black pepper. I use an extract from Natural News

I take my tumeric as well as capsicum with two tablespoons of coconut oil. I'm keto adapted, so the coconut oil is like pouring gasoline into a fire and I can feel the cardio nutrition from the capsicum within seconds.

28 posted on 07/03/2013 3:31:24 AM PDT by RobertClark (My shrink just killed himself - he blamed me in his note!)
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To: neverdem

bttt


29 posted on 07/03/2013 6:26:05 AM PDT by GOPJ (... liberal anger - - the privileged wheeze of entitled brats ... Greenfield)
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To: Ruy Dias de Bivar
"She later went to Sweden and got her abortion."

This needs a "the rest of the story" addendum. "Was" the aborted fetus (aka "baby") actually deformed??

30 posted on 07/03/2013 6:55:43 AM PDT by Wonder Warthog
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To: Wonder Warthog

***This needs a “the rest of the story” addendum. “Was” the aborted fetus (aka “baby”) actually deformed?? ***

According to the Swedish doctor, yes, it was deformed.

http://opinionator.blogs.nytimes.com/2012/09/05/a-never-ending-story/?_r=0

http://en.wikipedia.org/wiki/Sherri_Finkbine


31 posted on 07/03/2013 7:01:27 AM PDT by Ruy Dias de Bivar (Sometimes you need 7+ more ammo. LOTS MORE.)
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To: gaijin

I take one capsule of Turmeric daily (about 550 mg) for cancer prevention, primarily skin cancer. I have read that it can help.

Should I take more than that?


32 posted on 07/03/2013 7:37:09 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: gaijin

This is a “standardized” vitamin, is that okay?

http://www.vitacost.com/vitacost-turmeric-extract-curcumin-c3-complex-with-bioperine-1160-mg-per-serving-60-capsules-1#BVRRWidgetID


33 posted on 07/03/2013 7:48:04 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: neverdem

I have been adding turmeric capsules to my diet for about a year
I STRONGLY RECOMMEND IT!!!!!

you know you are taking enough if you start to crave PEPPER on everything (instead of salt)


34 posted on 07/03/2013 7:51:29 AM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: Vendome

ok what is that? it looks delicious


35 posted on 07/03/2013 7:53:01 AM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: gaijin

you have to eat ordinary table PEPPER to boost turmeric absorption


36 posted on 07/03/2013 7:54:09 AM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: RobertClark

how do you take the coconut oil? I assume not by the spoonful (yuck!)


37 posted on 07/03/2013 7:55:52 AM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: gaijin

Are those herbs in supplement form?

Sorry, I’m bombarding you with questions. It’s just that theres been a lot of cancer in my family and I’m trying to “save” the rest of us!


38 posted on 07/03/2013 7:58:16 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: RobertClark

That’s awesome, thanks for sharing!!!


39 posted on 07/03/2013 8:02:37 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: Mr. K

Tilapia in turmeric


40 posted on 07/03/2013 8:13:53 AM PDT by Vendome (Don't take life so seriously, you won't live through it anyway)
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To: Mr. K

Depending on the brand (I buy mine from my naturopath - it doesn’t smell or taste like coconut), I can either drink it straight or I put it in my coffee.

I just wanted to throw out some other supplements that have anti-cancer properties to them: Vitamin D, Selenium, ALA, Iodine & Magnesium. In addition to these, Green Tea Extract and Resveratrol Grape Seed & Red Wine Extracts.


41 posted on 07/03/2013 8:14:32 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: diamond6

Driving now but at noon PST I will b behind a computer and will give thoroughanswer and more, no prob.


42 posted on 07/03/2013 8:35:16 AM PDT by gaijin
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To: neverdem

BTTT!


43 posted on 07/03/2013 10:11:44 AM PDT by Salvation ("With God all things are possible." Matthew 19:26)
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To: Mr. K
how do you take the coconut oil?

I do take it by the spoonful, sometimes I mix it with scrambled eggs.

44 posted on 07/03/2013 1:24:21 PM PDT by RobertClark (My shrink just killed himself - he blamed me in his note!)
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To: RobertClark

Thank you for this information! I too take cayenne pepper [extract], but since I battle Graves Disease (hyperthyroid), I avoid coconut oil, but I’m going to find out if I need to avoid it completely.


45 posted on 07/03/2013 2:35:05 PM PDT by mlizzy (If people spent an hour a week in Eucharistic adoration, abortion would be ended. --Mother Teresa)
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To: neverdem

BookMark


46 posted on 07/03/2013 2:35:35 PM PDT by thesearethetimes... ("Courage, is fear that has said its prayers." Dorothy Bernard)
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bookmark


47 posted on 07/03/2013 3:19:38 PM PDT by PrivateIdaho ( "Courage is being scared to death... but saddling up anyway." (John Wayne))
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To: diamond6
I take one capsule of Turmeric daily (about 550 mg) for cancer prevention, primarily skin cancer. I have read that it can help. Should I take more than that?

OK the short answer is that I think u should take TWO, not one, and here is the more important thing:

Take those along with your fattiest meal of the day --for most folks that's dinner. Lessay you eat a bunch of lasagna? Yeah, take it with that.

Or lessay you eat a huge omlette with plenty of butter --take it then.

Whatever you eat that is super fatty --and I know you eat fats-- you take your curcumin (tumeric, but the active component) THEN.

While it's super cheap and super therapeutic it's bioavailability is pretty low --just cuz it gets past your lips does not at all mean that it is getting uptaken.

Also it does not circulate for a long time --all the expensive efforts to ligate curcumin to other bigger things have the objective of making it patentable ($$$) and maybe also get it to circulate for a longer time b4 being eliminated.

I really think the best --for years-- will be to consistently take pure curcumin with something fatty and peppery.

And you should try the frankensense/gum thing I described --it's cheap, simple, reliable, and highly thereapeutic.

I'm not super Biblical, but here is a quick aside;

1. gold - resists inflation
2. Myrrh - anti parasitic, anti-helmenthic
3. Frankensence - powerful anti-inflammatory (and many others)

48 posted on 07/03/2013 3:30:36 PM PDT by gaijin
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To: RobertClark

can you cook with it?
I have a jar, I haven’t used it for anything yet

I cannot imagine trying to swallow a spoonful of it- it looks like hardened lard - do you use something different?


49 posted on 07/03/2013 3:55:19 PM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: gaijin

Thank you!


50 posted on 07/03/2013 4:13:32 PM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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