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Thalidomide teams-up with turmeric to kill myeloma cells
Chemistry World ^ | 2 July 2013 | Sonja Hampel

Posted on 07/02/2013 8:00:41 PM PDT by neverdem

One of the curcumin–thalidomide hybridsCancer researchers in the US and China have combined the turmeric spice pigment curcumin and the drug thalidomide to create hybrid compounds that can kill multiple myeloma cells.

Multiple myeloma is the second most common type of blood cancer, killing 20% of affected patients each year. The drug thalidomide, banned after causing birth defects when given during pregnancy in the 1950s, was recently rediscovered and approved for the treatment of multiple myeloma. Thalidomide works by disturbing the microenvironment of tumour cells in bone marrow. However, it disintegrates in the body. Curcumin, a yellow pigment from the common spice turmeric, is also active against cancers, including myeloma, but is limited by its poor water solubility.

Shijun Zhang at Virginia Commonwealth University, US, and colleagues, have synthesised compounds combining structural features from both thalidomide and curcumin. ‘The hybrids have enhanced solubility, and higher toxicity against myeloma cells than curcumin, thalidomide, or a mixture of both,’ explains Zhang, ‘so our design rational is going in the right direction.’ Zhang says the hybrids kill myeloma cells through combined mechanisms of action that include the generation of reactive oxygen species and cell cycle inhibition.

‘The advantage of the hybrid compounds is that they are stabilised, and do not degrade in the body as thalidomide does,’ says William Douglas Figg from the National Cancer Institute in Bethesda, US, who has conducted numerous studies and clinical trials with thalidomide derivatives. However, from his experience, compounds considered for further trials should be more toxic to myeloma cells.

In the meantime, one of Zhang’s hybrid compounds has shown activity against myeloma and prostate cancer in animal models.

References

K Liu et al, Org. Biomol. Chem., 2013, DOI: 10.1039/c3ob40595h


TOPICS: Culture/Society; News/Current Events
KEYWORDS: cancer; curcumin; health; multiplemyeloma; prostatecancer; thalidomide; turmeric
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To: Mr. K

Depending on the brand (I buy mine from my naturopath - it doesn’t smell or taste like coconut), I can either drink it straight or I put it in my coffee.

I just wanted to throw out some other supplements that have anti-cancer properties to them: Vitamin D, Selenium, ALA, Iodine & Magnesium. In addition to these, Green Tea Extract and Resveratrol Grape Seed & Red Wine Extracts.


41 posted on 07/03/2013 8:14:32 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: diamond6

Driving now but at noon PST I will b behind a computer and will give thoroughanswer and more, no prob.


42 posted on 07/03/2013 8:35:16 AM PDT by gaijin
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To: neverdem

BTTT!


43 posted on 07/03/2013 10:11:44 AM PDT by Salvation ("With God all things are possible." Matthew 19:26)
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To: Mr. K
how do you take the coconut oil?

I do take it by the spoonful, sometimes I mix it with scrambled eggs.

44 posted on 07/03/2013 1:24:21 PM PDT by RobertClark (My shrink just killed himself - he blamed me in his note!)
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To: RobertClark

Thank you for this information! I too take cayenne pepper [extract], but since I battle Graves Disease (hyperthyroid), I avoid coconut oil, but I’m going to find out if I need to avoid it completely.


45 posted on 07/03/2013 2:35:05 PM PDT by mlizzy (If people spent an hour a week in Eucharistic adoration, abortion would be ended. --Mother Teresa)
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To: neverdem

BookMark


46 posted on 07/03/2013 2:35:35 PM PDT by thesearethetimes... ("Courage, is fear that has said its prayers." Dorothy Bernard)
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bookmark


47 posted on 07/03/2013 3:19:38 PM PDT by PrivateIdaho ( "Courage is being scared to death... but saddling up anyway." (John Wayne))
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To: diamond6
I take one capsule of Turmeric daily (about 550 mg) for cancer prevention, primarily skin cancer. I have read that it can help. Should I take more than that?

OK the short answer is that I think u should take TWO, not one, and here is the more important thing:

Take those along with your fattiest meal of the day --for most folks that's dinner. Lessay you eat a bunch of lasagna? Yeah, take it with that.

Or lessay you eat a huge omlette with plenty of butter --take it then.

Whatever you eat that is super fatty --and I know you eat fats-- you take your curcumin (tumeric, but the active component) THEN.

While it's super cheap and super therapeutic it's bioavailability is pretty low --just cuz it gets past your lips does not at all mean that it is getting uptaken.

Also it does not circulate for a long time --all the expensive efforts to ligate curcumin to other bigger things have the objective of making it patentable ($$$) and maybe also get it to circulate for a longer time b4 being eliminated.

I really think the best --for years-- will be to consistently take pure curcumin with something fatty and peppery.

And you should try the frankensense/gum thing I described --it's cheap, simple, reliable, and highly thereapeutic.

I'm not super Biblical, but here is a quick aside;

1. gold - resists inflation
2. Myrrh - anti parasitic, anti-helmenthic
3. Frankensence - powerful anti-inflammatory (and many others)

48 posted on 07/03/2013 3:30:36 PM PDT by gaijin
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To: RobertClark

can you cook with it?
I have a jar, I haven’t used it for anything yet

I cannot imagine trying to swallow a spoonful of it- it looks like hardened lard - do you use something different?


49 posted on 07/03/2013 3:55:19 PM PDT by Mr. K (There are lies, damned lies, statistics, and democrat talking points.)
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To: gaijin

Thank you!


50 posted on 07/03/2013 4:13:32 PM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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To: Mr. K

Coconut oil is incredible for cooking. It would be lousy for high-temp frying, but that is usually not a problem, as people who gravitate toward it tend to not desire deep fried solutions. It is incredible for anything where you would typically use butter or another oil. Coconut oil is what they used to pop popcorn with at the theaters - back when it tasted reaalllllly good. I scramble eggs with it, use it to saute veg, the uses are endless. The medium chain triglycerides are incredibly under-rated and critical. One note, though, it is a peculiar oil in that it solidifies below 76 degrees, so it can be liquid during one use and solid the next time you grab it.


51 posted on 07/03/2013 4:14:05 PM PDT by RobertClark (My shrink just killed himself - he blamed me in his note!)
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To: neverdem

bfl


52 posted on 07/05/2013 4:04:33 PM PDT by FreedomPoster (Islam delenda est)
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To: Secret Agent Man

Yep, and so few people knew/know that. The trouble is news reporters cannot be bothered and bureaucrats are fearful and slothful. They’re the anti-entrepreneurs.


53 posted on 07/06/2013 6:03:41 AM PDT by 1010RD (First, Do No Harm)
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To: gaijin; neverdem

1. Turmeric

Curcumin, possibly the most powerful antioxidant known from the popular Indian spice Turmeric, has countless health benefits. A recent study led by a research team in Munich showed that it can also inhibit formation of metastases.

Curcumin exerts anti-inflammatory and anti-oxidative effects by inhibiting tumor necrosis factor-alpha (TNF-alpha), suggesting that its effect on endothelial function may be mediated by the suppression of inflammation and/or oxidative stress via down-regulation of TNF-alpha.

One of the most comprehensive summaries of a review of 700 turmeric studies to date was published by the respected ethnobotanist James A. Duke, Phd. He showed that turmeric appears to outperform many pharmaceuticals in its effects against several chronic, debilitating diseases, and does so with virtually no adverse side effects.

Read more at http://www.realfarmacy.com/5-foods-that-kill-cancer/#wFeopfyUZubZhJrw.99


54 posted on 07/07/2013 11:57:20 AM PDT by diamond6 (Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)
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