Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

New Depression Findings Could Alter Treatments
NY Times ^ | August 8, 2006 | BENEDICT CAREY

Posted on 08/11/2006 9:01:19 PM PDT by neverdem

The results of two new studies may signal a substantial shift in the way psychiatrists and researchers think about treatment for severely depressed patients.

--snip--

In the other, psychiatrists in New York found evidence that antidepressant drugs significantly increased the risk that some children and adolescents would attempt or commit suicide. Doctors have debated this risk for years, but the authors of the study were skeptical of it, and their report may sway others.

--snip--

The study of suicide risk, led by Dr. Mark Olfson of Columbia University and the New York State Psychiatric Institute, was based on an analysis of Medicaid records of more than 4,400 people who were hospitalized for depression in 1999 and 2000.

--snip--

But children and adolescents in the study who were taking antidepressants were about 50 percent more likely than those not on the drugs to try to kill themselves. And they were about 15 times as likely as those not on the medications to complete the act, although the number of suicides was too small to draw definitive conclusions, the authors cautioned.

In addition, there could be differences between the two groups that the Medicaid records didn’t reveal: the children who received the drugs may have been more severely ill, skewing the results, they said.

In 2004, the Food and Drug Administration required strong warnings on the labels of antidepressant drugs alerting parents and doctors of a possible suicide risk in some children. Since then many psychiatrists have been skeptical of the suicide link.

“I was surprised by what we found,” Dr. Olfson said. “I set out thinking we’d find that the drugs” significantly reduced suicide risk.

The findings may prompt researchers to look at which children are most at risk, rather than continuing to debate whether the risk exists, he said.

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Extended News; News/Current Events; US: New York
KEYWORDS: antidepressants; depression; disorders; drugs; health; ketamine; medicine; mentaldisorders; mentalhealth; pharmaceuticals; psychiatry; ssri; suicideattempts; suicides
Navigation: use the links below to view more comments.
first 1-5051-73 next last
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

Antidepressant Drug Therapy and Suicide in Severely Depressed Children and Adults

1 posted on 08/11/2006 9:01:22 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

It is depressing - so depressing, in fact, one couldn't fail to start another 6-pack.


2 posted on 08/11/2006 9:06:42 PM PDT by GSlob
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
But children and adolescents in the study who were taking antidepressants were about 50 percent more likely than those not on the drugs to try to kill themselves. And they were about 15 times as likely as those not on the medications to complete the act, although the number of suicides was too small to draw definitive conclusions, the authors cautioned.

The problem here is that the depressed are more likely to commit suicide or other self destructive acts.

Those receiving anti-depressant medication are therefore deemed more depressed than others and therefore, more likely to commit suicide.

3 posted on 08/11/2006 9:10:13 PM PDT by fso301
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

4 posted on 08/11/2006 9:11:07 PM PDT by Nick Danger (www.redeploymurtha.com)
[ Post Reply | Private Reply | To 1 | View Replies]

To: fso301

At least 30 years ago this was known. It was thought then that the drugs created enough lift to help them perform the act. Another reason could be that irregular doses create withdrawal, a worse depression.


5 posted on 08/11/2006 9:15:38 PM PDT by sine_nomine (Confidential to Bush: protect the borders. The first word in "illegal immigrant" is...?)
[ Post Reply | Private Reply | To 3 | View Replies]

To: fso301

I second that. Another thing I have read is that those who just start taking anti-depressant medication are more likely to commit suicide. One hypothesis is that medication can also elevate energy levels. Should the medication do that before helping with the depression, a suicidal but tired person might suddenly find the energy to kill himself.


6 posted on 08/11/2006 9:18:24 PM PDT by psychoknk
[ Post Reply | Private Reply | To 3 | View Replies]

To: sine_nomine
Another reason could be that irregular doses create withdrawal, a worse depression.

I'm sure there is a lot to that. Before someone takes a product like that they need to understand that they are taking something that can affect their judgment and they need to follow the instructions to the letter...and that includes not drinking alcohol...which tends to be advice not followed.
7 posted on 08/11/2006 9:22:12 PM PDT by P-40 (Al Qaeda was working in Iraq. They were just undocumented.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: fso301
The problem here is that the depressed are more likely to commit suicide or other self destructive acts.

True, but that wasn't found with adults taking these SSRIs. From the 2nd link in comment# 1:

"In adults (aged 19-64 years), antidepressant drug treatment was not significantly associated with suicide attempts (odds ratio [OR], 1.10; 95% confidence interval [CI], 0.86-1.39 [521 cases and 2394 controls]) or suicide deaths (OR, 0.90; 95% CI, 0.52-1.55 [86 cases and 396 controls])."

8 posted on 08/11/2006 9:40:16 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: neverdem
Study refutes link between suicide risk, antidepressants
9 posted on 08/11/2006 10:03:18 PM PDT by MarMema
[ Post Reply | Private Reply | To 1 | View Replies]

To: MarMema
Thanks for the link, although its title seems to be at odds with at least one of its paragraphs, which supports the extra concern for kids.

"Adolescents in the study had more suicide attempts than adults. The researchers found that the rate for the first six months of antidepressant treatment was 314 attempts per 100,000 in teens and 78 attempts per 100,000 in adults. As with adults, the rate was highest in the month before treatment and declined by about 60 percent after treatment began."

10 posted on 08/11/2006 10:18:25 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 9 | View Replies]

To: psychoknk

The article mentions suicide but what about the people who go bonkers and kill other people (with or without the incident ending in suicide)? There are many anecdotes about people on anti-depressant drugs doing such horrible crimes. I have long been of the opinion that the mindset to commit suicide and the mindset to commit murder are similar, and that if some medicines make it easier for someone to commit suicide, the same medicines might make it easier for a disturbed person to commit murder. That's just my unscientific opinion developed by watching the news over the years.


11 posted on 08/11/2006 11:36:35 PM PDT by Wilhelm Tell (True or False? This is not a tag line.)
[ Post Reply | Private Reply | To 6 | View Replies]

To: neverdem

So when do we start filing criminal charges against those responsible for this incredibly widespread child abuse? Any Senate hearings scheduled?


12 posted on 08/12/2006 12:22:26 AM PDT by thoughtomator (Bring Back HCUA!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

We know that stimulants can affect youngsters differently than adults, no reason to believe SSRI's can't act in a similar fashion.

I've always felt that any serious medication should be administered with restraint to those under a certain age. Children aren't tiny adults, and the physicians should know that.


13 posted on 08/12/2006 12:27:47 AM PDT by stands2reason (ANAGRAM for the day: Socialist twaddle == Tact is disallowed)
[ Post Reply | Private Reply | To 8 | View Replies]

To: Wilhelm Tell; psychoknk
The article mentions suicide but what about the people who go bonkers and kill other people (with or without the incident ending in suicide)? There are many anecdotes about people on anti-depressant drugs doing such horrible crimes. I have long been of the opinion that the mindset to commit suicide and the mindset to commit murder are similar, and that if some medicines make it easier for someone to commit suicide, the same medicines might make it easier for a disturbed person to commit murder. That's just my unscientific opinion developed by watching the news over the years.

ANTIDEPRESSANT CASUALTIES

14 posted on 08/12/2006 12:34:18 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 11 | View Replies]

To: fso301
the depressed are more likely to commit suicide

I think what will ultimately be discovered is that there's a group of depressed suicidal patients whose depression is so disabling that they're unable to carry out their self-destructive desire. As they begin to respond to the anti-depressants they recover their ability to act before they lose their desire to act.

Essentially, we're taking suicidal people who lack the energy to kill themselves and making them more energetic.... with predictable results. Sort of like giving taxi fare to the nearest span to a broke bridge-jumper.

15 posted on 08/12/2006 12:46:03 AM PDT by ArmstedFragg
[ Post Reply | Private Reply | To 3 | View Replies]

To: ArmstedFragg

Damn pills. Flush them all. Get up and go do some yard work, for heaven's sake. Works for me.


16 posted on 08/12/2006 3:27:43 AM PDT by CalvaryJohn (What is keeping that damned asteroid?)
[ Post Reply | Private Reply | To 15 | View Replies]

To: Wilhelm Tell
I have long been of the opinion that the mindset to commit suicide and the mindset to commit murder are similar

You'd find a whale of a lot more people with suicidal wishes than murder wishes.

17 posted on 08/12/2006 3:29:37 AM PDT by HiTech RedNeck
[ Post Reply | Private Reply | To 11 | View Replies]

To: ArmstedFragg

All this crude talk about "energizing" is like unto the way the old natural philosophers thought of fire, air, earth, and water. Nobody has even begun to reverse engineer the marvel we know as "thinking."


18 posted on 08/12/2006 3:31:34 AM PDT by HiTech RedNeck
[ Post Reply | Private Reply | To 15 | View Replies]

In the other, psychiatrists in New York found evidence that antidepressant drugs significantly increased the risk that some children and adolescents would attempt or commit suicide.

It's too late for my Brother. He ate a .44 bullet Monday morning in his backyard behind a tree.
I'm still trying to get through this, and this is the first I've mentioned it on FR.
But these damn doctors must stop with simply prescribing drugs to their patients and TALK TO THEM!

/rant

19 posted on 08/12/2006 3:34:21 AM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 1 | View Replies]

To: GSlob

Have we heard from Tom Cruise on this yet?


20 posted on 08/12/2006 3:51:29 AM PDT by strider44
[ Post Reply | Private Reply | To 2 | View Replies]

To: RandallFlagg

Sorry for your loss. My best friend's brother killed himself a couple of years ago the same way. His girlfriend had just broken up with him. It's devastating to any family and I know you'll be asking "why?" for years to come. You have my sympathy.


21 posted on 08/12/2006 4:00:01 AM PDT by strider44
[ Post Reply | Private Reply | To 19 | View Replies]

To: neverdem
Jeez. Anybody with half a brain has KNOWN THIS as FACT for 20 years or more!!!!! Why does it take so long for the Rx's to get it??? Bloody well WED to ERROR> ARGGGG.

oh...non-prescription therapy don't pay the dock fees.

22 posted on 08/12/2006 4:04:03 AM PDT by dasboot
[ Post Reply | Private Reply | To 1 | View Replies]

To: strider44

Thank you.


23 posted on 08/12/2006 4:11:34 AM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 21 | View Replies]

To: RandallFlagg

Just this past Monday? I'd be in far too much shock to tie my shoes let alone freep.


24 posted on 08/12/2006 4:13:50 AM PDT by HiTech RedNeck
[ Post Reply | Private Reply | To 19 | View Replies]

To: HiTech RedNeck

Yep.
I'm more concerned for my G'Ma and Mom. They were living with him and they both found his body.


25 posted on 08/12/2006 4:16:44 AM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 24 | View Replies]

To: RandallFlagg

Sorry to hear that...


26 posted on 08/12/2006 4:24:12 AM PDT by dynoman (Objectivity is the essence of intelligence. - Marylin vos Savant)
[ Post Reply | Private Reply | To 19 | View Replies]

To: dasboot

What non-prescription therapy??

What you hear about these drugs can be scary, one maybe should remember most will talk about bad side effects but ont the good ones.


27 posted on 08/12/2006 4:26:55 AM PDT by dynoman (Objectivity is the essence of intelligence. - Marylin vos Savant)
[ Post Reply | Private Reply | To 22 | View Replies]

To: dynoman
Can't agree that there are any lasting, good effects of psychotheraputic drugs. At best, they provide a fresh coat of paint on a house full of termites. The house falls anyway...sometimes faster.

There is not one chemical compound that I'm am aware of that does not include 'long term, irreversable brain damage' in its list of contraindications in the PDF.

I base my admittedly empirical conclusions upon years of documenting and investigating unattended deaths...including suicides, and years of running a muni lockup...intake and monitoring of arrestees. Then there are the many acquantences and friends who, through the years, have had experiences related to Ritalin and other compounds used on their children, and the long term effects and results of that therapy.

I'm always curious; I ask questions. I've not seen or heard of a productive consequence of drug therapy. Not once...except in short term circumstances...which, unavoidably, went south, in time. Reputed successes are, as far as my prejudices will allow, to be had DESPITE the use of the drugs.

28 posted on 08/12/2006 1:33:43 PM PDT by dasboot
[ Post Reply | Private Reply | To 27 | View Replies]

To: dasboot

I'd love to talke to you more about this.

"There is not one chemical compound that I'm am aware of that does not include 'long term, irreversable brain damage' in its list of contraindications in the PDF. "

Does this include the SSRIs like lexapro, zoloft prozac etc??

What about St John's Wort (or other "natural" serotonin uptake inhibitors) for depression?


29 posted on 08/12/2006 1:55:50 PM PDT by dynoman (Objectivity is the essence of intelligence. - Marylin vos Savant)
[ Post Reply | Private Reply | To 28 | View Replies]

To: dynoman
I'll consult the PDF later tonight, and get back at you. There's probably an on line version!

These references I allude to are the result of periodic consultation over the years to look at specific things, and I don't pretend to be an authority. I can sometimes guess correctly the drug and length of time taken by what I observe in an incoming arrestee. This ain't exactly scientific.....but you notice things after a while. And through the years, I get to see the same clients periodically, and observe their progress; and I always inquire, for my own purposes, the status of their treatment. Not part of my job, per se, but it gives us something to chat about. (although I like to know if they're feeling like killing themselves...that is part of my job...keep 'em alive long enough to see the judge)

30 posted on 08/12/2006 2:59:36 PM PDT by dasboot
[ Post Reply | Private Reply | To 29 | View Replies]

To: dasboot

Thanks very much...

What's the PDF?

There seems to be nowhere to turn if you don't want to use SSRIs for depression. I did read that in Germany the vast majority of mild to mid level depression is treated with St John's wort Prozac has 2%.


31 posted on 08/12/2006 4:07:13 PM PDT by dynoman (Objectivity is the essence of intelligence. - Marylin vos Savant)
[ Post Reply | Private Reply | To 30 | View Replies]

To: RandallFlagg
Hello,

I am so sorry to hear about your brother, my prayers are with you and your family...

MOgirl
32 posted on 08/12/2006 4:10:55 PM PDT by MOgirl (Democrats: The Culture of Treason (and you know what I'm talkin about!))
[ Post Reply | Private Reply | To 19 | View Replies]

To: dynoman

Physicians' Desk Reference.


33 posted on 08/12/2006 4:36:03 PM PDT by dasboot
[ Post Reply | Private Reply | To 31 | View Replies]

To: dasboot

slip of finger...sorry


34 posted on 08/12/2006 4:39:17 PM PDT by dasboot
[ Post Reply | Private Reply | To 33 | View Replies]

To: dasboot

Ha! PDF..twice...slip of brain. Double sorry. PDR PDR PDR...


35 posted on 08/12/2006 4:41:50 PM PDT by dasboot
[ Post Reply | Private Reply | To 34 | View Replies]

To: RandallFlagg

Oh my! Prayers for you and your family. I can't imagine the pain you must be feeling right now.

Please keep on FReeping. You know you have A LOT of support here. God bless you during this awful, terrible time.


36 posted on 08/12/2006 4:59:31 PM PDT by mplsconservative
[ Post Reply | Private Reply | To 19 | View Replies]

To: MOgirl; mplsconservative; All

Thank you both. Thank you all.
I'm just trying to get back in the saddle. My family needs me to stay strong. So far, so good.


37 posted on 08/12/2006 7:51:42 PM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 32 | View Replies]

To: dynoman

Thank you.


38 posted on 08/12/2006 7:52:44 PM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 26 | View Replies]

To: RandallFlagg; Pegita

We need some prayer warriors for our FRiend Randall here. His loss is great.

Pegita, I humbly ask that you ping your lists.


39 posted on 08/12/2006 8:54:49 PM PDT by mplsconservative
[ Post Reply | Private Reply | To 37 | View Replies]

To: CalvaryJohn

I make sure I take my B-100, and my multiple vitamin every day. Coffee helps, and I'm good to go.

I pull weeds, prune roses trim shrubbery, and just get moving into life.

Everyone can be depressed if all we do is sit around and watch TV, becoming so self absorbed, depression will set right in.

I'm up every morning at 4:45. I work and don't have time for that kind of thing.


40 posted on 08/12/2006 9:00:32 PM PDT by television is just wrong (our sympathies are misguided with illegal aliens...)
[ Post Reply | Private Reply | To 16 | View Replies]

To: mplsconservative

Actually, please send them to my Mom and Grandma. He lived with them, and they are the ones who found him in the backyard Monday morning.


41 posted on 08/12/2006 10:07:45 PM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 39 | View Replies]

To: neverdem

How about, "Were More Likely to Commit Violent Acts"?


42 posted on 08/12/2006 10:15:08 PM PDT by aruanan
[ Post Reply | Private Reply | To 1 | View Replies]

To: dasboot

They knew it back when I studied at that same distinguished institution. It was hammered into our brains that anyone recovering from depression was more likely to commit suicide during the upswing than at any other time. Adolescence is the most dangerous age for depression, given the massive changes and confusion and pressure on the teenage mind.


43 posted on 08/12/2006 10:16:18 PM PDT by The Westerner
[ Post Reply | Private Reply | To 22 | View Replies]

To: RandallFlagg

I'm really sorry to read about your loss. May I ask how old he was? FWIW, prayer offered.


44 posted on 08/12/2006 10:34:00 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 19 | View Replies]

To: neverdem

He was 38 April 27th.


45 posted on 08/12/2006 10:36:07 PM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 44 | View Replies]

To: RandallFlagg; mplsconservative; trussell; Cindy; Kitty Mittens; Brad's Gramma
Unto You, O Lord, we return with thanksgiving that we can gather around Randy and his family in their time of great loss. Touch the depths of their grieving hearts with a Comfort beyond human understanding, so deep is their devastation and need. May the death of Randy's brother bring about needed changes in treatment, for You are not willing that any should perish. Cause us to look to You, O Lord, in faith even in times when we have not understanding, for no matter the circumstance, You never leave nor forsake. For this we praise You, in the Name of our Lord Jesus Christ, Amen ...
46 posted on 08/13/2006 6:24:13 AM PDT by Pegita ('Tis so sweet to trust in Jesus, just to take Him at His Word ...)
[ Post Reply | Private Reply | To 19 | View Replies]

To: neverdem

*


47 posted on 08/13/2006 6:26:12 AM PDT by Sam Cree (Don't mix alcopops and ufo's)
[ Post Reply | Private Reply | To 1 | View Replies]

To: dynoman

"What about St John's Wort (or other "natural" serotonin uptake inhibitors) for depression?"

Tryptophan is a pre-cursor to serotonin. The good thing is that it adds serotonin but doesn't change the feedback part of the process (i.e., the re-Uptake part) so it isn't as likely to change a very complicated process in the brain over time.

From what I have read lots of people have been helped by Tryptophan without the side effects caused by SSRIs. It's not a cure (people have to keep taking it) but apparently it's safer for long-term use. It's naturally ocurring in certain foods anyway.


48 posted on 08/13/2006 6:45:52 AM PDT by webstersII
[ Post Reply | Private Reply | To 29 | View Replies]

To: RandallFlagg; 4woodenboats; 68-69TonkinGulfYatchClub; abletruth; Accountable One; Aeronaut; ...
RIP Prayer ping.See post 19 posted on 08/12/2006 4:34:21 AM MDT by RandallFlagg {click the number}

Please post your replies to RandallFlagg


Rest in Peace
 Brother of RandallFlagg

RandallFlagg, My prayers go up for all who now mourn the passing of your brother. Comfort and peace for you all.  

Blessings,
trussell


If you want on/off my prayer ping list, please let me know. All requests happily honored.

49 posted on 08/13/2006 11:08:37 AM PDT by trussell (Work for God...the retirement benefits are eternal!)
[ Post Reply | Private Reply | To 19 | View Replies]

To: RandallFlagg

Randall, you have my deepest sympathy, and I offer my humble prayer for your brother, and everyone he left behind.


50 posted on 08/13/2006 11:17:58 AM PDT by Aeronaut ("Endless repetition is not a coherent argument." —Thomas Sowell)
[ Post Reply | Private Reply | To 19 | View Replies]


Navigation: use the links below to view more comments.
first 1-5051-73 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson