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How a 19th-Century Breakthrough Could Revolutionize COVID-19 Diagnosis
https://www.sciencealert.com ^ | March 3, 2022 | NAEEM RAMZAN, ET AL

Posted on 03/03/2022 7:08:32 AM PST by Red Badger

It sounds simple, but to treat someone you suspect has COVID, you need to confirm they are actually infected with the coronavirus.

In the UK, it is easy to take this for granted – we've had a reliable detection method for diagnosing infected patients widely available since early on in the pandemic. This allowed for people to be treated and cared for promptly, saving lives.

The main technique for identifying whether someone has COVID is called reverse transcription polymerase chain reaction testing – or RT-PCR. This process can tell whether the coronavirus's genetic material is present in a sample taken from a person, usually gathered my swabbing inside the nose or throat.

This testing is normally done in a lab, and the resources needed mean that doing it at scale is a major challenge.

High-income countries have been able to scale up their COVID testing at great cost, but in some low- and middle-income countries – such as Pakistan, Sri Lanka, India and many African countries – health staff haven't been able to carry out large numbers of COVID tests due to a lack of resources. This is a particular problem in remote locations.

On top of this, PCR testing isn't very quick. It typically takes around two hours, and longer if extra time is needed to get the test sample to a suitable lab for testing.

In many cases, confirming whether someone has the virus needs to happen much more rapidly. When someone has severe COVID, treatment really needs to start immediately. Quickly diagnosing the disease is potentially life saving.

So, our team investigated whether a quick and reliable alternative to PCR testing could be provided by using commonly available hospital equipment – namely, the machines available in the radiography department.

COVID shows up in chest scans Chest-imaging techniques – such as computed tomography (CT) or X-ray – can be analyzed by radiologists to search for visual markers of a COVID infection.

Investigations early on in the pandemic found that abnormalities showed up in the chest radiography images of patients with the virus, leading the World Health Organization to recommend using radiography for diagnosing COVID when PCR testing isn't available, especially for severe patients.

But there's a resource bottleneck here, too. Using X-rays and CT scans for diagnosis requires radiologists to carefully decipher the chest images, since COVID's visual pointers can be hard to spot. So, we created an artificial intelligence program to do this instead, to speed up diagnosis and allow radiologists to get on with their jobs.

The program is based on something called a deep convolutional neural network, a type of algorithm typically used to analyze images. Such algorithms can pick out the key features of images and classify those that have similarities and differences.

We began by training and testing a number of different algorithms – some already existing, some that we had created – using a database of around 3,000 chest X-rays. These were a mix of scans from patients with COVID, healthy individuals and people with viral pneumonia.

As we worked, we tweaked the algorithms to make them better at spotting the differences between the X-rays. Over time, we found that one clearly performed better than the others.

We then evaluated this top performer by giving it a completely new set of X-rays that it hadn't seen before, and asked it to determine whether each came from a COVID patient or not. The program got the answer right 98.04 percent of the time.

How could this be used? Following these results, we developed an app that could run the program outside of our lab, so that it could be used in places where it could make a difference. The app doesn't require lots of computer memory or power to run and so can be installed on normal PCs and laptops.

It has been designed in such a way that no additional equipment is needed. Patient X-rays just have to be uploaded to the app via USB or the web, and then the algorithm analyses the image and gives back a result indicating if it is COVID-positive or not.

This app will not replace PCR. But it could be very effective in A&E departments where patients come in with severe illness. It would allow for a chest X-ray to be quickly taken and analyzed, and if the patient is positive, for treatment to start straightaway rather then waiting for lab results.

As well as being beneficial for patients, this could also speed up their passage onto suitable wards elsewhere in the hospital, and so relieve the strain on hard-pressed A&E departments.

The app could also be very effective at diagnosing COVID cases in low-income countries and remote areas where PCR is not readily available. So, as a next step, we're planning to test it out in Pakistan, as part of the EU-funded SAFE RH project, to see what impact it can have in the real world. Naeem Ramzan, Professor of Computing Engineering, University of the West of Scotland; Gabriel Okolo, PhD Candidate, School of Computing, Engineering & Physical Sciences, University of the West of Scotland, and Stamos Katsigiannis, Assistant Professor in Computer Science, Durham University.


TOPICS: Business/Economy; Health/Medicine; History; Society
KEYWORDS: anthonyfauci; covidstooges; ggg; godsgravesglyphs; health; helixmakemineadouble; history; medicine; obamacare; vaccinemandates; xray

1 posted on 03/03/2022 7:08:32 AM PST by Red Badger
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To: ransomnote; ExTexasRedhead; SunkenCiv

Ping!...............


2 posted on 03/03/2022 7:09:01 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

Far more important is that it was a biological warfare virus developed and released by Tony Fauci and the Chinese Communist Party.

People need to go to prison for the rest of their lives.

Everything else is a distraction.


3 posted on 03/03/2022 7:10:19 AM PST by E. Pluribus Unum ("Communism is not love. Communism is a hammer which we use to crush the enemy." ― Mao Zedong [FJB])
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To: Red Badger

If I was in charge here I would delete every mention of god damn Covid. It is over. So over. Let it go!


4 posted on 03/03/2022 7:15:10 AM PST by webheart (I thought I was helping by getting vaccinated but they say I didn’t help at all. )
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To: Red Badger

Pneumonia is a side effect of chronic infection.

This is asinine, considering that no effective treatments are permissible.

It’s demonstrable - scientific, in fact - that providing antivirals at the onset of fever results in DRAMATIC recovery rate, putting this virus below influenza in all classifications governing public health policy.

But we can’t talk about that, now can we?


5 posted on 03/03/2022 7:23:45 AM PST by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: Red Badger
So, the 19th century breakthrough is the x-ray, and then they created an app.

The X-ray I trust, the app I don't because it sounds like a modeling method they use for global warming.

6 posted on 03/03/2022 7:28:29 AM PST by Robert DeLong
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To: Red Badger

It’s getting to be pretty standard stuff these days to train a CNN to “recognize” features from radiographs.


7 posted on 03/03/2022 7:30:31 AM PST by glorgau
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To: Red Badger

Uh!

Don’t the 15-minute swab tests work?


8 posted on 03/03/2022 7:30:59 AM PST by aquila48 (Do not let them make you "care" ! Guilting you is how they control you. )
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To: webheart

It ain’t over till the Fat lady croaks...............


9 posted on 03/03/2022 7:34:46 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: glorgau

CNN?.....................


10 posted on 03/03/2022 7:35:26 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

Interesting, but they don’t explain how their testing could distinguish from another respiratory virus like influenza. From what I hear the PCR tests were deliberately skewed to also pick up flu and RSV.


11 posted on 03/03/2022 7:45:28 AM PST by Missouri gal
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To: Red Badger

By the time you have Covid pneumonia, it is too late. Treatment should begin earlier to prevent that.


12 posted on 03/03/2022 7:53:06 AM PST by FarCenter
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To: Red Badger

The covid tests are a fraud. They didn’t even use covid to form them. They trigger on the common cold.


13 posted on 03/03/2022 8:02:14 AM PST by Revel
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To: Red Badger

Testing for those with no symptoms a waste of time and resources IMHO. Better to focus on prevention and early treatment. For this to happen requires fauci on a gallows at GTMO.


14 posted on 03/03/2022 8:20:51 AM PST by Chauncey Gardiner
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To: Red Badger

All we have to do is time-travel back to the 19th Century.

Some of us are already there!


15 posted on 03/03/2022 8:26:08 AM PST by SaxxonWoods (The only way to secure your own future is to create it yourself.)
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To: SaxxonWoods

Cases Cases Cases, that is why they use a test that doesn’t work, especially at cycles that they test at. You cannot get the data sets for what cycle they are testing at, it is a secret that comes out only in drabs and the info is then called a lie. In WA state, they used PCR 35-45 by all accounts. If the PTB wanted more cases for policy pushes, they just moved the testing to catch month old colds, and flu.


16 posted on 03/03/2022 1:42:51 PM PST by Glad2bnuts ((“If there are no absolutes by which to judge society, then society is absolute.” Francis Schaeffer,)
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To: Red Badger; StayAt HomeMother; Ernest_at_the_Beach; 1ofmanyfree; 21twelve; 24Karet; ...
Thanks Red Badger.

17 posted on 03/03/2022 10:13:33 PM PST by SunkenCiv (Imagine an imaginary menagerie manager imagining managing an imaginary menagerie.)
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