Ever notice the women walking around collecting money for the Mothers March of Dimes? Ever notice they're always collecting money for research to PREVENT mutations, and not to CAUSE them? Basically, in the real world, mutations all have names, like Downs syndrome, Tay-Sachs disease, Phoco-Loci, cri-du-chat syndrome etc. etc.
Science has now quantitated that a genetic mutation of as little as 1 billionth (0.0000001%) of an animal's genome is relentlessly fatal.The genetic difference between human and his nearest relative, the chimpanzee, is at least 1.6% Calculated out that is a gap of at least 48 million nucleotide differences that must be bridged by random changes. And a random change of only 3 nucleotides is fatal to an animal. Geneticist Barney Maddox, 1992 )