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Study offers first picture of effects of SARS
CTV.ca ^ | May 28, 2003 | CTV.ca News Staff

Posted on 05/29/2003 12:27:11 AM PDT by Judith Anne

A new study, released early by the Canadian Medical Association Journal, shows that the toll SARS takes on health care workers is more profound than many doctors expected.

The research is based on 14 Toronto-area health care workers, many of them nurses, who developed SARS in late March. They suffered from fatigue, pneumonia, and in some cases severe life threatening anemia.

Of the 14 studied, 13 have still not returned to work, weeks after they were released from hospital. And many may be suffering from Post Traumatic Stress Disorder, similar to soldiers returning from war.

The study is the most detailed clinical analysis of what happens to people hit by the new and mysterious illness. It was released on the CMAJ website about a month before the paper's appearance in the print version of CMAJ.

CMAJ STUDY:Clinical course and management of SARS in health care workers in Toronto

The study found that the disease usually developed within four four days of exposure. It often caused full pneumonia in less than three days. Patients remained in hospital for a mean of 14 days.

Many suffered temporary heart problems and long term breathing problems that still persist up to eight weeks later, leaving them breathless and exhausted.

"These are healthy health care workers. The mean age was 42, so they are not old people," explains Dr. Monica Avendano, one of the authors of the study.

Another key finding from the study is the high number of patients who developed severe hemolytic anemia. Some required lifesaving blood transfusions.

The doctors aren't certain whether the anemia is a results of the SARS itself or a complication of treatment, possibly associated with the use of ribavirin, an anti-viral drug doctors were testing on patients at the time. The drug is no longer in use.

Most striking of all the effects were the deep psychological and emotional problem, including insomnia and nightmares. Most of the patients expressed feelings of fear, depression and anxiety at the time of the acute illness.

Pat Tamilin, one of those studied, was "sicker than I've ever been ... it's worse than any pneumonia." And she's concerned about going back to work. "I don't want to be the first health care worker to get SARS twice," she said.

In addition, many of those in the study expressed frustration at being in isolation and without contact with family and loved ones. This was particularly the case for those patients with young children, and especially the two patients whose children developed SARS.

"We are convinced that they have some sort of post traumatic stress disorder," says Dr. Avendano

There was one bright bit of news. The study found that the 14 subjects had contact with 33 family members. Of them, only two developed SARS, and both were mild cases. But disturbingly, one didn't develop symptoms until 12 days after the last contact with the family member -- suggesting that the 10-day quarantine period currently recommended may not be long enough.

The conclusion of the doctors is that SARS is a fast moving disease that if survived, results in a long slow recovery once the acute phase of the disease ends -- as long as two months.

Only one of the 14 subjects has returned to work. If that trend continues and more health care workers are similarly affected in this second wave of cases, it could seriously deplete the health care system.

"The disease continues to linger, the inflammatory process stays for a long time, and we don't know how long," says Dr. Peter Derkach, another of the study's authors.

That's why researchers plan to follow these health care workers for some time to come, to get the clearest picture of the long-term effects of the disease.


TOPICS: Breaking News; Canada; Culture/Society
KEYWORDS: sars
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To: per loin
Thanks for those additional figures. It would be nice if we could keep this from spreading rampant through the US, but it may be only a matter of time until it does.
41 posted on 05/29/2003 2:27:34 AM PDT by DoughtyOne
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To: DoughtyOne
If it will make you feel better, I'll add insult to injury. ;-D

But it isn't necessary--really. Not everyone would be as nice about it as you have been. There are a few who still think we're goofy, and I suspect they'll be the first ones screaming if and when there is a serious US outbreak this fall (as I think there will be).
42 posted on 05/29/2003 2:29:25 AM PDT by Judith Anne
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To: Judith Anne
So, if China has stopped reporting any new cases, and now a Russian has a confirmed case near the China border, and Taiwan is fudging numbers, and Canada if fudging numbers...

Probably means it's out of control, that's my guess, and nobody's going to report numbers any more.

You are most likely correct. The best we can do is watch it and learn all we can from what little they will tell us.

I think cheating and fudging are universal. Take Germany for example, rarely if ever do they report a 'probable' case until AFTER s/he recovers.

And the U.S. still has 32 VERY sick patients it seems, as that number is refusing to come down. It's been considerably longer than the worldwide 'average number of days till recovery'. Several of them must be near death and kept alive by extreme measures.

And I don't have much confidence in that Kaiser Permanente SARS situation either. That organization was the WORST!!!

43 posted on 05/29/2003 2:31:20 AM PDT by Future Useless Eater (Freedom_Loving_Engineer)
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To: Judith Anne
To be honest, most hospitals in the US have been downsizing. I know of one local hospital that used to be rated for 452 beds that is now approaching capacity with 325 patients. Rooms have been converted into offices etc, with reverse airflow rooms not being used to the degree they used to be. I'm not even sure if the three they had are still opperable.

My region's health care facilities have been savaged by having to provide services with inadequate reimbursements. Now when the system is going to be needed, it's not going to be there to the degree it should be.
44 posted on 05/29/2003 2:32:23 AM PDT by DoughtyOne
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To: DoughtyOne
No problem D.O. ... Welcome to the discussion group.
45 posted on 05/29/2003 2:33:33 AM PDT by Future Useless Eater (Freedom_Loving_Engineer)
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To: DoughtyOne
Happy to supply them, and to see someone quickly change their opinions when others present facts.
46 posted on 05/29/2003 2:34:45 AM PDT by per loin
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To: DoughtyOne
How well I know! You are absolutely right about the downsizing and capacity.

I'm guessing that there will be SARS facilities set up separate from regular hospitals (though I don't think it will keep SARS out of the hospitals). Another sobering read is the disinfection procedure required for ambulances, it will take longer than transporting the patients...

If there are outbreaks in the US this fall during the flu season, as many health authorities consider, the ability of hospitals to deliver critical care will be unmasked. The two small rural hospitals where I work would be overwhelmed in short order, with regular patients along with escalating numbers of SARS victims...
47 posted on 05/29/2003 2:37:57 AM PDT by Judith Anne
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To: FL_engineer
Thank you. My wife and I are under the Kaiser Permanente plan now. I've never been a big fan of the organization, but in some ways they have been helpful to me. I have to take anti-coagulation therapy, and their pharmacy tracks this. For the first time in about seven years, they have me dosing properly on a daily basis. I wasn't doing so under my old provider.
48 posted on 05/29/2003 2:38:09 AM PDT by DoughtyOne
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To: DoughtyOne
Every organization has strengths and weaknesses. Glad to hear you are doing well...my concern is that SARS will expose all the weaknesses.
49 posted on 05/29/2003 2:41:58 AM PDT by Judith Anne
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To: Judith Anne
Let's cross-link:

-SARS ( atypical pneumonia )- a partial archive --

50 posted on 05/29/2003 2:44:00 AM PDT by backhoe
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To: backhoe
Yes, lets! And thank you, profoundly.
51 posted on 05/29/2003 2:47:04 AM PDT by Judith Anne
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To: Judith Anne
If SARS does break out in the US this fall, I agree that it will expose a myriad of evils. We've played fast and lose with our health care system. Perhaps this is what it will take for us to take health care seriously.

Hillary's, and other people's idea that medical centers and other health providers could simple eat the costs of health care, were ill advised. No business can operate at a loss or a very slim margin forever.

Thanks for the discussion.
52 posted on 05/29/2003 2:47:22 AM PDT by DoughtyOne
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To: DoughtyOne
You're welcome.
53 posted on 05/29/2003 2:54:03 AM PDT by Judith Anne
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To: Judith Anne
...my concern is that SARS will expose all the weaknesses.

A reasonable cocern, but I would stipulate that it is nearly impossible to maintain a position that would be able to absorb the effects of any pandemic. The O&M costs would be staggering. I am not saying that we shouldn't take reasonable steps which would allow us to move to a full up defensive posture more rapidly if this SARS turns out to be more deadly in the second round as was the Spanish Lady.

I have followed all of the SARS threads (or most of them). I dropped off posting early on in the SARS discussions because the uninformed naysayers were getting on my nerves. I note that you have hung in there from nearly the beginning. Kudos to you.

The latest round of speculation in the press is that we have paid too much attention to SARS to the detriment of more menacing problems, the latest being the West Nile problem. I guess some folks think everything is a zero sum game. The concept of parrallel processsing and dynamic response is totally foreign to their pea pickin' intellects.

54 posted on 05/29/2003 2:54:21 AM PDT by Movemout
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To: Movemout
Thoughtful remarks, and you're right. As the system is now, there is no way to maintain a defensive posture all the time. I don't know what measures would enable us to ratchet up in case of outbreak(s). I am concerned about being caught with my (N95) mask off and my scrubs down, so to speak.

One of the scenarios I imagined at the beginning of these threads was a person with a broken bone or appendicitis, coming down with SARS all unsuspected, while in the hospital for the more ordinary illness.

Now I see that in Canada, it's happened, the man died, healthcare workers were exposed and sickened, and other patients infected. Not reassuring. And some called us panic-mongers for our speculation...
55 posted on 05/29/2003 3:02:53 AM PDT by Judith Anne
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To: Judith Anne
I don't know what measures would enable us to ratchet up in case of outbreak(s).

I'm not in the medical profession so I can't say for certain. I would note that after 9/11 that the feds started stockpiling bio/chemical/medical gear and then palletized the material so as to be able to transport it to affected sites by military cargo planes. That wouldn't be out of the question. Surveying capabilities, by region, to deal with a SARS pandemic is doable. This would at least identify where investment in the infrastructure is critical. Even without SARS rearing its ugly head, the statistical occurence of pandemics suggests that we are overdue and if SARS goes away then what other bug is around the corner?

Given the role of viruses in nature, and given the total biomass available on the planet for a mutated virus to exploit, it is inevitable that we will be dealing with a massive problem, probably within most of our lifetimes.

56 posted on 05/29/2003 3:18:06 AM PDT by Movemout
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To: Movemout
The surveys are probably being done, and thanks for that information...I'd forgotten and frankly, it's nice to be reminded.


57 posted on 05/29/2003 3:26:16 AM PDT by Judith Anne
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To: Judith Anne
Question:

Do the majority of SARS patients require ventilators and, if so, just masks or with trach tubes?

The Fall/Winter could see a return of SARS in pandemic proportions and I certainly hope that the supply of ventilators will be sufficient for such a situation.

It appears that SARS outbreaks in areas without sophisticated medical device availability would result in a vastly greater mortality rate than that experience so far!

58 posted on 05/29/2003 3:32:13 AM PDT by ExSES
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To: ExSES
About 20% require mechanical ventilation, is what I recall. I could be mistaken, and anyone who has better information, please correct me here.
59 posted on 05/29/2003 3:37:10 AM PDT by Judith Anne
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To: Judith Anne; All
First thing I did this morning was check out this thread, and I am impressed! This is what FR was like in the good old days, when we had reasonable discussions with one another, seeking good information, learning from one another!

To see the open minds here, even if coming from different points of view, checking their own preconceptions, then revising these in light of newer information, gives me hope for the world!

By the way, Judith Anne... We have found that we get better medical care from our small rural hospital then from the city hospital nearby. We are about half way out in the country between the two. The rural hospital responds more quickly to true emergencies, and has excellent connections to a much larger city hospital about 90 minutes away be ambulance. Less by helicopter!

Of course, then we are left with the unending battle with the insurance company about the bill. I am guessing that if there is a SARS outbreak, the rural hospital will be a better bet for treatment, but that is probably silly, as probably all the normal rules will go out the window.
60 posted on 05/29/2003 3:56:32 AM PDT by jacquej
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