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West Nile may be mutating, expert says -- 'Something peculiar' about 4 U.S. deaths
National Post ^ | August 3, 2002 | Brad Evenson

Posted on 08/03/2002 8:00:01 AM PDT by Clive

OTTAWA - Canadian health authorities are worried an outbreak of West Nile virus infection in Louisiana, which has killed four of 58 infected people, could mean the mosquito-borne illness is changing the way it spreads.

"Something seems peculiar about Louisiana with such a large number of human cases," said Harvey Artsob, head of zoonotic diseases at Health Canada.

"It's important for us to understand why, so that all our messages of reassurance in other parts of North America still hold. What's changed in Louisiana?"

As Canadians head to summer cottages this weekend, the official government message remains that West Nile virus is rare.

While some dead birds in Quebec, Ontario and Manitoba carried the virus, no human cases have been reported.

But Dr. Artsob, the nation's foremost expert on West Nile, suspects some Canadians have been exposed to the virus, which has killed 22 people since arriving in North America in 1999.

"I think there have been people who probably were infected last year, [but] I can't guarantee it," he said yesterday, adding the government contemplated testing thousands of blood samples to search for presence of the virus.

In Manitoba, health officials are still awaiting test results of 14 individuals. Thirty people in the province were tested after they displayed symptoms similar to West Nile, but 16 have been cleared so far. Test results are not expected until next week.

This week, the Ontario government announced plans to spend $9-million to kill mosquitoes carrying the virus. Health officials urged people to remove places where mosquitoes can breed, such as standing water in birdbaths, repair screens in doors and windows and use insect repellent.

The Louisiana outbreak, which yesterday prompted officials to declare a state of emergency, is expected to surpass the outbreak in New York three years ago, which infected 62 people and killed seven.

"There is no sign that this is going to go down. This is only the beginning," said Raoult Ratard, an epidemiologist with the Louisiana Department of Health and Hospitals. "We'll probably end up with the worst outbreak."

First isolated in 1937, West Nile virus was common in Africa and Asia but not seen in North America until 1999. Experts believe this strain arrived from the Middle East. Its genetic material is "almost identical to that of a [viral] isolate taken from a dead goose in Israel in 1988," Dr. Artsob said.

Dr. Artsob said human cases are typically seen about 30 days after dead birds are found. The birds become infected after being bitten by mosquitoes that feed only on birds. The virus multiplies in the birds' bloodstreams and is then carried to humans by other mosquito species that bite both birds and humans, bridging the species gap. This cycle means outbreaks are concentrated in late August and early September.

Public health officials across the United States and Canada are concerned because the disease has erupted so early in the summer in Louisiana. "Has it gotten into a broader range of mosquito species than up in the Northeast?" Dr. Artsob wondered.

Most people who contract West Nile suffer nothing more than headaches and flu-like symptoms, but the elderly, the chronically ill and others with weak immune systems can develop fatal encephalitis, or brain inflammation.

Experts say for every one person who gets seriously ill, there are as many as 300 infected with the virus who suffer no major symptoms. Elderly people are the most susceptible to illness because their immune systems are weakest.

"Unfortunately, there is no directed therapy to this virus," said Marc Desjardins, a clinical microbiologist at Ottawa General Hospital.

"People have been trying various anti-viral agents, but there doesn't appear to be any kind of success with those. So largely, therapy revolves around supportive care. There is nothing that will specifically target the West Nile virus."

Dr. Desjardins said Ontario's plan to control larval and adult mosquitoes is wise, considering how easily once-exotic diseases can be spread via airline travel. "We can go to Africa today and then be home tomorrow from these hot zones, as they're called," he says. "So any kind of public health intervention is worth the money."

Some scientists say the West Nile virus is growing more dangerous with time. Decades ago, the strain that spread through Africa and the Middle East caused little more than a fever. But recent strains seem to cause encephalitis with more regularity, particularly in North America.

Dr. Desjardins says this may be because the virus is a "foreign" invader. "You have to keep in mind that where this virus is traditionally seen, in North Africa and the Mediterranean, there's a certain amount of exposure to it and people have a level of immunity.

"So in these populations, the virus may not present the same way as when it's introduced into an entirely 'naive' population like in North America.

"On a clinical basis, there certainly are some major differences between what we're seeing [here] and the patients that you traditionally see in the African subcontinent."


TOPICS: Culture/Society; Front Page News; Miscellaneous
KEYWORDS: westnilevirus; wnv
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To: Clive
Dr. Desjardins says this may be because the virus is a "foreign" invader. "

I'd definitely wager my money on the bet that a "foreign" invader introduced this to the United States.

21 posted on 08/03/2002 11:10:47 AM PDT by dubyagee
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To: dubyagee
As a New Jersey resident who has been seeing this up close since '99, and why it suddenly appeared, this has been my thought since the beginning. Whether it was a "test case" or they know that it spreads, mutates or whatever, it is very odd that it appeared out of "nowhere" in '99.

But again, the media will not pick up on this and remember there was no terrorism here according to the media back in the 90s. (sarc)
22 posted on 08/03/2002 11:28:30 AM PDT by Captain Culpepper
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To: Centurion2000; Dave in Eugene of all places; Dick Vomer
DDT is safe: just ask the professor who ate it for 40 ...
... DDT is safe: just ask the professor who ate it for 40 years Culture/Society Editorial
Editorial Source: The Telegraph (UK) Published: 07/19/2001 Author ...

Banning DDT to control global population [Free Republic]
... Banning DDT to control global population Government Front Page News Source: ECO-LOGIC
-----ON-LINE---- Published: Jan/15/2001 Author: Paul K. Driessen Posted ...

Bring back DDT [Free Republic]
... Bring back DDT Culture/Society Editorial Source: Jewish World Review Published: April
24 2001 Author: Betsy Hart Posted on 04/24/2001 06:02:38 PDT by SJackson. ...

Audubon's Fly-by-Night Pesticide Campaign [Free Republic]
... 30 years after its successful — but untruthful — campaign against the insecticide
DDT, the Audubon Society is targeting lawn chemicals used to control grubs ...

CENTER NAMES TEN TOP SCARE CAMPAIGNS THREATENING [Free ...
... The Banning of DDT is first on the list of the Center’s Chicken Little Awards, largely
due to the alarmist, false writings of Rachel Carson. "The sole purpose ...

Killing Mosquitoes Or Killing Humans? [Free Republic]
... long since been proven wrong. By way of just one example, she claimed that DDT spraying
could wipe out the US robin population. Instead, it actually increased ...

Billions Served (benefits of biotechnology the Greens won't ...
... Of course. This is a negative effect. We always have this. Take the case of DDT.
When it was banned here in the US and the European countries, I testified ...

Scams, Scalawags, and an all-too-gullible Public...famous frauds sold to America

Bring Back DDT, and Save Lives from the Wall Street Journal, July 28, 2000.

Bring back DDT, Jewish World Review, April 24, 2001.

23 posted on 08/03/2002 11:33:05 AM PDT by backhoe
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To: backhoe
4 Confirmed Dead in La.
24 posted on 08/03/2002 5:35:13 PM PDT by TaRaRaBoomDeAyGoreLostToday!
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To: backhoe
CDC Home Page; On The West Nile Virus
25 posted on 08/03/2002 5:37:38 PM PDT by TaRaRaBoomDeAyGoreLostToday!
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To: TaRaRaBoomDeAyGoreLostToday!
I'll use that link- thanks! Gotta run--
26 posted on 08/03/2002 5:41:30 PM PDT by backhoe
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To: Dave S
OK, how about 10 years? (HIV incubation time lag)...
27 posted on 08/03/2002 10:51:39 PM PDT by null and void
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To: backhoe

Nick Leggio finds a dead blue jay in his New Orleans yard on Saturday, as he waits for the city's pest control officials to pick up the bird to test for West Nile virus. Blue jays are among the birds most often found to harbor the virus.


28 posted on 08/04/2002 6:38:42 AM PDT by TaRaRaBoomDeAyGoreLostToday!
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To: backhoe
VECTORS AND SYMPTOMS

Most people who contract West Nile suffer nothing more than headaches and flu-like symptoms, but the elderly, chronically ill and those with weak immune systems can develop fatal encephalitis and meningitis when infected. At least 31 states, stretching from Massachusetts to Texas, and the District of Columbia have reported some West Nile activity in 2002, according to the CDC’s latest update on the virus.

29 posted on 08/04/2002 6:41:01 AM PDT by TaRaRaBoomDeAyGoreLostToday!
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To: Mitchell
Thanks for the heads up!
30 posted on 08/04/2002 3:22:02 PM PDT by Alamo-Girl
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To: backhoe
bump
31 posted on 08/06/2002 6:28:41 PM PDT by TaRaRaBoomDeAyGoreLostToday!
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To: aristeides; dubyagee
The foreign invader is emigrating from Israel. I guess these mosquitoes aren't Zionists.

West Nile-Israeli Strain

32 posted on 08/07/2002 5:07:40 AM PDT by rubbertramp
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To: Clive
so we are to understand that WN can species hop from infected bird to skeeter to human - but HIV wont ? - I dont get it
33 posted on 08/07/2002 5:20:58 AM PDT by Revelation 911
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To: TaRaRaBoomDeAyGoreLostToday!
Nick Leggio finds a dead blue jay in his New Orleans yard on Saturday, as he waits for the city's pest control officials to pick up the bird to test for West Nile virus. Blue jays are among the birds most often found to harbor the virus.

Now wait a minute - Isnt posession of a migratory songbird (or its feathers) illegal ? LOL

34 posted on 08/07/2002 5:25:30 AM PDT by Revelation 911
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To: TaRaRaBoomDeAyGoreLostToday!
Nick Leggio finds a dead blue jay in his New Orleans yard on Saturday, as he waits for the city's pest control officials to pick up the bird to test for West Nile virus. Blue jays are among the birds most often found to harbor the virus.

Now wait a minute - Isnt posession of a migratory songbird (or its feathers) illegal ? LOL

35 posted on 08/07/2002 5:25:44 AM PDT by Revelation 911
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To: Revelation 911
oops
36 posted on 08/07/2002 5:27:13 AM PDT by Revelation 911
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To: rubbertramp
The third way West Nile may have entered the U.S. is through a virus-carrying mosquito itself.

Perhaps some peace-loving, Islamic Palestinian mistakenly brought a few when he came to visit The Great Satan.

37 posted on 08/07/2002 6:47:17 AM PDT by dubyagee
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To: null and void
A quarantine of travellers would do nothing. The vector for this epidemic is the mosquito. One thing that would help would be bring back the use of DDT immediately.
38 posted on 08/07/2002 6:51:40 AM PDT by fogarty
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To: Revelation 911
WNV and HIV are different. HIV is killed in mosquito saliva so it needs to be spread in blood (I think I read this somewhere.) Mosquitos do not inject blood generally, just saliva. WNV (and the malaria parasite) are transmitted by the saliva. (You may want to look in the medical literature to verify this. I'm just remembering from way back.)

The epidemiology of HIV is not consistent with mosquito-borne diseases. The children do not get HIV. HIV infection is consistent with the epidemiology of other sexually transmitted diseases.
39 posted on 08/07/2002 7:18:44 AM PDT by Doctor Stochastic
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To: fogarty
Well duh! West Nile is here already. I'm talking about future diseases. My point being that we CAN'T keep them out, unless we are willing to shutdown international trade.

Millions, perhaps billions would starve if we did this.

We're just going to have to get better at treating and containing. Or we could just all die...

40 posted on 08/07/2002 8:48:12 AM PDT by null and void
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