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Most Significant Scientific Retraction Ever? ( Alzheimer's Disease)
https://hotair.com/david-strom/2024/06/07/most-significant-scientific-retraction-ever-n3789789 ^ | 6/8/2024 | david strom

Posted on 06/09/2024 7:17:58 AM PDT by bitt

It may or may not be the most significant retraction of a scientific paper ever, but it certainly is in the ballpark.

The paper helped create and sustain the theory that amyloid protein buildups caused the symptoms of Alzheimer's Disease and was one of a number of apparently fraudulent papers written by Sylvain Lesné, a professor at the University of Minnesota, Twin Cities.

All the paper's authors agreed to retract, save Lesné, who has been under investigation for manipulating data.

"Authors of a landmark Alzheimer’s disease research paper published in Nature in 2006 have agreed to retract the study in response to allegations of image manipulation. University of Minnesota (UMN) Twin Cities neuroscientist Karen Ashe, the paper’s senior author, acknowledged in a post on the journal discussion site PubPeer that the paper contains doctored images. The study has been cited nearly 2500 times, and would be the most cited paper ever to be retracted, according to Retraction Watch data.

“Although I had no knowledge of any image manipulations in the published paper until it was brought to my attention two years ago,” Ashe wrote on PubPeer, “it is clear that several of the figures in Lesné et al. (2006) have been manipulated … for which I as the senior and corresponding author take ultimate responsibility.”

After initially arguing the paper’s problems could be addressed with a correction, Ashe said in another post last week that all of the authors had agreed to a retraction—with the exception of its first author, UMN neuro-
scientist Sylvain Lesné, a protégé of Ashe’s who was the focus of a 2022 investigation by Science. A Nature spokesperson would not comment on the journal’s plans."

(Excerpt) Read more at hotair.com ...


TOPICS:
KEYWORDS: alzheimers; alzheimersdisease; amyloidprotein; davidstrom; fraud; karenashe; minnesota; pubpeer; retractionwatch; sylvainlesne; uofminnesota
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1 posted on 06/09/2024 7:17:58 AM PDT by bitt
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To: null and void; aragorn; EnigmaticAnomaly; kalee; Kale; AZ .44 MAG; Baynative; bgill; bitt; ...

https://www.science.org/content/article/researchers-plan-retract-landmark-alzheimers-paper-containing-doctored-images


2 posted on 06/09/2024 7:18:31 AM PDT by bitt (<img src=' 'width=30%>)
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To: bitt

This is why we question science


3 posted on 06/09/2024 7:20:32 AM PDT by Fire137 (A man once said to me the whole world is bullshit- he was right. )
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To: bitt

All good and fine, but will they get to REAL CAUSE of Alzheimer’s, which is suppressed cholesterol levels due to the mass use of Statins?


4 posted on 06/09/2024 7:24:26 AM PDT by BobL (Yes, it's sarcasm, but use your brain when you vote, not your emotions)
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To: bitt

I always thought the Polio vax was a “good” vax, effective, etc.

A couple of years ago I read “The Moth in the Iron Lung” by Forest Maready who makes a strong case that the cause of Polio was DDT/pesticides in the food system, and when DDT was banned before the vax was available the Polio rates fell. There is also a very good, controversial book, “The River,” that argues that the Belgian Congo oral polio vaccines used chimps, not green monkeys and that their tissue gave rise to SIV that jumped to humans.


5 posted on 06/09/2024 7:26:31 AM PDT by LS ("Castles made of sand, fall in the sea . . . eventually." Jimi Hendrix)
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To: Fire137
”This is why we question science”

This is why we question scientists. There is nothing wrong with science.

Doctoring images is not science; it is fraud.

6 posted on 06/09/2024 7:27:23 AM PDT by William Tell
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To: LS

“… the cause of Polio was DDT/pesticides…”

No. The cause of polio is the polio virus.


7 posted on 06/09/2024 7:29:02 AM PDT by VanShuyten ("...that all the donkeys were dead. I know nothing as to the fate of the less valuable animals.)
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To: bitt

https://en.wikipedia.org/wiki/Sylvain_Lesn%C3%A9


the victim?


8 posted on 06/09/2024 7:29:18 AM PDT by PeterPrinciple (Thinking Caps are no longer being issued but there must be a warehouse full of them somewhere.)
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To: bitt; All

Thanks to every poster. Life/health BUMP


9 posted on 06/09/2024 7:29:26 AM PDT by PGalt (Past Peak Civilization?)
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To: bitt
Are these people saying that any modified image is not publishable?

I modify images all the time, for the purpose of correcting lighting problems when they were photographed. I deliberately under-expose digital images for that purpose, because reflected glare that goes to white is not correctable. My goal in doing that editorial work is to portray the image as I saw it as accurately as possible. How is such a problem?

Hence, for the article to say "modified" as if it were bad without discussing what those specific modifications were is beyond confusing.

10 posted on 06/09/2024 7:32:15 AM PDT by Carry_Okie (The tree of liberty needs a rope.)
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To: bitt

Follow the sciiiiience.


11 posted on 06/09/2024 7:34:01 AM PDT by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: bitt

Beta amyloid might not be the ultimate cause of Alzheimer’s, but it is present in nearly every case, so the connection is there, if not clear.

“ The paper helped create and sustain the theory that amyloid protein buildups caused the symptoms of Alzheimer’s Disease…”

That’s untrue. The amyloid hypothesis for Alzheimer’s has been around since the 1970s. There is ample evidence that the build up of amyloid in neurons leads to their death.


12 posted on 06/09/2024 7:35:18 AM PDT by VanShuyten ("...that all the donkeys were dead. I know nothing as to the fate of the less valuable animals.)
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To: bitt

Double blinds - replication - peer review - disclosure of data - funding not contingent upon results - Non-Fauci direction -

What is your scientific base today?

What consequence for scientific fraudsters?


13 posted on 06/09/2024 7:36:29 AM PDT by LachlanMinnesota
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To: LS

DDT was banned in 1972

The Polio vaccine was 20 years before that in the early 1950s.


14 posted on 06/09/2024 7:40:46 AM PDT by John Milner (Marching for Peace is like breathing for food.)
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To: bitt

Wow! Sad that some folks are so desperate to be the ones who solve a disease problem, or discover th3 cause or whatever, resort to lying and manipulation to gain attention.

Alzheimers is a terrible terrible disease, and lots of people try to play on the emotions and desperation of sufferers and their families- youtube is chockerblock full of promises and wild claims about either spring or helping peop.e with the condition

So many self proclaimed “naturalists” (or herbalists) making outlandish claims, usually saying things like “medical doctors don’t want you to onow that alzheimers can be controlled” or some such claim.


15 posted on 06/09/2024 7:43:54 AM PDT by Bob434
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To: bitt

Old news this came out at least 2 years ago on the phony data manipulation.


16 posted on 06/09/2024 7:44:44 AM PDT by Captain Peter Blood
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To: Captain Peter Blood

Maybe, but glad it was posed here on fr today- I hadn’t seen it before, and was under the impression that amyloid buildup was what brought on alzheimers from many articles I’ve read on the issue-


17 posted on 06/09/2024 7:47:54 AM PDT by Bob434
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To: bitt

Shocked, I tell ya.

/s


18 posted on 06/09/2024 7:48:02 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: Fire137

This is why science is never ‘settled’ (just one of many dog whistles for fraud).


19 posted on 06/09/2024 7:49:18 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: BobL

I disagree.

But not only am I NOT going down that bunny hole this morning, we will have to wait and see how many decades it takes for the corruption of medical research to subside (that’s sarcasm; it never will).

Simply: If you don’t want to be susceptible to such disease, simply follow advice for reducing inflammation, and that includes withdrawing from much of the activities the establishment promotes to impose impaired health and make you dependent upon them.


20 posted on 06/09/2024 7:55:37 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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