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What to know about the India coronavirus variant causing worries
Washington Examiner ^ | April 24, 2021 | David Hogberg

Posted on 04/25/2021 11:58:15 AM PDT by BeauBo

A new variant of the coronavirus has developed in India, one that is making public health officials worried because it may be causing the country's terrible outbreak and could reduce the efficacy of available vaccines.

The India variant, known as B.1.617 and first identified in October, has been dubbed the “double mutant” variant because it contains two mutations of interest, E484Q and L452R. These are mutations on the spike protein, the part of the virus that attaches to a cell.

"Having two of these mutations which have been seen in other variants around the world are concerning, because there's a similarity in these mutations that confer increased transmissibility, and some of these mutations also result in reduced neutralization, which may have an impact on our countermeasures, including the vaccines," said Maria Van Kerkhove.

E484Q and L452R are known as escape mutations. These types of mutations make it easier for the spike proteins on the virus to evade the antibodies elicited by vaccines and invade cells in the body. Recent research in the journal Cell Host & Microbe found that E484Q was able to evade antibodies in convalescent plasma. An article in Cell recently found that variants containing L452R became more resistant to neutralizing antibodies.

Those attributes raise the fear that a person who's been vaccinated might still be able to carry enough of the mutated virus to infect others, including people who have not been inoculated or have been but have weakened immune systems...

Still, people who have been vaccinated and are infected by a coronavirus mutation are not likely to develop severe COVID-19 or die. Vaccines also elicit a response from another part of the immune system known as T-cells that attack cells infected with a virus... T-cells are able to recognize mutated forms of the coronavirus.

(Excerpt) Read more at washingtonexaminer.com ...


TOPICS: Business/Economy; Culture/Society; Foreign Affairs; News/Current Events
KEYWORDS: b1617; billybear; chinavirus; covid; doublemutant; fearpers; fearthevariant; india; info; omganothervariant; spikeprotein; tellusitsraining; wereallgonnadiesir
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To: setter
You still haven't read what I wrote. If you are vaccinated and get COVID you are just as likely to be hospitalized and die as a non-vaccinated person who gets COVID.
81 posted on 04/25/2021 4:30:56 PM PDT by palmer (Democracy Dies Six Ways from Sunday)
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To: entropy12

“In terms lethality, covid-19 is not much more than influenza.”

Covid is 3.5 -5 times more lethal than influenza.


82 posted on 04/25/2021 4:31:11 PM PDT by setter
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To: mrsmith

The cytokine storm is a hyperinflammatory state, due to excessive immune response.

It was a serious problem with earlier attempts to make coronavirus vaccines out of whole virus (in response to the SARS outbreak, over a decade ago). That technical approach was abandoned as inherently unsafe.

None of the authorized vaccines (none of which use whole coronavirus) have shown that risk - and it was specifically checked for in testing.


83 posted on 04/25/2021 4:31:12 PM PDT by BeauBo
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To: grey_whiskers

Moderna’s name comes from Mode (i.e. method) RNA, not derived from the word modern.


84 posted on 04/25/2021 4:33:38 PM PDT by BeauBo
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To: entropy12
Shaking my head.

You VAX-trolls.

I might've believed you except I saw a thread where the usual suspects were laughing about the flat earth anti vaxxers.

There's potentially a lot more to it; but there are several different ways (each totally disjoint) where there might be a lot more to it.

And with all the principals lying through their teeth, consistently, since this thing started, going with the null hypothesis towards any claim by ANYONE in big pharma, or the government, is the way to maximize safety.

This started with China, and supposed bootleg clips of people falling down dead in the middle of the street, of province-wide roadblocks trying to keep people in whatever province Wuhan is in.

The Democrats called Trump ray-ciss for shutting down air travel from China (largely); while themselves insisting people gather in large groups in Chinatown, New Year's whatever.

Then I think it was in Oregon or Washington State, the first cluster in nursing homes.

Trump mobilized the military and built sequestered COVID hospitals in convention centers and sent dedicated US navy medical ships to NY and (I think) San Diego.

The Dem governors did NOTHING except force the infected into nursing homes, and insist first that we didn't need masks, save them for the doctors; then insisted OMG everyone must mask and separate ("two weeks to slow the spread.")

It's been over a year. Wuhan has opened up, so has China.

The Third World didn't have the slate-wiping mass casualties; neither did India, nor Japan, nor Singapore.

But somehow, OMG the entire US economy must be shut down FOREVER over it.

And then the "vaccines."

Trump (backed up by clinical evidence by a number of MDs treating patients) suggested various things from Ivermectin, HCQ/Zinc, monoclonal antibodies.

The press's response was to lie and said he told people to drink bleach or fishbowl cleaner.

I didn't hear a single one of you trolls uttering even a single syllable in defense of Trump.

And of course the coof was the excuse for the fraud which resulted in the stolen election.

You keep dancing back and forth (as a group). "OMG vaccinate, you dumb hicks, why do you want to die?" and then "Oh well, the virus isn't THAT bad, so the vaccine isn't that bad, because *SCIENCE*!"

The problem is

a) the jab was rushed through unnecessarily; we now know from a year's experience, most of those who die or have (at least in the short term) suffered debilitating injuries from the coof, had other issues: obesity, high-blood pressure, autoimmune disorders.

b) the jab was rushed through without proper testing. A description of the animal tests in NEJM talked of a trial group of 16 primates. 8 in placebo, 8 in control. Not enough for meaningful statistics. And no long term observation. And I've read the particular primate used, is not susceptible to SARS-like respiratory viruses anyway.

c) there's LOTS of money (aside from power, or elections, or bioweapons or anything else). Moderna had lost over a billion by last June, and their SEC prospectus said it was a gene therapy. Of the major players (Faux-Xi, etc., what are their investments / conflicts of interest)?

There are too d@mn MANY "that's fishy" red flags, all at the same time; and ALL in favor of rejecting the jab.

85 posted on 04/25/2021 4:36:22 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: palmer

“You still haven’t read what I wrote. If you are vaccinated and get COVID you are just as likely to be hospitalized and die as a non-vaccinated person who gets COVID.”

Ok but only 74 vaccinated people out of 77 million vaccinated died of covid.

Your chance of getting and dying of covid after being vaccinated is in all purposes near impossible -74 people out of 77 million died


86 posted on 04/25/2021 4:36:53 PM PDT by setter
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To: BeauBo
BFD, they're still wrenching their own arm out of its socket patting themselves on the back for being so *clever* about it.

Screw them all.

Troll.

87 posted on 04/25/2021 4:37:24 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: setter
You're lying through your teeth.

I'm raising mathematically and scientifically valid issues.

I can't help it that you're too stupid or dishonest to be able to follow them.

88 posted on 04/25/2021 4:38:23 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: billyboy15
Exactly right, just like the common flu as far as seriousness.

500,000 excess deaths last year in the U.S. alone? It ain't the flu, bro.

89 posted on 04/25/2021 4:40:10 PM PDT by MinorityRepublican
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To: setter

Suck on this, troll. Bioweapon.

https://pjmedia.com/news-and-politics/rick-moran/2021/04/25/the-wuhan-lab-theory-refuses-to-die-n1442637

(and if you object, you were the one who started mass-media, not me.)


90 posted on 04/25/2021 4:41:25 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: BeauBo

I believe you’re thinking of ADE.
Not what I meant.


91 posted on 04/25/2021 4:52:19 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: mrsmith

ADE (Antibody-dependent enhancement) is one way of describing the hyper immune response (in this case, dependent on being primed with pre-existing antibodies).

The mechanism by which the immune response does its damage, is through the over-production of pro-inflammatory cytokines - a cytokine storm.

Two ways of describing the same phenomena.


92 posted on 04/25/2021 5:08:15 PM PDT by BeauBo
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To: BeauBo

But I just meant taking the vax while you’re infected too. Not the same thing.

“No. People with COVID-19 who have symptoms should wait to be vaccinated until they have recovered from their illness and have met the criteria for discontinuing isolation; those without symptoms should also wait until they meet the criteria before getting vaccinated. This guidance also applies to people who get COVID-19 before getting their second dose of vaccine.”
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html

May be it’s just to keep infectious people out of the system of course.


93 posted on 04/25/2021 5:16:35 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: BeauBo

Looking around it appears there is no danger, they just want to keep infectious people away.
Though also it may work better to wait.

But no danger.


94 posted on 04/25/2021 5:30:16 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: SaxxonWoods
I wish we had an actual investigative, honest media.

Agreed .. we're being lied too continuously on several fronts. If this virus is something that has been done deliberately, then it would never become extremely lethal because of the very real possibility that it would come back on those who unleashed it.

However, if its purpose was to compel countless millions to inject themselves with something harmful, then that's an entirely different story.

95 posted on 04/25/2021 5:42:33 PM PDT by The Duke (Search for 'Sydney Ducks' and understand what is needed.)
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To: exDemMom
I know, many people hate “Big Pharma” and imagine that pharmaceutical companies are raking in money by the truckload. The reality is that R&D is incredibly expensive.

Why don't you start a GoFundMe? Use Sarah McLachlan and a bunch of puppies.

96 posted on 04/25/2021 5:44:28 PM PDT by Stentor
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To: BeauBo

Living in shit and dirty filthy conditions.

People suspected it would take a super variant of this COVID to take hold in such a filthy country.


97 posted on 04/25/2021 11:22:27 PM PDT by Starcitizen (So Indian H1B crybaby trash runs Free Republic moderation??? Seems so. )
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To: usconservative

raw materials from the USA on the way. Screw China and their 10% effective vaccine that just bred resistant virus - as planned no doubt.

In India, 350,000 new cases today - world record

“April 25 (UPI) — The Biden administration on Sunday announced it is allowing exports of raw materials needed by India to make a COVID-19 vaccine as it faces an exponential surge in deaths and new cases.

The United States has located supplies of materials necessary for India to ramp up its production of its homegrown Covishield vaccine and will immediately make them available ...”

https://www.upi.com/Top_News/US/2021/04/25/US-allows-exports-raw-materials-for-COVID-19-vaccines-to-India/7331619381928/


98 posted on 04/25/2021 11:32:09 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: MinorityRepublican

Sure, if you believe the bs numbers to begin with....I don’t.

Excess deaths many of which were caused by lack of preventative medical care, suicides brought on by china virus stress, alcohol and drug abuse and on and on.

Even the CDC admitted just 6% of deaths attributed to china virus were actually caused by it.


99 posted on 04/26/2021 1:20:20 AM PDT by billyboy15 (')
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To: entropy12

I simply do not believe the numbers reported on the china virus. It is really that simple.

The response to this thing is completely agenda driven and like the boy who cried wolf story this will impact greatly the government attempt to actually help should a real medical emergency arise in the future.

Although anecdotal I personally know half dozen people or more who have gone from scared to being ashamed of themselves for allowing the likes of Fascist Gaucho to do what he did to them.


100 posted on 04/26/2021 1:26:27 AM PDT by billyboy15 (')
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