I would approach it as, well, God made man and God made woman, and He was pleased with His creation the way it was. God didn't mess up, change His mind, and take either one back to swap parts around like you would a Mr. Potato Head.
There was a bumper sticker around several years ago that said "God doesn't make mistakes" -- and it seems to me that Genesis is pretty clear about this.
Just my $.02 - YMMV.
But I press on with the argument. You say God doesn't "mess up," and yet you know that people ARE born with disorders that require surgical and medical intervention, some of it extensive. For instance, babies are born as conjoined twins, and the surgeons have to reconfigure their "God-given" bodies. They can't live happily with their conjoined bodies as given by God. They need to be reengineered, and radically, to give each twin a body they can live with.
Trannies, we might hypothesize, have a similar radical problem. They bodies they were born are out of synch with their minds and emotions, their personalities. They need to be re-engineered to have a body they can live with, so they can be their "best selves." It's just like a baby born with one arm and one stump, will eventually get a prosthetic, maybe even a bionic arm.
Both the psychiatric profession and the gender-specialist surgeons will back them up on this, as well as, increasingly, courts and laws. Isn't it cruel to deny them the help and healing they need?
(Keep in mind I am posing this as a hypothetical question needing a Biblical answer.)