If Rome is the harlot city, as the majority opinion presumes, there is a problem in that it was never destroyed. It was sacked many centuries after Biblical times (in the late 4th and early 5th Centuries AD), but it was never burned or destroyed as depicted in Revelation. Jerusalem however was destroyed and burned in 70 AD and thereby correspondent to the prophecies of the Book of Revelation (e.g. Rev 18:18 inter al).
In the Old Testament, Jerusalem, and the people of Israel are called the harlot since they have committed adultery, forsaken the Lord, and are sleeping with false gods. Nowhere in the Old Testament is Rome or any pagan city called a harlot. But Jerusalem repeatedly is.
(Isa 1:20-21) But if you refuse and rebel [O, Israel], you shall be devoured by the sword; for the mouth of the LORD has spoken. {21} How the faithful city has become a harlot, she that was full of justice! Righteousness lodged in her, but now murderers.
.(Jer 2:19-20) Your wickedness will chasten you, and your apostasy will reprove you. Know and see that it is evil and bitter for you to forsake the LORD your God; the fear of me is not in you, says the Lord GOD of hosts. {20} For long ago you broke your yoke and burst your bonds; and you said, I will not serve. Yea, upon every high hill and under every green tree you bowed down as a harlot.