Posted on 08/28/2025 7:13:21 AM PDT by yesthatjallen
Abstract
Efforts to alleviate the psychological distress of gender dysphoria have included the use of exogenous estrogen (often with anti-androgens) to alter secondary sex characteristics of natal males. In response to the rapid increase in presenting cases among young people, extensive scrutiny has now been brought to bear on these medical interventions for minors, with ESCAP reporting “an urgent need for safeguarding clinical, scientific, and ethical standards.” However, due to the lack of systematic outcome data, the associated risk–benefit profile is unknown. Several recent systematic reviews have found the evidence of benefit to be of low or very low certainty, while some risks, such as infertility, have been long recognized. This paper compiles several emerging and accumulating safety signals in the medical literature. These range from increased rates of previously associated adverse outcomes with long-term estrogen use (e.g., acute cardiovascular events) to associations of estrogen use with newly identified adverse outcomes. Estrogen also induces changes in the brain, raising concerns for negative impacts on mood (e.g., depression) and cognition. These safety signals indicate the need for further investigation and a thorough systematic search for others, which may now be more evident due to the increased number of young people receiving these treatments. There is an urgent need for the evidence base to be improved with more studies, especially those with systematic long-term follow-up and those that can disentangle possible confounders, as well as systematic reviews to help interpret their reliability.
SNIP
(Excerpt) Read more at link.springer.com ...
"The research paper discusses emerging and accumulating safety signals for the use of estrogen among transgender women. The authors aim to compile and summarize several safety signals in the medical literature, including increased rates of previously associated adverse outcomes, such as acute cardiovascular events, and associations with newly identified adverse outcomes, such as changes in the brain that may impact mood and cognition.
Key findings include:
Increased cardiovascular risks, including venous thromboembolism (VTE) and stroke, with estrogen use in transgender women [50] [51].
Long-term estrogen use may exacerbate these risks, with a 5.1-fold increase in VTE incidence and a nearly 10-fold increase in ischemic stroke incidence [55].
Estrogen use may also induce changes in the brain, including increased ventricular volume and decreased brain volume, which may impact mood and cognition [90] [91][92].
Several studies have reported associations between estrogen use and increased risk of autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus [73] [75].
Estrogen use has been linked to increased risk of diabetes, with a 72% increase in HOMA-IR values, a measure of insulin resistance, in the first year of treatment [76].
Case reports have suggested that estrogen therapy may be an under-recognized cause of elevated triglyceride levels and potentially severe pancreatitis [79] [80].
There is also a possible link between estrogen use and increased risk of thyroid cancer, with a 0.34% prevalence in US military veteran transgender women records [82].
Other safety signals include increased risk of breast cancer, with a standardized incidence ratio (SIR) of 22.5 (95% CI 5.54–91.8) in comparison to non-TGNB men [86].
Adverse drug reaction reports have also suggested a possible link between estrogen use and meningiomas, as well as cardiovascular events [88] [89].
The authors conclude that these safety signals warrant further investigation and a thorough systematic search for others, which may now be more evident due to the increased number of young people receiving these treatments."
among transgender women ‘
they are not women
They are XY.
It always takes me a while to determine exactly what these articles are saying.
XX or XY are the ONLY two choices on the menu. Beef isn’t chicken any more than pork is fish.
Taking sex hormones is the biological equivalent of going into your computer’s root directory and making random code changes.
“Trans” = mentally ill (and not just a little bit)
As Jesse Watters "Tweeted" (X'd?) yesterday:
"The media is bad at pattern recognition. Just two years ago another trans 20-something walked into a Christian school in Nashville with a rifle and sh-t 3 kids and 3 adults. They buried the manifesto and locked down the case.
"We have seen trans sho-tings in Colorado and in Maryland. They even sh-t up an I.C.E. Facility in Texas.
Statistically, the trans population has been prone to violence. That's not villainizing - that's reality. And if you can't recognize reality, you are in danger." Media response: "Pattern Recognition is Racist and Sexist!"
This whole transgender mutilation is an abomination, regardless of the age of the person who has it done or to whom it is done. Indeed, it effectively compares with the hideous “experiments” that were perpetrated by Doktor Josef Mengele at Auschwitz. Hence, I refuse to refer to it as “gender affirming care,” instead I properly refer to it as Mengelization.
OK. The treatment is dangerous to the patient, and the consequences can be dangerous to the rest of us.
But here’s the unasked question: WHY, suddenly (w/n the last 10-15 years) have so many young people decided that they need to change their gender, and WHY are their parents supporting, or at least going along with this madness?
I am a woman who is a breast cancer survivor (13 years) and my tumor was hormone based.
They are certainly studying this possibility in young males receiving this hormone, and there will be those who sound the alarm, but they will be ignored along with actual research, as long as there is money to be made.
Estrogen fluctuations can trigger migraine headaches, a reason women have far more headaches than men.
It became popular.
There were some “closeted’ Transgender all the time. Extremally small population and they rarely seek medical treatment. But, with all the modern LGBTQ+ movement, a lot of people discovered the gay and the trans inside them.
Many (most) kids are somewhat confused on the sex issue. When they get into puberty, they normally grow out of it.
But now, these natural tendencies are supported, enhanced, made popular and “treated” with massive procedures.
Whole “transgender” care “medicine” were established and they are making big money out of it!
Money, money, money .................. Any “professional” defending trans crappola is after $$. Period.
If they are men transitioning to female wouldn’t they be XX?
Whip it.
Dr Mengele lives at John Hopkins. His spirit permeates modern medical practice.
Why are these concoctions being given to people? Why are children being mutilated based on some crazy disorder invented by psychiatrists, a pseudoscientific profession of drug pushers and brain butchers? The first thing these monsters do is cause harm.
Putting hormones into a body that is in every other way the opposite sex has to bring about bad changes. Long-term if not short.
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