Scientists Created Male and Female Cells from a Single Person

Scientific American ^

[FarCenter]

Most people have two sex chromosomes, either two X’s or an X and a Y, which give rise to female or male biological attributes on a spectrum. Studies suggest these chromosomes also have much broader effects, contributing to processes that include immune system function, neuronal development, disease susceptibility and reactions to drugs. But scrutinizing the specific role of X and Y chromosomes is challenging. With current tools, it is difficult to disentangle the effects of genes versus hormones, for example.

Now scientists have devised a tool that could overcome this obstacle—by generating XX and XY cells from a single person for the first time. This unique set of cells could help researchers tackle long-standing questions about how sex chromosomes affect disease and the role they play in early development.

“This is a really cool set of cell lines,” says Barbara Stranger, a professor of pharmacology at Northwestern University, who was not involved in this study. “We’ve had cell lines from males and females before, but the fact that they’re coming from same person with just the same sex chromosome difference—it’s a big step.”

Benjamin Reubinoff, a professor of obstetrics and gynecology at the Hadassah Medical Center in Israel, and his team began the project to overcome barriers facing investigations of sex differences in humans. Currently there are two major ones, according to Reubinoff: the difficulty of separating chromosomal and hormonal effects and the inability to pinpoint the effects of X and Y chromosomes while ruling out contributions from the rest of a person’s genetic makeup. “The main reason for doing this study was the lack of a good model to study differences between males and females in humans,” Reubinoff says. “There have been animal models, but a model in humans was not available.”

To create such a model, Reubinoff, his former M.D. and Ph.D. student Ithai Waldhorn and their colleagues first obtained white blood cells previously collected from a person with Klinefelter syndrome, a condition in which male individuals are born with an extra X chromosome. The cells came from the repositories of the Coriell Institute for Medical Research, where people donate samples for use in a wide range of biomedical research projects. The donor had a rare “mosaic” form of the condition, in which some of their cells had three sex chromosomes (XXY), some had two X chromosomes, and some had one X and one Y. The researchers reprogrammed all three cell types into induced pluripotent stem cells, which have the capacity to self-renew and to develop into neurons, muscle cells or other cell types.

Ultimately the team generated XX and XY cells that—apart from their sex chromosomes—were genetically identical. The researchers then conducted a series of experiments replicating findings from prior studies with other models. For example, they confirmed previously reported differences in genes that were turned on in XX or XY cells. They also coaxed their stem cells to develop into immature versions of neurons and found evidence of previously reported sex differences in early neural development. “It was reassuring to see that the model really shows differences between the sexes that were reported from other systems,” Reubinoff says. The findings were published last month in Stem Cell Reports.

[dfwgator]

[frank ballenger]

So as to the scientist, male and female he created them.

[Hostage]

This has been known for a long time. It’s doable with females, giving rise decades ago to statements that males are not required for survival of the species.

[stars & stripes forever]

If these mad scientists are open to publicizing this human experiment, what are they doing in secret?

[38special]

Cue the Big Mike pics

[Maudeen]

You don’t mess with God’s creation . . .. there is going to be a grand finale one day when everyone gives an account of what they did with Jesus. . . .

For it is written: “ As I live, says the LORD, Every knee shall bow to Me, And every tongue shall confess to God.” (Romans 14:11)

that at the name of Jesus every knee should bow, of those in heaven, and of those on earth, and of those under the earth, and that every tongue should confess that Jesus Christ is Lord, to the glory of God the Father. (Philippians 2:10-11)

[rlmorel]

"...“This is a really cool set of cell lines,” says Barbara Stranger, a professor of pharmacology at Northwestern University, who was not involved in this study. “We’ve had cell lines from males and females before, but the fact that they’re coming from same person with just the same sex chromosome difference—it’s a big step..."

"...Really cool set of cell lines..."

But, a big step towards...what?

[alternatives?]

How can they have male and female cells? They haven’t had time to identify themselves.

[TribalPrincess2U]

Yeah, we need more freaks!

[Dilbert San Diego]

Well if everyone can produce both male and female cells, then none of us are really considered male or female.

Heck we are all transgender. Sex and gender are simply social constructs.

And we are not allowed to say anything to the contrary because SCIENCE is telling us about this. And we are told we must not ever doubt the science.

[Robert DeLong]

Created is a far cry from retrieved. Color me totally unimpressed.

[VTenigma]

Why?

[lee martell]

Asexual reproduction.
Making Babies, but without all the fun, expense and social complications.
We can be like the Nematodes (aka Earthworms)

[Blood of Tyrants]

What could go wrong?

[grey_whiskers]

The next step is bioengineering people who really can go **** themselves...

[BereanBrain]

so, there is only male and female again? not 101 genders, flavor of the day?

[jonrick46]

They should have tried taking a rib.

[Bob434]

interesting statement by Jenna Ellison

Jenna Ellis 🍊🦅

@JennaEllisEsq

If I am a “bigot” for refusing to affirm your lifestyle of being LGBTQ, what are you for refusing to affirm my lifestyle of being Christian?

https://twitter.com/JennaEllisEsq/status/1605469227841748992?cxt=HHwWgICg9bXw4scsAAAA

and another when folks railed against her for ‘not affirming people’s decisions’

Jenna Ellis 🍊🦅
@JennaEllisEsq
Actually people like you falsely accuse people like me of “hating” when Christians love people by not affirming every type of lifestyle choice. Sounds like you’re not affirming my choice to be a Christian, so by your own standard, you’re not only a liar but a bigot. 🤷🏼‍♀️

https://twitter.com/JennaEllisEsq/status/1600624761897472000

of course the left will then say “Well we don’t affirm your choice out of love for you”

[spirited irish]

"Now scientists have devised a tool that could overcome this obstacle—by generating XX and XY cells from a single person for the first time. This unique set of cells could help researchers tackle long-standing questions about how sex chromosomes affect disease and the role they play in early development."

All humans have within them both kindly Dr. Jekyll and evil Mr Hyde. Dr Jekyll desires to use this tool (power) for good, but evil My Hyde, who lusts for power, already perceives how the tool can be used for evil.