Posted on 09/28/2022 2:15:17 PM PDT by NoLibZone
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy.
In vitro, HCQ effectively inhibits viral entry, but its use in the clinic has been hampered by conflicting results.
A better understanding of HCQ’s mechanism of actions in vitro is needed. Recently, anesthetics were shown to disrupt ordered clusters of monosialotetrahexosylganglioside1 (GM1) lipid. These same lipid clusters recruit the SARS-CoV-2 surface receptor angiotensin converting enzyme 2 (ACE2) to endocytic lipids, away from phosphatidylinositol 4,5 bisphosphate (PIP2) clusters. Here we employed super-resolution imaging of cultured mammalian cells (VeroE6, A549, H1793, and HEK293T) to show HCQ directly perturbs clustering of ACE2 receptor with both endocytic lipids and PIP2 clusters.
In elevated (high) cholesterol, HCQ moves ACE2 nanoscopic distances away from endocytic lipids. In cells with resting (low) cholesterol, ACE2 primarily associates with PIP2 clusters, and HCQ moves ACE2 away from PIP2 clusters—erythromycin has a similar effect. We conclude HCQ inhibits viral entry through two distinct mechanisms in high and low tissue cholesterol and does so prior to inhibiting cathepsin-L. HCQ clinical trials and animal studies will need to account for tissue cholesterol levels when evaluating dosing and efficacy.
(Excerpt) Read more at nature.com ...
What’s the bottom line?
Well, knock me over with a feather! Who would’ve thunk it?!
Wow! Now there’s something you don’t see much of tHese days. A real study. Could it be….hmmmm….science?
Because I can’t get HCQ, I take Quercetin with zinc and vitamins as a prophylactic. It’s worked so far.
Hard to believe, isn't it? An impeccably credentialed MD, PhD epidemiologist from Yale of all places, who will tell you about hydroxychloroquine's clinical successes! He gives Twitter the vapors!
Genocide hasn’t peaked yet.
Interesting and encouraging research. Hopefully other quality studies will add to this knowledge.
Holding for “horse paste” replies.
Oddly enough, no shills showed up.
Radio is full of ads, though.
If you go to the Mayo Clinic link, you'll find this info when you scroll down: Portions of this document last updated: Aug. 01, 2022
There are papers from a couple of years ago that showed this.
The medical community knew.
Bookmark for nature peer reviewed study
The radio and tv ads are an abomination- they are disgusting and make me nauseous- I have to change channel
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