Posted on 09/28/2022 2:15:17 PM PDT by NoLibZone
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy.
In vitro, HCQ effectively inhibits viral entry, but its use in the clinic has been hampered by conflicting results.
A better understanding of HCQ’s mechanism of actions in vitro is needed. Recently, anesthetics were shown to disrupt ordered clusters of monosialotetrahexosylganglioside1 (GM1) lipid. These same lipid clusters recruit the SARS-CoV-2 surface receptor angiotensin converting enzyme 2 (ACE2) to endocytic lipids, away from phosphatidylinositol 4,5 bisphosphate (PIP2) clusters. Here we employed super-resolution imaging of cultured mammalian cells (VeroE6, A549, H1793, and HEK293T) to show HCQ directly perturbs clustering of ACE2 receptor with both endocytic lipids and PIP2 clusters.
In elevated (high) cholesterol, HCQ moves ACE2 nanoscopic distances away from endocytic lipids. In cells with resting (low) cholesterol, ACE2 primarily associates with PIP2 clusters, and HCQ moves ACE2 away from PIP2 clusters—erythromycin has a similar effect. We conclude HCQ inhibits viral entry through two distinct mechanisms in high and low tissue cholesterol and does so prior to inhibiting cathepsin-L. HCQ clinical trials and animal studies will need to account for tissue cholesterol levels when evaluating dosing and efficacy.
(Excerpt) Read more at nature.com ...
Wow! What a surprise!
You are hereby banished from the kingdoms of Lord Fauci, Lord Zuckerberg and Lord Dorsey!
“Nature” is super respected.
I’m surprised they allowed this to be published, but, perhaps, Sars is water under the bridge and legitimate work can now be spoken to.
Well duh... quite a few doctors have been saying that for 2 years +... and getting threatened with losing their medical license for doing so (or for prescribing it).
REPENT NOW!!!! The FR Vaxers will be along shortly to show your the errors of your ways!!
Don’t even have to ping them, they will arrive unbidden.
Thanks, NoLibZone.
*PING* to you others.
Kind of like Demmons
So much blood on the hands of these criminals.
https://academic.oup.com/aje/article/190/7/1435/6038970?login=false
The largest nonrandomized but controlled outpatient trial, of HCQ + zinc versus zinc alone, conducted as a national study in the modernized health-care system across the entire country of Saudi Arabia and including nearly 8,000 patients, showed a dramatic and very significant 4–5-fold mortality reduction in the HCQ + zinc arm (7). Worldwide, countries using HCQ or ivermectin as the basis component for early outpatient treatment have per capita COVID-19 mortality proportions 4-fold or more lower than that of the United States (8, 9).
More at link.
Doesn’t make any difference now. All the shots and boosters have been taken, people are brainwashed to take more, and now they just don’t care. All ready to start the next plandemic ... what, is that ebola on the rise, will Ivermectin or HCQ not work against it.
Bkmk
Agree!!
They KNEW HCQ was an excellent preventative and treatment.
Blood is definitely on their evil hands.
And ... the prolonged pandemic emergency allowed many changes to election protocols in 2020 resulting in a Biden “win”. The USA and much of the world is paying for that now.
Even the beagles knew Fauci was lying when he said he was doing this for the greater good.
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy.Here's the "controversies" over it:
Bkmk
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.