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New Pfizer drug and ivermectin
Dr. John Campbell YouTube Channel ^ | November 9, 2021 | Dr. John Campbell

Posted on 11/12/2021 9:53:27 AM PST by ProtectOurFreedom

(This is from Dr. Campbell's YouTube description) New Pfizer antiviral and ivermectin, a pharmacodynamic analysis

New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄

PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,

(Excerpt) Read more at youtube.com ...


TOPICS: Culture/Society; Government; News/Current Events; United Kingdom
KEYWORDS: chat; chinavirustreatment; covid19; ivermectin; ivm; molnupiravir; paxlovid; pfizer; waronivermectin; youtube
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To: ProtectOurFreedom

It might have been Dr. Pierre Kory. I seem to recall a youtube video of him talking about increasing dosage for the Delta variant. Or maybe Dr. Mobeen Syed (Dr. Been on youtube.)

I posted this a few months ago when the FLCCC doctors were trying to decide how to alter their protocol.
https://freerepublic.com/focus/chat/3985303/posts?page=38#38


41 posted on 11/12/2021 4:31:05 PM PST by FreedomForce
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To: semimojo

RE: Do you have any links?

Read this study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/

Search for the word “protease” in the article.


42 posted on 11/12/2021 5:57:58 PM PST by SeekAndFind
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To: SeekAndFind
Read this study:

The subtitle of your study:

"Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach..."

In silico means it's a computer model.

Do you have anything clinical?

43 posted on 11/12/2021 6:23:43 PM PST by semimojo
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To: semimojo

Here’s an in vitro study.

https://www.researchgate.net/journal/Communications-Biology-2399-3642/publication/348626948_Identification_of_3-chymotrypsin_like_protease_3CLPro_inhibitors_as_potential_anti-SARS-CoV-2_agents/links/60091af1299bf14088adbf5e/Identification-of-3-chymotrypsin-like-protease-3CLPro-inhibitors-as-potential-anti-SARS-CoV-2-agents.pdf


44 posted on 11/12/2021 7:10:30 PM PST by FreedomForce
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To: FreedomForce
Here’s an in vitro study.

Right, a test tube study, but the claim was clinical studies.

Does anyone have any of those?

45 posted on 11/12/2021 7:14:53 PM PST by semimojo
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To: semimojo

From the discussion section of the study in the previous reply:

“Ivermectin is known to be effective against many positive- sense, single stranded RNA viruses such as Zika, Dengue, Yellow fever, West nile, Venezuelan equine encephalitis, Chikungunya, Semliki forest, Sindbis, Rorcine Reproductive and Respiratory Syndrome, and Human immunodeficiency-1 viruses38. The list of anti-viral effects of ivermectin against other RNA and DNA viruses were summarized in a recent review38. Earlier studies have demonstrated that the possible anti-viral mechanism of iver- mectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19–23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).
In conclusion, the SARS-CoV-2 specific 3CLpro enzyme was used as a target to screen the potential drugs that have high binding affinity for 3CLpro since it plays a major role during viral replication. We have identified that boceprevir, micafungin, ombitasvir, paritaprevir, and tipranavir exhibited partial inhibi- tory effect, whereas ivermectin was able to completely inhibit the SARS-COV-2 3CLpro enzymatic activity in vitro at the tested doses. “


46 posted on 11/12/2021 7:20:23 PM PST by FreedomForce
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To: ProtectOurFreedom

bkmk


47 posted on 11/12/2021 7:24:33 PM PST by sauropod
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To: semimojo

Clinical trials to determine if ivermectin is useful in treating COVID or clinical trials to determine if ivermectin is useful in treating COVID because it’s a protease inhibitor?

I’ve seen enough of the former to convince me of that, but I’m not aware of any of the latter.


48 posted on 11/12/2021 7:32:11 PM PST by FreedomForce
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To: FreedomForce; SeekAndFind
...in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials...

I heard here it was determined to be a protease inhibitor in clinical trials. Are these the trials that showed that? Where are the results?

...ivermectin was able to completely inhibit the SARS-COV-2 3CLpro enzymatic activity in vitro at the tested doses...

Nice test tube result.

49 posted on 11/12/2021 7:32:45 PM PST by semimojo
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To: FreedomForce
Clinical trials to determine if ivermectin is useful in treating COVID or clinical trials to determine if ivermectin is useful in treating COVID because it’s a protease inhibitor?

"Interestingly, Ivermectin also works as a protease inhibitor as per clinical studies."

50 posted on 11/12/2021 7:36:14 PM PST by semimojo
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To: semimojo

Well, I didn’t make that claim, and I’m not inclined to sift through the research to try to verify it. The discussion is interesting, but if I get COVID, I’m going straight for Regeneron.


51 posted on 11/12/2021 7:43:39 PM PST by FreedomForce
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To: FreedomForce
...if I get COVID, I’m going straight for Regeneron.

Hope to beat you there. Get in line...

52 posted on 11/12/2021 7:48:30 PM PST by semimojo
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To: semimojo; FreedomForce

Here are more studies on the mechanism of Ivermectin on SARS-COV2

https://www.nature.com/articles/s42003-020-01577-x

and here:

https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full


53 posted on 11/12/2021 8:13:23 PM PST by SeekAndFind
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To: semimojo

Lots of different tests are simultaneously under way by different organizations in different parts of the world: In Silico, In Vitro, human RCTs In Vivo.


54 posted on 11/12/2021 8:16:19 PM PST by ProtectOurFreedom (“…in any great disaster, there's a Harvard man in the middle of it.” ~ Thomas Sowell)
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To: SeekAndFind
Here are more studies on the mechanism of Ivermectin on SARS-COV2

"Computational molecular modeling was used to screen 3987 FDA approved drugs..."

and here:

"Homology modeling of the viral proteins was performed using the SWISS-MODEL server2 with default settings.

More to the point, that study didn't characterize ivermectin as a protease inhibitor:

"Many drugs have been found to possess potential antiviral activity against SARS-CoV-2. These include old antimalarial drugs (chloroquine phosphate, chloroquine, and hydroxychloroquine) (Wang M. et al., 2020), an anthelmintic drug (ivermectin) (Caly et al., 2020), viral RNA polymerase inhibitors (remdesivir and favipiravir) (National Health Commission of the People’s Republic of China, 2020; Wang M. et al., 2020) and viral protease inhibitors (Mugisha et al., 2020)."

I really don't care what you think of ivermectin but it matters when you tell people something's been shown in clinical studies when it hasn't.

55 posted on 11/12/2021 9:41:03 PM PST by semimojo
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To: ProtectOurFreedom; SeekAndFind
Lots of different tests are simultaneously under way by different organizations in different parts of the world: In Silico, In Vitro, human RCTs In Vivo.

That's great, and when they're done maybe we can say ivermectin's been shown to be a protease inhibitor in clinical studies. Until then let's tap the brakes.

Actually, I'm not sure you could even demonstrate it in a clinical trial at all.

56 posted on 11/12/2021 9:47:00 PM PST by semimojo
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To: ProtectOurFreedom
Regarding the Medications that can be effective, IIRC NIH did research back when SARS was circulating, and HCQ was found to be effective. And it was stockpiled.

DJT had an executive order to allow people to try HCQ, but someone in some agency sabotaged it in their formulation of the rules. I don't recall all the details - it's been quite a few months since I read that stuff.

57 posted on 11/12/2021 9:58:31 PM PST by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: semimojo; ProtectOurFreedom

RE: Until then let’s tap the brakes.

MEANING WHAT?

Revoke the licenses of doctors who prescribe it for Covid?


58 posted on 11/13/2021 3:49:22 AM PST by SeekAndFind
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To: semimojo; ProtectOurFreedom

RE: Actually, I’m not sure you could even demonstrate it in a clinical trial at all.

Can you explain to us why you think not?


59 posted on 11/13/2021 4:59:11 AM PST by SeekAndFind
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To: SeekAndFind
MEANING WHAT?

Meaning let's slow down on making claims we don't have evidence for.

60 posted on 11/13/2021 6:15:24 AM PST by semimojo
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