Posted on 11/12/2021 9:53:27 AM PST by ProtectOurFreedom
(This is from Dr. Campbell's YouTube description) New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
(Excerpt) Read more at youtube.com ...
It might have been Dr. Pierre Kory. I seem to recall a youtube video of him talking about increasing dosage for the Delta variant. Or maybe Dr. Mobeen Syed (Dr. Been on youtube.)
I posted this a few months ago when the FLCCC doctors were trying to decide how to alter their protocol.
https://freerepublic.com/focus/chat/3985303/posts?page=38#38
RE: Do you have any links?
Read this study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
Search for the word “protease” in the article.
The subtitle of your study:
"Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach..."
In silico means it's a computer model.
Do you have anything clinical?
Right, a test tube study, but the claim was clinical studies.
Does anyone have any of those?
From the discussion section of the study in the previous reply:
“Ivermectin is known to be effective against many positive- sense, single stranded RNA viruses such as Zika, Dengue, Yellow fever, West nile, Venezuelan equine encephalitis, Chikungunya, Semliki forest, Sindbis, Rorcine Reproductive and Respiratory Syndrome, and Human immunodeficiency-1 viruses38. The list of anti-viral effects of ivermectin against other RNA and DNA viruses were summarized in a recent review38. Earlier studies have demonstrated that the possible anti-viral mechanism of iver- mectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19–23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).
In conclusion, the SARS-CoV-2 specific 3CLpro enzyme was used as a target to screen the potential drugs that have high binding affinity for 3CLpro since it plays a major role during viral replication. We have identified that boceprevir, micafungin, ombitasvir, paritaprevir, and tipranavir exhibited partial inhibi- tory effect, whereas ivermectin was able to completely inhibit the SARS-COV-2 3CLpro enzymatic activity in vitro at the tested doses. “
bkmk
Clinical trials to determine if ivermectin is useful in treating COVID or clinical trials to determine if ivermectin is useful in treating COVID because it’s a protease inhibitor?
I’ve seen enough of the former to convince me of that, but I’m not aware of any of the latter.
I heard here it was determined to be a protease inhibitor in clinical trials. Are these the trials that showed that? Where are the results?
...ivermectin was able to completely inhibit the SARS-COV-2 3CLpro enzymatic activity in vitro at the tested doses...
Nice test tube result.
"Interestingly, Ivermectin also works as a protease inhibitor as per clinical studies."
Well, I didn’t make that claim, and I’m not inclined to sift through the research to try to verify it. The discussion is interesting, but if I get COVID, I’m going straight for Regeneron.
Hope to beat you there. Get in line...
Here are more studies on the mechanism of Ivermectin on SARS-COV2
https://www.nature.com/articles/s42003-020-01577-x
and here:
https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full
Lots of different tests are simultaneously under way by different organizations in different parts of the world: In Silico, In Vitro, human RCTs In Vivo.
"Computational molecular modeling was used to screen 3987 FDA approved drugs..."
and here:
"Homology modeling of the viral proteins was performed using the SWISS-MODEL server2 with default settings.
More to the point, that study didn't characterize ivermectin as a protease inhibitor:
"Many drugs have been found to possess potential antiviral activity against SARS-CoV-2. These include old antimalarial drugs (chloroquine phosphate, chloroquine, and hydroxychloroquine) (Wang M. et al., 2020), an anthelmintic drug (ivermectin) (Caly et al., 2020), viral RNA polymerase inhibitors (remdesivir and favipiravir) (National Health Commission of the People’s Republic of China, 2020; Wang M. et al., 2020) and viral protease inhibitors (Mugisha et al., 2020)."
I really don't care what you think of ivermectin but it matters when you tell people something's been shown in clinical studies when it hasn't.
That's great, and when they're done maybe we can say ivermectin's been shown to be a protease inhibitor in clinical studies. Until then let's tap the brakes.
Actually, I'm not sure you could even demonstrate it in a clinical trial at all.
DJT had an executive order to allow people to try HCQ, but someone in some agency sabotaged it in their formulation of the rules. I don't recall all the details - it's been quite a few months since I read that stuff.
RE: Until then let’s tap the brakes.
MEANING WHAT?
Revoke the licenses of doctors who prescribe it for Covid?
RE: Actually, I’m not sure you could even demonstrate it in a clinical trial at all.
Can you explain to us why you think not?
Meaning let's slow down on making claims we don't have evidence for.
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