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Real-World Study Links Pfizer Vax to High Risk of Myocarditis
Med Page Today ^ | August 25, 2021 | Molly Walker

Posted on 08/26/2021 6:18:15 AM PDT by george76

Though separate cohort found even higher risk with COVID infection..

The Pfizer COVID-19 mRNA vaccine was found to be associated with a threefold increased risk of myocarditis, according to a real-world case-control study from Israel.

Vaccination had a strong association with an increased risk of myocarditis (risk ratio [RR] 3.24, 95% CI 1.55-12.44), as well as increased risks of lymphadenopathy (RR 2.43, 95% CI 2.05-2.78), appendicitis (RR 1.40, 95% CI 1.02-2.01), and herpes zoster infection (RR 1.43, 95% CI 1.20-1.73), reported Ran Balicer, MD, of Clalit Health Services in Tel Aviv, and colleagues.

However, in a separate cohort, infection with SARS-CoV-2 was associated with a higher risk of myocarditis (RR 18.28, 95% CI 3.95-25.12), as well as other cardiovascular complications, including acute kidney injury (RR 14.83, 95% CI 9.24-28.75), pulmonary embolism (RR 12.14, 95% CI 6.89-29.20), and intracranial hemorrhage (RR 6.89, 95% CI 1.90-19.16), the authors wrote in the New England Journal of Medicine.

They noted that vaccination was "substantially protective" against anemia, acute kidney injury, intracranial hemorrhage, and lymphopenia.

Balicer's group examined data from the largest healthcare organization in Israel to compare incidence of adverse events among vaccinated individuals versus unvaccinated individuals, and estimated the effects of SARS-CoV-2 infection on these adverse events.

Participants in the vaccination cohorts were 16 years old and older, had been in the health organization for a full year, had no prior COVID-19 infection, and had no contact with the healthcare system in the last 7 days. Notably, populations with confounders, such as healthcare workers, long-term care facility residents, or people confined to their home for medical reasons, were excluded.

From Dec. 20, 2020 to May 24, 2021, eligible people vaccinated on a particular day were matched to eligible unvaccinated controls by age, sex, place of residence, socioeconomic status, and population sector. The study included 21 days of follow-up after the first and second doses of Pfizer vaccine. For each adverse event, patients were followed from the day of matching until documentation of the adverse event, 42 days, the end of the study period, or death.

To "place the magnitude of the adverse effects of the vaccine in context," Balicer and team also estimated the effects of SARS-CoV-2 infection on these same adverse effects during the 42 days after diagnosis.

Overall, 884,828 people each were included in the vaccination cohort and the unvaccinated cohort, though 235,541 in the unvaccinated cohort had to be rematched following vaccination. The researchers also included 173,106 people with COVID-19 infection matched with the same number of uninfected people.

The median age of the eligible cohort of 1,736,832 people was 43, and 48% were women. Median age in the vaccination cohorts was 38. Median age of the infection cohort was 36, and 54% were women.

While it may be tempting to compare the risk differences between vaccination and infection, the authors cautioned against this.

"The effects of vaccination and of SARS-CoV-2 infection were estimated with different cohorts," they wrote. "Thus, they should be treated as separate sets of results rather than directly compared."

Limitations to the study included that study participants were not randomly assigned according to exposures, which could introduce confounding and bias, and that the matching process resulted in a study population whose median age was 5 years younger than the eligible population. In addition, certain high-risk populations were excluded from the study.


TOPICS: Culture/Society; Israel; News/Current Events; Politics/Elections
KEYWORDS: covid; covid19; failure; heart; heartfailure; moderna; mrna; myocarditis; pericarditis; pfizer; pfizermrnavaccine; pfizervaccine; pfizervax; vaccination; vaccine; vaccines; vax
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Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms can include shortness of breath, chest pain, decreased ability to exercise, and an irregular heartbeat. .

Complications may include heart failure..

https://en.wikipedia.org/wiki/Myocarditis

1 posted on 08/26/2021 6:18:15 AM PDT by george76
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To: george76

Nope. FR experts said it’s safe and 95% effective...


2 posted on 08/26/2021 6:19:36 AM PDT by EEGator
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To: EEGator

The vaccines are totally safe—except when they are not...

When they are not the censors come out of the wood-work to keep the secret.


3 posted on 08/26/2021 6:21:55 AM PDT by cgbg (A kleptocracy--if they can keep it. Think of it as the Cantillon Effect in action.)
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To: george76

I had the J&J vaccine and 2 weeks later had appendicitis, must just be a coincidence.


4 posted on 08/26/2021 6:22:55 AM PDT by where's_the_Outrage? (Drain the Swamp. Build the Wall.)
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To: where's_the_Outrage?

Wait until the third shot.
In 6 months time no less.
Great vaccine.


5 posted on 08/26/2021 6:26:57 AM PDT by EEGator
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To: george76

As I & others have stated prior, this was the reason for the fast-track ‘approval’.

Israel was only ground zero.


6 posted on 08/26/2021 6:28:38 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: george76

“to compare incidence of adverse events among vaccinated individuals versus unvaccinated individuals, and estimated the effects of SARS-CoV-2 infection on these adverse events.“

ESTIMATED the effects from the real infection. Nothing like comparing real data and stacking it against an ESTIMATION.


7 posted on 08/26/2021 6:31:03 AM PDT by walkingdead (We are sacrificing American youth's future on the altar of our own fear. And it is a travesty.)
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*


8 posted on 08/26/2021 6:32:01 AM PDT by PMAS (Vote with your wallets, there are 80 million of us - No China made, No Amazon)
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To: george76

This is on my list of reasons why I won’t get the vax.

My family has a history of heart disease and at 70 I have no issues that I know of. I’m not going to ask for trouble with this vax.


9 posted on 08/26/2021 6:33:42 AM PDT by laplata
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To: laplata; Titus-Maximus; Chode; Jane Long

The US Food and Drug Administration added a warning about the risk of myocarditis and pericarditis to fact sheets for Moderna and Pfizer-BioNTech Covid-19 vaccines .. particularly after the second dose ..

https://freerepublic.com/focus/f-news/3984566/posts


10 posted on 08/26/2021 6:40:40 AM PDT by george76 (Ward Churchill : Fake Indian, Fake Scholarship, and Fake Art)
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To: george76

Thanks, george76!


11 posted on 08/26/2021 6:42:01 AM PDT by laplata
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To: laplata

Just take preventive steps and supplements and get a COVID PCR test the instant you feel symptoms so you can get a doctor to prescribe the monoclonal antibodies. Make sure your O2 is above 93% using an oximeter.

At your age, you will have an immediate infusion at an outpatient clinic.


12 posted on 08/26/2021 6:56:36 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: EEGator

Announced today boosters are going to be required every 6 months.
I guess you do that until you drop dead, or the vaccine resistant variant mutates because of all the vaccines,and there will be nothing to combat it,then you are locked in your home if you have survived that long


13 posted on 08/26/2021 7:05:43 AM PDT by ballplayer
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To: EEGator

Nope. FR experts said it’s safe and 95% effective...
****************************************
You forgot to add all reactions are rare


14 posted on 08/26/2021 7:11:23 AM PDT by Joshua (Keep paying attention to the shiny orb!)
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To: ConservativeMind

Thanks.


15 posted on 08/26/2021 7:11:55 AM PDT by laplata
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To: george76

wonderful


16 posted on 08/26/2021 7:14:06 AM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. P144:1)
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To: ballplayer

If something isn’t working, damn it, do it over and over!...


17 posted on 08/26/2021 7:44:10 AM PDT by EEGator
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To: ballplayer

Oh heck NO!


18 posted on 08/26/2021 8:00:23 AM PDT by Jaded (Pope Francis? Definitely NOT a fan... miss the last guy )
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To: ballplayer

19 posted on 08/26/2021 8:05:19 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: george76
Rush to make the vaccines. Create a rubber stamp study. Approve the vaccine, then wring hands over the problems that were already known. While simultaneously making alternative treatments difficult.

Remind me again, the CDC claims to be a public health agency?

20 posted on 08/26/2021 8:21:30 AM PDT by Widget Jr
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