You’re too kind.
“protein lasts longer”? Apropos of WTF point is she trying to make?
I had a hard time with it, but I’m only a lowly family practitioner of 30 years, with more than a passing interest in virology, infectious disease, allergy/immunology.
Just a note here, in case such a scenario should arise: Back in the dark ages of pre-molecular biology the “central tenet” of biology was DNA produces RNA which produces PROTEIN.
Stanley Prusiner tuned that on its head when he proved that the several spongiform encephalopathies such as Kuru, CJD (and BSE, Scrapie) were caused by PRotein Infections OrgaNisms: PRIONs.
I’ve got a pet theory that injecting synthetic mRNA (keep in mind, NO organic chemical process is 100% accurate, I can guaran-freaking-tee you SOME of those mRNA strands are NOT exact copies of the desired spike protein epitope mRNA) into a living organism MAY have as disastrous down-stream unpredictable results as the PRIONs have.
When some outside stimulus calls for a cell to produce a protein, DNA is transcribed into an mRNA strand (several of them) and sent to the endoplasmic reticulum of the cell where Ribosomes transcribe the mRNA into proteins which are used in the cell, or sent OUT of the cell.
What mechanisms SUPPRESS the DNA transcription process? Negative feedback from the mRNA concentration? The end-product inhibiting signals leading to their production.
I don’t know. It’s been 30+ years since I took molecular biology at UCSD under the tutelage of some awesome professors/staff.
So artificial mRNA is brought into cells to produce proteins, what shuts off the production?
What happens to the “mutant” proteins produced by the inaccurate mRNA copies out of the lab?
We’ll know in a few years for sure. You heard it here first
Oh, and don’t think the single-stranded DNA of the J&J vaccine is benign either.
Experimental. Investigational. Emergency Use Authorization.
I’ve had COVID19, as did my wife. Decades in the Army, combat zones, incoming rounds in our helicopters from Khmer rouge ‘92-’93, mine fields, incoming mortar rounds to our camp, I NEVER felt closer to dying than the month I was sick with the ‘rona. My wife was hospitalized, it was horrible.
That said, I would NEVER get any of the vaccines for it and, as I’ve already HAD the virus, studies are showing that’s as good (better) than the vaccine.
Awesome post. BRAVO!
After the mRNA delivers its instructions the proteins are made and the mRNA dissolves and no more is made. mRNA doesn't last very long. Basic biology. The cells don't live forever either. Even if theoretically this mRNA had supernatural powers and didn't dissolve and the production continued nonstop the cell would eventually explode and that would certainly end any further production.
Obvious propaganda. < / sarcasm >
Thank you for some Saturday morning sanity in this thread.
“That said, I would NEVER get any of the vaccines for it and, as I’ve already HAD the virus, studies are showing that’s as good (better) than the vaccine.”
I remember a time when we did not need a study to understand that surviving a virus was as good or better than a vaccine.
Now they recommend vaccine even if you have recovered from covid. What could our immune system hope to learn from the vaccine that it did not learn from the virus itself?
This whole vaccine push is wrapped in absolute nonsense.
Forgot to say your post #25 was great, I recommend everyone read it.
The big elephant in the room is exactly what you stated, what shuts down production. I have not heard a good answer.
Might be interested in this discussion of prion disease. Sorry about the lost formatting.
https://ijvtpr.com/index.php/IJVTPR/article/view/23/36
A Possible Link to Prion Diseases and NeurodegenerationPrion diseases are a collection of neurodegenerative diseases that are induced through the misfolding of important bodily proteins, which form toxic oligomers that eventually precipitate out as fibrils causing widespread damage to neurons. Stanley Prusiner first coined the name `prion’ to describe these misfolded proteins (Prusiner, 1982). The best-known prion disease is MADCOW disease (bovine spongiform encephalopathy), which became an epidemic in European cattle beginning in the 1980s. The CDC web site on prion diseases states that “prion diseases are usually rapidly progressive and always fatal.”(Centers for Disease Control and Prevention, 2018). It is now believed that many neurodegenerative diseases, including Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) may be prion diseases, and researchers have identified specificproteinaceous infectious particles linked to these diseases (Weickenmeier et al., 2019).Furthermore, researchers have identified a signature motif linked to susceptibility to misfolding into toxic oligomers, called the glycine zipper motif. It is characterized by a pattern of two glycine residues spaced by three intervening amino acids, represented as GxxxG. The bovine prion linked to MADCOW has a spectacular sequence of ten GxxxGs in a row (see uniprot.org/uniprot/P10279).More generally, the GxxxG motif is a common feature of transmembrane proteins, and the glycines play an essential role in cross-linking α-helices in the protein (Mueller et al., 2014). Prionproteins become toxic when the α-helices misfold as β-sheets, and the protein is then impaired in its ability to enter the membrane (Prusiner, 1982). Glycines within the glycine zipper transmembrane motifs in the amyloid-β precursor protein (APP) play a central role in the misfolding of amyloid-β linked to Alzheimer’s disease (Decock et al., 2016). APP contains a total of four GxxxG motifs.When considering that the SARS-CoV-2 spike protein is a transmembrane protein, and that it contains fiveGxxxG motifs in its sequence (see uniprot.org/uniprot/P0DTC2), it becomes extremely plausible that it could behave as a prion. One of the GxxxG sequences is present within its membrane fusion domain. Recall that the mRNA vaccines are designed with an altered sequencethat replaces two adjacent amino acids in the fusion domain with a pair of prolines. This is done intentionally in order to force the protein to remain in its open state and make it harder for it to fuse with the membrane. This seems to us like a dangerous step towards misfolding potentially leading to prion disease.A paper published by J. Bart Classen (2021) proposed that the spike protein in the mRNA vaccines could cause prion-like diseases, in part through its ability to bind to many known proteins andinduce their misfolding into potential prions. Idrees and Kumar (2021) have proposed that the spike protein’s S1 component is prone to act as a functional amyloid and form toxic aggregates. These authors wrote that S1 has the ability “to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately lead to neurodegeneration.”According to Tetz and Tetz (2020), the form of the spike protein in SARS-CoV-2 has prion regions that are not present inthe spike proteins for other coronaviruses. While this was reported in a non-peer-reviewed article, the authors had published a previous paper in 2018 identifying prion-like regions in multiple eukaryotic viruses, so they have considerable expertise in this area (Tetz and Tetz, 2018).A final point here relates to information about the Pfizer vaccine in particular. The European Medicines Agency (EMA) Public Assessment Report is a document submitted to gain approval to market the vaccine in Europe. It describes in detail a review of the manufacturing process as well as a wide range of associated testing data. One concerning revelation is the presence of “fragmented species” of RNA in the injection solution. These are RNA fragments resulting from early termination of the process of transcription from the DNA template. These fragments, if translated by the cell following injection, would generate incomplete spike proteins, again resulting in altered and unpredictable three-dimensional structure and a physiological impact that is at best neutral and at worst detrimental to cellular functioning. There were considerably more of these fragmented forms of RNA found in the commercially manufactured products than in the products used in clinical trials. The latter wereproduced via a much more tightly controlled manufacturing process.Pfizer claims the RNA fragments “likely... will not result in expressed proteins” due to their assumed rapid degradation within the cell. No data was presented to rule out protein expression, though, leaving the reviewers to comment, “These [fragmented RNA] forms are poorly characterised, and the limited data provided for protein expression do not fully address the uncertainties relating to the risk of translating proteins/peptides other thanthe intended spike protein” (EMA 2020). To our knowledge no data has been forthcoming since that time.While we are not asserting that non-spike proteins generated from fragmented RNA would be misfolded or otherwise pathological, we believe they would at least contribute to the cellular stress that promotes prion-associated conformational changes in the spike protein that is present
Here, Oxford University Press. And a place called Harvard.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.
There are spike proteins loose in the blood for some period after the jab; this is contrary to the assurances of the “Because SCIENCE!”™ crowd that the mRNA stays at the injection site and doesn’t go all over the body, and there’s no way there can be spike proteins in the blood, yada yada, because that’s what the theory behind the injections was (never mind the mice experiments in the British Medical Journal that mRNA was found in all tissues within 24 hours including crossing the blood brain barrier).
And a nice video on the effects within the body, of the spike protein, even without infection, at the layperson level with whiteboard cartoons.
Not an answer to your question, but a good description of how long the mRNA in a cell will make spike protein, based on whiteboard talks...
https://www.youtube.com/watch?v=SQztlqblgVI
The questions you raised in your post were spot on what she has been saying.
Also, she is far from the only one.