Posted on 04/23/2020 5:22:06 PM PDT by Norski
Hydroxychloroquine is one of many medications frequently used in rheumatology practice. Its remarkable versatility is attested by its routine use in lupus, in patients with an autoimmune coagulopathy, in patients with rheumatoid arthritis, as well as those with a low-level inflammatory arthropathy. It’s an amazing medication, with a novel history and wide array of indication and multiple actions that we now better understand. . .
. . .The HCQ story begins in 1638 when the wife of the Viceroy of Peru, Countess Cinchona, acquired malaria while living in the New World. Rather than getting the “approved” therapy, blood-letting, she was treated . . .
. . .I’m a clinician, not a molecular biologist, and what I want to know is: does it work and where or when? . . .
. . .The most impressive work has come from the lupus literature. . .
. . .Of equal importance, HCQ has been shown to decrease the risk of thrombosis in patients who are anti-phospholipid antibody positive..."
(Excerpt) Read more at rheumnow.com ...
Best to read the article, even if all terms are not understood. This is an extraordinary substance and derivative drug.
Also in the article:
“It appears that in patients with RA who are treated with HCQ, there is a decreased likelihood of developing diabetes compared to those who never took it.
Even more impressive, RA patients taking HCQ for more than 36 consecutive months were
70% less likely to have an incident cardiovascular event than those not taking it. . .”
Families of patients who have died in states or hospitals where they were denied chloroquine should ask some hard questions. Maybe through their lawyers.
Can I ask what is RA?
Rheumatoid Arthritis.
Thanks.
HCQ+AZ > HCQ alone.
While it demonstrated some efficacy in RA as monotherapy, HCQ has really made its name is in combination therapy. The first major publication to look at a combination therapy tested MTX+HCQ, MTX+HCQ+SSZ and MTX+SSZ in patients with established RA. While “triple” did the best, MTX+SSZ did worse than either combination using HCQ. There may be an explanation for this, coming from the Oncology literature. MTX needs to be actively transported into the cells to become polyglutamated, which is the active form of MTX. It turns out that SSZ inhibits this transport system, and this inhibition is counteracted by HCQ. Makes you think twice about using MTX+SSZ without HCQ, doesn’t it?Reminds me of the current discussion about the "triple" regimen of HCQ + Azithromycin + Zinc.
1) Open everything up and let all who will get infected catch the virus (Sweden is trying that, it's called herd immunity; it would definitely solve the SS shortfall problem looming)2) Keep everything locked down and wait until a vaccine is proven to yield immunity (and even an effective vaccine is only about sixty percent effective in yielding immunity on an individual basis; plus vaccines have scary side effects and this one coming will have a Gates data dot for everyone who gets it side effect)
3) Make a drug cocktail like HCQ + Doxycycline + zinc supplementation available (without restriction to hospitals only), so every physician and physician's assistant can write the scripts at first sign of a symptom and open the nation up to go back to being GREAT.
Since it is the human body immune system which defeats any virus that is defeated, reducing the viral load and keeping inflammation down is the best way to give the immune system a shot at developing immunity.
Hydroxychloroquine appears to have two sides to its efficacy: a) the drug has been proven as an inflammation reducer (used in RA and Lupus, and now with covid patients to reduce their airway inflammation); b) Hydroxychloroquine is a proven ionophore, ferrying ZINC into the infected cells where ZINC works to stop the viral replication thus reducing viral load.
So which of the three ways to have immunity in a society do you think the globalist oligarchy has in mind for America? And which of the three means to immunity do you think saves people and the last great hope for humanity, America?
Possibly something to consider.
And below is from another thread.
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“RE: Does the cocktail boost the immune system as well as attack and neutralize the cells infected?”
Again, all studies show that:
1. It has to be applied as soon as: a) The patient is CoVid-19 positive; and b) shows fever, coughing and/or breathing problems.
2. Do not wait till the lungs are so compromised and damaged by pneumonia and the patient needs a respirator.
If you do the above, all experience shows that the patient gets better within 5 to 6 days.
This significantly eases the burden of hospitals and healthcare workers and also reduces the death rate.
Also, Zinc is a major component of the treatment.
What many doctors observe is that the virus uses the cell as a platform to replicate. Because this invader is new, the immune system overreacts (especially true for mature individuals like the elderly) and creates what is known as a Cytokine storm, sort of like a soldier shooting at everything in sight, not differentiating between the good and bad guys, thus, killing the good as well. This causes ARDS (Acute Respiratory Distress Syndrome), where fluid collects in the lungs and air sacs depriving oxygen.
Hydroxychloroquine works in two ways:
1. Hydroxychloroquine acts as an ionophore where Zinc can work to prevent the virus from replicating.
2. Hydroxychloroquine also acts to modulate autoimmune response ( much like it does lupus ), so that the immune system’s cytokine storm calms down giving the body the chance to fight off the invader without killing its own healthy lung cells.
Azithromycin is used to fight possible bacterial infection.
These 3: HCQ+AZITHROMYCIN+ZINC, given at the right doses EARLY before the disease has the chance to progress to a more severe state is what accounts for most of the success.
ANY STUDIES THAT DO NOT TRY TO REPLICATE THE PROTOCOL AND PATIENT CRITERIA OF DR. ZELENKO will have mixed results.
Hence, this NIH sponsored study was set up to fail wheter they realize it or not. All the patients they chose to administer HCQ to were in the late stage of the disease.
It would be like administering a cancer drug when the patient is already in stage 4. There is NO GUARANTEE of a recovery at this stage.
33 posted on 4/23/2020, 4:23:29 PM by SeekAndFind (look at Michigan, it will)
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rheumatoid arthritis
“HCQ has really made its name is in combination therapy.”
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Yes. Someone posted a link to this article earlier today, and after having read it, I believed it should be posted more widely for this reason. Significant, certainly.
Just as a side note, Chaga Mushroom is also an Immune Modulator.
Clearly laid out. Thank you.
Just as a side note, Chaga Mushroom is also an Immune Modulator.”
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Yes. It is important to keep alternate possibilities in mind, especially if the supply of the most effective items is interrupted.
An example of this is Tonic Water, of which Schwepps brand is said to contain approximately 80mg of quinine per quart. Ingestion of 2.5 quarts of tonic water per day to receive the Zelenko-recommended dose of 200mg would be obnoxious, but possible.
It would be most helpful to post a list of supporting literature and/or articles to which a researcher can be immediately referred in a crisis. Also sources of the items.
Thank you, Norski
I know about it from Diana Gabaldon's Outlander series.
And that goes for anyone who has family members put in the same position.
One question, even if it seems obvious, does HCQ do anything to prevent the antibodies/immunity from developing?
I know it works best given early and with Zinc and Z-Pak.
It's also like putting motor oil in an automobile engine that's low on oil after one or more pistons have seized in their cylinders.
"Hey! Auto experts said that motor oil works to lubricate engines! THEY'RE WRONG!!!"
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