Posted on 03/25/2020 6:48:00 PM PDT by BusterDog
"Clinical course is predictable. 2-11 days after exposure (day 5 on average) flu like symptoms start. Common are fever, headache, dry cough, myalgias(back pain), nausea without vomiting, abdominal discomfort with some diarrhea, loss of smell, anorexia, fatigue.
Day 5 of symptoms- increased SOB, and bilateral viral pneumonia from direct viral damage to lung parenchyma.
Day 10- Cytokine storm leading to acute ARDS and multiorgan failure. You can literally watch it happen in a matter of hours.
81% mild symptoms, 14% severe symptoms requiring hospitalization, 5% critical."
Yeah,,,
RummyChick,
you have written much about the cytokine storm...Is that what you think is happening with these patients?**
Seems I have read something about Zithro and zinc too...
And I have elderberry, garlic, ginger, and some other things too...
~~~~~~~~~~~~~~~~~~~~~~~~~~~
***I should clarify that in another post you mentioned “viral load” and is that the same thing as the cytokine storm?
Successful therapy against Covid-19 virus from New York State:
Dr. Vladimir (Zev) Zelenko Board Certified Family Practitioner 501 Rt 208, Monroe, NY 10950 845-238-0000
March 23, 2020
To all medical professionals around the world:
My name is Dr. Zev Zelenko and I practice medicine in Monroe, NY. For the last 16 years, I have cared for approximately 75% of the adult population of Kiryas Joel, which is a very close knit community of approximately 35,000 people in which the infection spread rapidly and unchecked prior to the imposition of social distancing.
As of today my team has tested approximately 200 people from this community for Covid-19, and 65% of the results have been positive. If extrapolated to the entire community, that means more than 20,000 people are infected at the present time. Of this group, I estimate that there are 1500 patients who are in the high-risk category (i.e. >60, immunocompromised, comorbidities, etc).
Given the urgency of the situation, I developed the following treatment protocol in the pre-hospital setting and have seen only positive results:
1. Any patient with shortness of breath regardless of age is treated.
2. Any patient in the high-risk category even with just mild symptoms is treated.
3. Young, healthy and low risk patients even with symptoms are not treated (unless their circumstances change and they fall into category 1 or 2).
My out-patient treatment regimen is as follows:
1. Hydroxychloroquine 200mg twice a day for 5 days
2. Azithromycin 500mg once a day for 5 days
3. Zinc sulfate 220mg once a day for 5 days
The rationale for my treatment plan is as follows. I combined the data available from China and South Korea with the recent study published from France (sites available on request). We know that hydroxychloroquine helps Zinc enter the cell. We know that Zinc slows viral replication within the cell. Regarding the use of azithromycin, I postulate it prevents secondary bacterial infections. These three drugs are well known and usually well tolerated, hence the risk to the patient is low.
Since last Thursday, my team has treated approximately 350 patients in Kiryas Joel and another 150 patients in other areas of New York with the above regimen.
Of this group and the information provided to me by affiliated medical teams, we have had ZERO deaths, ZERO hospitalizations, and ZERO intubations. In addition, I have not heard of any negative side effects other than approximately 10% of patients with temporary nausea and diarrhea.
In sum, my urgent recommendation is to initiate treatment in the outpatient setting as soon as possible in accordance with the above. Based on my direct experience, it prevents acute respiratory distress syndrome (ARDS), prevents the need for hospitalization and saves lives.
With much respect,
Dr. Zev Zelenko
cc: President Donald J. Trump; Mr. Mark Meadows, Chief of Staff
Video at Link
8 posted on 3/24/2020, 5:02:30 PM by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
Since you are dumb...it’s hard to talk to you.
US statistics have been skewing Corona deaths as well. If you had pre-existing conditions and also were sick with Corona; Well, you died of Corona no matter you developed a secondary pneumonia infection, and had COPD.
Has sepsis met its match? New treatment may save millions around the world
Eastern Virginia Medical School Magazine ^ | 9.4 017 | Staff
Sepsis, an infection that kills millions worldwide each year and is the third leading cause of death in the United States, may have finally met its match.
Paul Marik, the EVMS Foundation Distinguished Professor in Internal Medicine, Professor of Internal Medicine and Chief of Pulmonary and Critical Care Medicine, believes he has developed a cure for the life-threatening infection. His treatment breakthrough promises to revolutionize sepsis care and produce results that are nothing short of astonishing.
Vitamin C is often used intravenously as part of a treatment for cancer.
Hydrocortisone is used to relieve inflammation and for a variety of conditions from arthritis to asthma.
Thiamine is a vitamin.
Sepsis is the leading cause of death among hospitalized patients.
As a critical-care physician and head of the general intensive care unit (GICU) at Sentara Norfolk General Hospital, Dr. Marik used to be locked in a struggle with sepsis. Despite his efforts, one to two people under his care died each week from the disease. That all changed unexpectedly Jan. 5, 2016.
The breakthrough came as Dr. Marik struggled to save a woman dying from overwhelming sepsis. He had recently read about vitamin C as a potential treatment for sepsis, and he recalled that steroids, a common treatment for sepsis, might work well in concert with the vitamin C.
Aware that both were safe and would not harm the patient, he gave her the vitamin C and steroid combination intravenously.
Within hours, his patient was recovering. Two days later she was well enough to leave the ICU.
Dr. Marik and is colleagues were astonished.
In the following days they used the combination therapy on two more patients seemingly destined to die of sepsis. Twice more the patients recovered. Dr. Marik and his team quickly adopted the combination therapy as standard practice.
(Excerpt) Read more at evms.edu ...
Here is his protocol:
Dosing Strategy PDF:
https://www.evms.edu/uploads/magazine/9-4/downloads/Dosing_strategy.pdf
1 | Page Vitamin C, Hydrocortisone and Thiamine For the treatment of Severe Sepsis and Septic ShockVitamin C, Hydrocortisone and Thiamine dosing protocol
Vitamin C: 1.5 g IV q 6 hourly for 4 days or until discharge from the ICU.
Hydrocortisone: 50mg IV q 6 hourly for 4 days or until discharge from the ICU. Taper is not required.
Thiamine: 200mg IV q 12 hourly for 4 days or until discharge from the ICU.
Alternative dosing: 100mg IV q 6 hourly for 4 days. Vitamin C: Vitamin C is provided by the manufacturer as a 50 ml vial at a concentration of 500mg/ml.
Three (3) ml of vitamin C will be placed in a 100ml bag of either dextrose 5% in water (D5W) or normal saline and infused over 30-60 minutes. The Vitamin C min-bag solution is stable for in excess of 24 hours (should be protected from light).
Hydrocortisone:Hydrocortisone 50 mg bolus q 6 hourly
Thiamine: Intravenous thiamine (200 mg) is placed in a piggyback in 50 ml of either D5W or normal saline and administered as a 30-minute infusion.
NOTE: The Vitamin C and Thiamine can both be mixed in the same mini-bag
Or just an internet moron?
A few hours ago, I had to call the paramedics on my mom in Dallas.
She has a fever and she fell. I couldn’t get a hold of family or friends that live near here.
My sister-in-law got over there when the paramedics were there. They told her that they didn’t think it was Corona virus, but they told her not to take my mom to the ER because it is a 5 hour wait. They said to contact her doctor.
So I think it’s bad in Dallas.
Thank you for the excellent article. It provided a complete and satisfying answer to my question and I am grateful.
Kudos for an extremely informative post filled with factual matrial.
My biggest takeaway was the reporting that 70% of Seattle patients on respirators die. They don’t recover. That is horrific.
I am not a medical expert, so some details I had to look up and some are still lost on me.
I now ignore studies which rely on foreign statistics.
Wait a minute here! As of this morning, we only have about 5500 confirmed cases in the US and only about 850 deaths nationwide. (Plus Almost 200 recoveries!)
... and this doctor is saying his local associates have seen “several hundred cases” each?!?!? Doesn’t add up. All of LA only has about 1300 cases.
Are my numbers wrong?
A U.S. State! Hadn’t thought of that. Thanks, ark.
“So anyone who has psoriasis and not on medication could be at higher risk”
I don’t see how. The massive reaction that Covid can trigger wouldn’t have any actual connection to the cytokine issues affecting your skin.
https://www.psoriasis.org/advance/coronavirus
I remember a patient who got a look at his chart and saw SOB on it and though we were calling him a sonofabitch..lol
The hospital IT also would abbreviate religious affiliation in a somewhat humorous way i.e. “Assembly of God” was shortened to AssofGod...yikes
That’s quite some doctor-ese in there.
Could someone translate into English (MomMD)? (If it’s not too much work?)
Thanks!
That’s a big help.
Inflammation associated with a cytokine storm begins at a local site and spreads throughout the body via the systemic circulation. Rubor (redness), tumor (swelling or edema), calor (heat), dolor (pain), and “functio laesa” (loss of function) are the hallmarks of acute inflammation. When localized in skin or other tissue, these responses increase blood flow, enable vascular leukocytes and plasma proteins to reach extravascular sites of injury, increase local temperatures (which is advantageous for host defense against bacterial infections), and generate pain, thereby warning the host of the local responses. These responses often occur at the expense of local organ function, particularly when tissue edema causes a rise in extravascular pressures and a reduction in tissue perfusion. Compensatory repair processes are initiated soon after inflammation begins, and in many cases the repair process completely restores tissue and organ function. When severe inflammation or the primary etiological agent triggering inflammation damages local tissue structures, healing occurs with fibrosis, which can result in persistent organ dysfunction.
Acute lung injury (ALI) is a common consequence of a cytokine storm in the lung alveolar environment and systemic circulation and is most commonly associated with suspected or proven infections in the lungs or other organs (121). In humans, ALI is characterized by an acute mononuclear/neutrophilic inflammatory response followed by a chronic fibroproliferative phase marked by progressive collagen deposition in the lung (Fig. 2) (reviewed in reference 96). Pathogen-induced lung injury can progress into ALI or its more severe form, acute respiratory distress syndrome (ARDS), as seen with SARS-CoV and influenza virus infections. IL-1β is a key cytokine driving proinflammatory activity in bronchoalveolar lavage fluid of patients with lung injury (118). Intense inflammation in the lungs also can have other systemic effects on other organs, as the combination of severe HCl injury in the lungs and mechanical ventilation in rabbits leads to renal dysfunction and evidence of apoptosis in renal tubular epithelial cells (69).
You’re chastising the wrong person.
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