Posted on 01/31/2020 10:32:38 AM PST by winoneforthegipper
Abstract We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus
Higher? Interesting.
I’d think lower death rate would mean lower affinity.
But it is a complex question that involves more just binding affinity.
True.
If it were just one insertion in the spike protein I’d be less likely to believe it weren’t natural.
2 insertions, still...but spidey sense activated...
3, now you’re cooking with gas...
4?!. odds are teeny.
combined with the fact that wuhan has a bl4 lab?
ya. like my kiddo telling me once she had no idea what happened to the chocolate chips...while covered with chocolate.
We can not trust the death rate published.
No.
Polymorphism so like this are normal.
Compare any proteins and this sort of thing crops up.
Most are silent.
Are you considering recombination in a lab could account for it?
Bkmrk
Exactly!
the only thing missing are dogs and goats
https://news.yahoo.com/h5n6-bird-flu-hits-swans-085441106.html
Very helpful thanks.
4 places at once?
rilly?
and all make for a gain of function mutant?
With all this other HIV stuff I’m wondering if these insertions give any sort of cross binding reactivity.
Well, there has to be a bit of gallows humor...and that one is spot-on!
That said, this really is no laughing matter - I hope and pray for the spread to be stopped ASAP, and for everyone infected to be cured quickly...even as I know that such will not be happening.
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