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Gene-edited cattle have a major screwup in their DNA
technology review ^ | Aug 29, 2019 | ALISON VAN EENENNAAM

Posted on 09/09/2019 10:51:37 AM PDT by Mount Athos

Food and Drug Administration scientists who had a closer look at the genome sequence of one of the edited animals, a bull named Buri, have discovered its genome contains a stretch of bacterial DNA including a gene conferring antibiotic resistance.

The “unintended” addition of DNA from a different species occurred during the gene-editing process itself, the government says. It went undetected by the company even as it touted the animals as 100% bovine and assailed the FDA for saying the animals needed to be regulated at all.

“It was not something expected, and we didn’t look for it” says Tad Sontesgard, CEO of Acceligen, a subsidiary of Recombinetics that owns the animals. He says a more complete check “should have been done.”

“We know exactly where the gene should go, and we put it in its exact location,” Recombinetics executives told Bloomberg in 2017. “We have all the scientific data that proves that there are no off-target effects.”

Van Eenennaam says since the FDA discovery, UC Davis has incinerated three of the five males who were living at its farms. The animal who posed for the cover of Wired is pregnant and will be spared for the time being.

(Excerpt) Read more at technologyreview.com ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: alteredcattle; cattle; dna; geneediting
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To: DannyTN

That’s true.

And scary :)

We humans love to think we’re incredibly individual, and we are, but there’s few things that cross our minds that NO ONE has ever thought of before.


41 posted on 09/09/2019 11:38:11 AM PDT by dp0622 (Bad, bad company Till the day I die.)
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To: null and void

We’ve all worked with people who are total screw-ups.

When a total screw-up works in an accounting office or a gravel pit or a body shop it’s one thing.

When they are running a nuke plant or splicing genes together its something altogether different.


42 posted on 09/09/2019 11:41:29 AM PDT by Buckeye McFrog (Patrick Henry would have been an anti-vaxxer.)
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To: pepsi_junkie
So they created a mutant cow that has genes that make it resistant to antibiotics.

I was never aware that antibiotics worked on cows ... I thought they worked on bacteria.

43 posted on 09/09/2019 11:42:13 AM PDT by Mr Ramsbotham ("God is a spirit, and man His means of walking on the earth.")
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To: Buckeye McFrog

“When I say we aren’t smart enough to play God, I really mean it.”

Yep, I’ve been telling the GMO people for years. Just because we can do something right and prove it in a lab, doesn’t mean it will always be done right. People screw up even the most serious things daily.

A screwup when engineering a building can lead to one building falling and would not alter the planet. But a screwup in altering life that naturally multiplies and wants to live is asking for serious trouble.


44 posted on 09/09/2019 11:51:04 AM PDT by varyouga
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To: Mount Athos

Coulda, shoulda, didn’t. What a surprise!


45 posted on 09/09/2019 11:51:56 AM PDT by Flaming Conservative ((Pray without ceasing))
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To: Veto!

LOL!

What colossal ignorance of how beef is raised.


46 posted on 09/09/2019 11:58:19 AM PDT by Balding_Eagle ( The Great Wall of Trump ---- 100% sealing of the border. Coming soon.)
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To: Veto!

Our favorite butcher shop raises their own cattle. They’re rather pricey, but not “grass fed” nonsense, so we usually only buy hamburger from them. But at least they don’t put mystery meat in their hamburger. I think I’ll run up the idea to our tiny congregation of raising a couple of head of cattle. (Not as a church, just as individuals within the church). Of course, we’d have to be sure of the calves we’d buy. Lots of small time cattle raising around here, tho.


47 posted on 09/09/2019 12:01:43 PM PDT by Flaming Conservative ((Pray without ceasing))
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To: dfwgator

I used to buy almost no supermarket meat, but I have to economize, so I buy what’s on sale. Except hamburger. I may occasionally buy ground chuck on sale somewhere, but not regular hamburger. They’ll grind up anything in that stuff. Remember pink slime?


48 posted on 09/09/2019 12:07:52 PM PDT by Flaming Conservative ((Pray without ceasing))
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To: Celtic Conservative

At least with animals there is only so much “editing” which can be done before it’s fatal. I always question that with plants.. one reason I am a carnivore deluxe.


49 posted on 09/09/2019 12:12:44 PM PDT by momincombatboots (Ephesians 6... who you are really at war with)
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To: Mount Athos

And this will happen to gene edited babies, where there are unintended consequences.


50 posted on 09/09/2019 12:20:28 PM PDT by Crucial
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To: pepsi_junkie

So they created a mutant cow that has genes that make it resistant to antibiotics.


I remember a silly tune called “Mutant Cows” that they used to play on the Dr. Demento Show back in the 90’s. I could not find it on YT.


51 posted on 09/09/2019 12:46:19 PM PDT by AlexisHeavyMetal1981 (Z)
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To: Mount Athos

“It was not something expected, and we didn’t look for it” says Tad Sontesgard, CEO of Acceligen”

What a moron.

FDA in things like this is quite competent. They knew something like this is possible and easy to check for.

The company’s scientists easily could have found it and known look for it.

This company needs new leadership.

Having said all that, inclusion of a stretch of bacterial DNA is most likely safe ans has no effect.


52 posted on 09/09/2019 12:55:47 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: Mr Ramsbotham

Good catch.

Poor writing is so common.


53 posted on 09/09/2019 1:03:24 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: Flaming Conservative

Great idea. My daughter lives out in the country, bought a side of beef from local guy down the road. It was TERRIBLE. So whatever you do, do it right....whatever right is.


54 posted on 09/09/2019 1:04:40 PM PDT by Veto! (Political Correctness Offends Me)
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To: Buckeye McFrog

We’re never as smart as we think we are. That’s why we always go and play with fire. Then the fire burns us and we act surprised.


55 posted on 09/09/2019 1:35:58 PM PDT by Crucial
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To: Mount Athos

This is why — what we don’t raise ourselves, we buy locally.


56 posted on 09/09/2019 2:00:23 PM PDT by Cloverfarm (Pray for the peace of Jerusalem ...)
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To: Mr. K

#8. Re “What other species did they merge it with”? It was the “Hildabeast” of the Clinton bovine family.

Nothing but horns, a bad temperament, farts all the time, and tastes like shit.

When served as a “Hildaburger”, no waiter asks, “You want fries with that”? They ask, “You want a barf bag with that?”


57 posted on 09/09/2019 9:15:30 PM PDT by MadMax, the Grinning Reaper
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To: cuban leaf

#14. Re “I sure wouldn’t want to cross paths with a Pitt bull with the personality of a Chihuahua.”

I guess you’ve never met Nancy Pelosi!


58 posted on 09/09/2019 9:17:14 PM PDT by MadMax, the Grinning Reaper
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To: MadMax, the Grinning Reaper

Lol! I had to laugh thinking of what you said reminded me of Sarah Jessica Parker’s head on the body of a chihuahua in “Mars Attacks!”


59 posted on 09/09/2019 9:36:33 PM PDT by Rainwave ("Work out your OWN salvation with fear and trembling")
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To: Buckeye McFrog
Only God can play God and get away with it.
60 posted on 09/10/2019 2:08:29 PM PDT by JoeFromSidney (Colonel (Retired) USAF.)
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