Posted on 08/22/2015 9:21:12 AM PDT by Tired of Taxes
At a press conference today, former President Jimmy Carter revealed the ways he is tackling the melanoma cancer that has spread to his brain and liver: He'll receive radiation, as well as another lesser-known treatment called immunotherapy.
Up until now, most cancer patients only had a few options. They could get chemotherapy or radiation that kills cancerous cells and stops them from dividing, or surgery to cut out the disease. Yet the success rate of these options is far from perfect.
Now a new kind of cancer treatment has come into play: immunotherapies. These treatments, which include Carter's infusion called pembrolizumab, try to stimulate the immune system, often through artificial proteins or vaccines, to help the body attack cancer from within.
The positive outcomes for some patients receiving immunotherapy seem extremely impressive. Doctors have seen deadly tumors disappear, and patients who were supposed to die have gone into remission for years. Such prolonged responses to treatment in very sick patients are almost never seen with chemotherapy.
Drug companies are jumping into the fray to bring new immunotherapies to market. As the Wall Street Journal reported, half of Standard & Poor’s top 10 list of promising drugs for 2015 included cancer immunotherapies. In the bleak landscape for cancer treatment, the news is inspiring.
"These latest immunotherapy drugs," Carter said, "whether alone or in combination with other treatments, seem to be the future of cancer therapy."
But is immunotherapy the holy grail scientists have been searching for, or just the latest in a long line of overhyped cancer fixes that flopped? Here's how doctors think about these drugs.
The idea behind immunotherapy is at least a century old
In the 1890s, a New York surgeon named William Coley noted that a patient's cancer seemed to vanish after he came down with a bacterial infection. Coley thought maybe the bacteria had activated his immune system to fight the cancer.
He wasn't alone. Before him, other doctors had also noted the weird link between infections and spontaneous cancer remissions. So Coley started experimenting by injecting people's tumors with bacteria. He found that the cancer regressed in some of those patients.
While Coley is now regarded as the "father of immunotherapy," his peers simply didn't believe his results. The idea of immunotherapy for cancer fell in and out of favor over the next 100 years, particularly as doctors were having success with radiation and chemo.
Immunotherapy can stop cancer — but it occasionally causes serious problems
Flash forward to 1992, when the first immunotherapy for cancer came on the market. Interleukin-2 (IL-2) was approved by the Food and Drug Administration to treat metastatic renal cell carcinoma, an advanced form of kidney cancer, and, a few years later, to treat advanced melanoma (a deadly skin cancer).
When patients took large doses of IL-2 — a protein that's made during an immune response — their bodies sometimes attacked cancer cells, and the drug appeared to save lives. Mark Gorman, the first patient who got the treatment, survived a cancer that should have killed him within months.
But IL-2 treatment hasn't been completely positive. "Despite its potential for miracles, IL-2 produces complete remission in only around 6 percent of people with melanoma. The treatment kills as many as 2 percent of recipients," a 2014 Nature review on the state of immunotherapy notes.
The therapies work wonders for some — but can kill in rare cases
That seems to be a consistent pattern. Doctors have found that immunotherapies can work wonders in a minority of patients with particular cancers. But they often don't work at all in other patients, and can even send some patients' immune systems into overdrive, causing autoimmune disorders that attack healthy cells. In very rare cases, these treatments can kill.
As Heidi Ledford, the author of the Nature review, states, "After that 1992 approval, researchers and pharmaceutical companies spent years trying to develop new immunotherapies that could produce success stories like Gorman's [the IL-2 patient]. But those attempts failed to live up to their promise in the clinic, leading to decades of frustration."
There are several new immunotherapies now on the market
Right now, many different kinds of immunotherapies for a variety of cancers are in testing. These include treatments that use engineered viruses — HIV, measles, smallpox — to reprogram cells to destroy cancer. (The Vice documentary focuses only on these.) There are also therapeutic cancer vaccines and drugs that get T-cells, the soldiers of the immune system, to work harder to attack cancer.
The types of immunotherapy that appear to be most promising at the moment — the ones that really have the medical community excited — are called "checkpoint inhibitors."
"T-cells are tightly regulated with 'turn on' and 'turn off' signals," explained Dr. Michael Postow, an oncologist who is researching immunotherapies at Memorial Sloan Kettering. Checkpoint proteins do the work of turning them on or off. Checkpoint inhibitors block the body's checkpoint proteins, freeing them to attack cancer.
Even checkpoint inhibitors only work on a fraction of patients, and no one really knows why
One of the first approved checkpoint inhibitors was ipilimumab (brand name Yervoy), an infusion that came to market in 2011 and targets a checkpoint protein called CTLA-4. Ipilimumab was also the first drug to extend the overall survival of patients with advanced melanoma.
The average survival rate for patients on the drug was about 10 months (four months more than those who got a cancer vaccine) — but some people had responses lasting years and counting. Again, however, using the body's immune system to fight cancer isn't always safe: The drug causes severe autoimmune side effects in about 15 percent of patients, and 2 percent (14 people) died as a result of the treatment.
Using the body's immune system isn't always safe
Since 2011, two other drugs have also been approved — nivolumab and pembrolizumab (Carter's medicine) — which target a different molecule, PD-1. These drugs treat advanced melanoma, and nivolumab was also approved for lung cancer.
Drugs targeting the PD-1 pathway have shown responses in a variety of cancers such as melanoma, lung cancer, kidney cancers, bladder cancers, and Hodgkin lymphoma. There are now dozens of clinical trials to test this and other kinds of checkpoint inhibitors for dozens of cancer types.
So these drugs also have promising, but nowhere near perfect, profiles. Take, for example, nivolumab, the checkpoint inhibitor approved for lung cancer. Because the science is new, the long-term data isn't in yet. But so far, researchers found two main effects: Some 15 percent of people saw their cancer shrink away or disappear, and about half of the people who had that response found that it lasted for at least six months.
"Although the fraction of people who respond to these agents is small, the durability of responses when they occur represents a substantial step forward," said Dr. Matthew Hellmann, another Memorial Sloan Kettering oncologist and researcher.
As for side effects, he explained, "The most common experience was that patients feel well. But there can be uncommon side effects, where the immune system attacks other parts of the body — like the thyroid gland — that it shouldn't. In those cases, patients have to be treated with steroids, and some, very rarely, have died."
He continued: "When we talk about using the body’s immune system against cancer, there’s a perception that it is natural and safe." But that isn't always the case.
Research that was recently presented at the American Society of Clinical Oncology meeting in Chicago told a similar story. The New England Journal of Medicine study showed that a combination of two immunotherapies — ipilimumab and nivolumab — and nivolumab alone helped melanoma patients live longer than treatment with ipilimumab only. But a majority of patients (95 percent in the combination group and about 82 percent in the nivolumab group) experienced intense side effects (colitis, diarrhea, and fatigue). Some were so severe, the patients had to discontinue treatment.
Dr. Hellmann has been looking into, among other things, why immunotherapy works better in some patients than in others. He has found that for some immunotherapies, patients who had the most heavily mutated tumors responded best.
This insight has left the field with big questions, including: why do these therapies save some lives and not others? "The critical challenge that we have in the scientific community," said Hellmann, "is to figure out who are the patients most likely to benefit from these treatments and how can we develop better treatments to help those patients less likely to benefit from current immunotherapies."
We're not at the precipice of a "cure"
All the doctors I spoke to were really optimistic about immunotherapies, but had several big caveats.
The dramatic progress has been the simple fact that these drugs work for some periods of time in some patients. And one of the major challenges is to understand why, and who will benefit.
As Dr. Hellmann put it, "I think this is true promise." He pointed to the activity in melanoma research and the three drugs now available to patients. But he also said, "About 15 to 20 percent really benefit from the medicines. It's remarkable — in that the benefit, when it occurs, tends to occur for a long time, but the challenge for us is how you identify those 15 to 20 percent.
"This is the beginning of a really important story," he summed up.
Dr. Padmanee Sharma, a physician-researcher at MD Anderson in Houston, Texas, encouraged patients who are interested to seek out experimental immunotherapies on databases such as clinicaltrials.gov. She said she's never seen anything like the effects immunotherapies are having, but added that it's also very early days, and doctors still need to experiment with combination therapies to find out whether they'd be more effective.
Memorial Sloan Kettering's Dr. Postow said for all the buzz about these drugs right now, there's a lot to be learned: "As excited as we are about this field, we know it doesn't help every patient, and we’re still trying to figure out who it helps, how it helps, and why." He continued: "It’s important for doctors and patients to realize this is not chemo."
I recommend death therapy.
Did his doctors have an end of life discussion with him?
There was a facebook posting about that - the irony. Yes, maybe he should...um, boycott it?
Where are you being treated?
I have metastatic prostate cancer and am being treated at MD Anderson in Houston. Forunately Lupton is keeping things in check with my PSA having gone from 14.7 a year ago to 0.4 for the last 6 months.
Was at a seminar last month at MD Anderson and they believe a cure for metastatic prostate cancer will be based on immunotherapy or viral therapy. Actually talking about an eventual cure.
I wonder why Obama and Obamacare didn’t send Jimmy home with just a bunch of pain pills???? That is what the rest of us would have gotten, if that. With all of this that is going on with the horrific Planned Parenthood and the aborted babies, I can’t help but wonder how far away our government is to just killing off old sick people.
MD Anderson has an excellent reputation.
Jeff Head went there.
Is Jimmy on TriCare?
There has very recently been a modified cold irus that triggers the body’s natural immune system that has actually attacked and completely destroyed one for of rare brain cancer.
MD Anderson is the best cancer center in the world. If not for MD Anderson, Jeff Head would have been dead years ago.
Radiation doesnt work against most cancers.
Remember asshat barrys line to the gal with the older mom?
Maybe we just give her the pain pill.
I’m the Cicero2K here as well:
http://www.healingwell.com/community/default.aspx?f=35
Lots of MD Anderson guys there as well.
I’m 12 years in, went metastatic last year, but in a nearby lymph node. The newer imaging technology allows for pin point radiation of much higher intensity. It’s all there. I’m being treated in LA, and going to the PCRI conference in September.
Jimmy makes me sick. He’ll get the best treatment money can buy while the poor and middle class get the shaft.
I did a lot of translation of documents concerning Anti pd-1 antibodies and it really is the treatment of the future.
I hope so, Struggle. Looking forward to it.
” another lesser-known treatment”
Because the ruling class should have access to treatments that the proles shouldn’t.
I am a cancer patient. I had surgery plus chemo plus immunotherapy. My cancer has been in remission for seven years.
bottom line......toast
Great news, Ought-six. :-)
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