Cancer protection secret revealed ( how cells switch a gene called p53,)

BBC ^ | 00:01 GMT, Sunday, 1 February 2009 | BBC Staff

[Ernest_at_the_Beach]

Scientists say they have discovered a missing link in the way cells protect themselves against cancer.

Zebrafish share the p53 gene with humans

They have uncovered how cells switch a gene called p53, which can block the development of tumours, on and off.

The researchers say the finding has important implications for cancer treatment and diagnosis.

The study, published in Genes And Development, was carried out by teams of scientists in Singapore and the University of Dundee.

	Discovering how it is regulated will have incredibly important implications in the development of better drugs and ways to diagnose cancer Lesley Walker Cancer Research UK

The p53 gene, first discovered 30 years ago, plays a vital role in keeping the body healthy by ordering damaged cells to commit suicide, or by stopping them dividing while key repair work is carried out.

In half of all cancers the gene is either damaged or inactive, giving damaged cells a free rein to keep dividing and form cancer.

In the latest study, the scientists used a genetic trick to make zebrafish turn green when the p53 gene was switched on to explore the way it was regulated.

[SouthTexas]

Not mine. We don’t eat bait.