Posted on 08/20/2007 1:44:54 PM PDT by Responsibility2nd
CHICAGO (Reuters) - A common virus caused human adult stem cells to turn into fat cells and could explain why some people become obese, U.S. researchers said on Monday.
The research builds on prior studies of adenovirus-36 -- a common cause of respiratory and eye infections -- and it may lead to an obesity vaccine, they said.
"We're not talking about preventing all types of obesity, but if it is caused by this virus in humans, we want a vaccine to prevent this," said Nikhil Dhurandhar, an associate professor at Pennington Biomedical Research Center at Louisiana State University System.
The virus adenovirus-36 or Ad-36, caused animals to pack on the pounds in lab experiments. "These animals accumulated a lot of fat," Dhurandhar said in a telephone interview.
Dhurandhar also has shown that obese people were three times more likely to have been infected with Ad-36 than thin people in a large study of humans.
Now, researchers in Dhurandhar's lab have shown that exposure to the virus caused adult human stem cells to turn into fat-storing cells.
Dr. Magdalena Pasarica, who led the study, obtained adult stem cells from fat tissue of people who had undergone liposuction. Stem cells are a type of master cell that exist in an immature form and give rise to more specialized cells.
Half of the stem cells were exposed to the virus Ad-36. After a week, most of the infected stem cells developed into fat cells, while the uninfected cells were unchanged.
Pasarica presented her findings at a meeting of the American Chemical Society in Boston.
"The virus appears to change their commitment to a fat storing cell," Dhurandhar said, adding that Ad-36 is just one of 10 pathogens linked to obesity and that more may be out there.
He acknowledged that some people might find it hard to believe that a virus could be responsible for obesity.
"Certainly overeating has something to do with gaining weight. No doubt about that. But that is not the whole truth," Dhurandhar said. "There are multiple causes of obesity. They range from simple overeating to genes to metabolism and perhaps viruses and infections."
Long term, he said he hoped to develop a vaccine and perhaps treatments for the virus. But first, he and colleagues need to better understand the role of Ad-36 in human obesity, he said.
Globally, around 400 million people are obese, including 20 million children under age 5, according to the World Health Organization.
It’s more likely an effect rather than a cause. A fat persons body is highly acidic, full of candida and yeast, and low in oxygen, this is the perfect environment for such stuff to exist.
wow...that is a ton of stress...glad to hear you are doing better now.....thanks again for all the info...I’ve passed it on to her
super info..thanks for the follow-up!
Thanks for the link....we will have to give this a try...
You can get a quick preview from Schwarzbein's website here.
Yeah thanks. Much better. My sypmtoms that sent me to the doc were not weight (although I was POed about that) Mine was brain fog, no memory, not being able to stay focused, NO sex drive (and this was a biggie for me) I really thought I was getting alzheimers. Went to the doc two years ago for the symptoms, she gave me zoloft. All that did was help my sleep and add some pounds. Gave it up after a year. This year, after getting progressively worse on the brain stuff, went back to her and be damned if she didn’t want to give me zoloft again. Got really close to my face and said that my symptoms were also hormonal/menopausal something I went through 7 years before so I KNEW what that was. It realy pissed me off for her to say that - like I don’t know what is going on with my own body. Anyway, after tests results and a scan of my thyroid, why, yes I do have a problem. I wasn’t depressed but after going to the doc I was getting that way. LOLL After a bunch of that stuff happened, we joked that we would have been alcolohics but couldn’t afford the likker LOLL
That may be so but Id like to know how you know that.
Check out Robert Ardrey’s book titled African Genesis.
Hunting is not that easy. Try it sometime and youll see what I mean.
I hunt. My first gun (besides the usual .22 was a .300 Wby built by Jesse Harpe’s gunsmith Herb back in the mists of time when I was in the 9th grade.
Also, their tools were primitive.
So is a bow.
And they didnt live long either, so if they did eat that kind of diet, maybe thats another reason they all kicked off so young.
Whacking lions and leopards on the head is inherently risky.
Also, if this is true, I dont really care what prehistoric man ate. Id like to keep at least within the past few hundred years for sanitys sake.
Consider how much genetic change can occur and become widespread amongst humans in a mere few hundred years.
I actually agree. Obesity is hard on the body.
I think the biggest hurdle for people trying to lose weight (and/or just stay healthy) is that we don't really know how to eat well anymore. A lot of the products on the shelf are little more than processed junk and that includes some or even most of what's being passed off as health food. Also, people tend to forget that not all calories are the same. There's something to be said for the nutritional content, or lack thereof, in any given product. But I think good nutrition is far more complicated than what gets printed on the side of a box.
Ironically, the processed food industry was born (at least partly) out of a concern for healthy eating. Working women needed a way to feed their kids something decent. Obviously, they didn't have a lot of time left to spend in the kitchen. Processed food was the solution. This has become a very large industry. But somewhere along the way it's become more about money and less about health, as evidenced by all the trash being marketed as food.
Yep, we’ve got to keep watching out for stuff that hit our families, which is cancer for mine. Good idea to keep watching that bowel, and colon. Your wife’s grandmother probably got thinner because she ate so little. They probably had to fight to get her to eat. That isn’t life. It is existing.
Take care.
You'll note that this one is described as "adenovirus-36 -- a common cause of respiratory and eye infections". Sounds like a cold or flu virus to me. But what do I know, so I checked the CDC website and found this:
Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis.
Treatment: Most infections are mild and require no therapy or only symptomatic treatment. Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection.
Prevention: Vaccines were developed for adenovirus serotypes 4 and 7, but were available only for preventing ARD among military recruits. Strict attention to good infection-control practices is effective for stopping nosocomial outbreaks of adenovirus-associated disease, such as epidemic keratoconjunctivitis. Maintaining adequate levels of chlorination is necessary for preventing swimming pool-associated outbreaks of adenovirus conjunctivitis
Well, that's probably true, but she never got all that thin, just thinner. I think she just forgot to eat, like she forgot to change her clothes, do her housework (she had been fastidious in both areas) and eventually forgot to recognize her family, even including her husband.
That is sooo sad. I’m sorry for you, your family, and your grandmother.
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