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You Are What Your Grandmother Ate
New Scientist ^ | 11-13-2006 | Roxanne Khamsi

Posted on 11/13/2006 3:06:19 PM PST by blam

You are what your grandmother ate 22:00 13 November 2006
NewScientist.com news service
Roxanne Khamsi

The mice on the left-hand side have active AVY genes, giving them golden fur, while those on the right have silenced AVY genes (Image: Cropley et al/PNAS)

A mother’s diet can change the behaviour of a specific gene for at least two subsequent generations, a new study demonstrates for the first time.

Feeding mice an enriched diet during pregnancy silenced a gene for light fur in their pups. And even though these pups ate a standard, un-enriched diet, the gene remained less active in their subsequent offspring.

The findings could help explain the curious results from recent studies of human populations – including one showing that the grandchildren of well-fed Swedes had a greater risk of diabetes.

The new mouse experiment lends support to the idea that we inherit not only our genes from our parents, but also a set of instructions that tell the genes when to become active. These instructions appear to be passed on through “epigenetic” changes to DNA – genes can be activated or silenced according to the chemical groups that are added onto them.

Gene silencer

David Martin at the Children’s Hospital Oakland Research Institute in California, US, and colleagues used a special strain of genetically identical mice with an overactive version of a gene that influences fur colour. Mice with the AVY version of this gene generally have golden fur.

(Excerpt) Read more at newscientist.com ...


TOPICS: News/Current Events
KEYWORDS: dna; genes; grandmother; offspring
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To: blam
My mother's mother was 100% kraut, via Ohio. She ate, mostly, limberger and onion sandwiches on rye bread, Pabst Blue Ribbon and something called "German Lettuce" which involved wilting lettuce in bacon grease and mayonaise.

There was also a great deal of fried fish, saur kraut and knockwurst, and lots of pie, lemon meringue mostly.

21 posted on 11/13/2006 3:44:30 PM PST by RepoGirl ("Tom, I'm getting dead from you, but I'm not getting Un-dead..." -- Frasier Crane)
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To: EggsAckley

I must be lox and bagels and kugel


22 posted on 11/13/2006 3:48:32 PM PST by Hildy (RUDY GUILIANI FOR PRESIDENT IN 2008)
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To: EggsAckley

OHH and CHICKEN FAT...which does explain alot!


23 posted on 11/13/2006 3:49:00 PM PST by Hildy (RUDY GUILIANI FOR PRESIDENT IN 2008)
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To: Hildy

Yes indeed. There's NO such thing as TOO MUCH chicken fat.

~/<;o)


24 posted on 11/13/2006 3:50:42 PM PST by EggsAckley
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To: theFIRMbss

Monica Lewinsky's kids are destined to be great swimmers.


25 posted on 11/13/2006 3:52:18 PM PST by andy58-in-nh
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To: blam

Well, one grandmother died of heart disease and one has Type II diabetes. Ruh roh!

They consumed a George McGovern diet: plenty of hydrogenated oils (margarine was so preferable to butter, you know), corn, white bread, and pasta.


26 posted on 11/13/2006 3:52:31 PM PST by agrarianlady
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To: beaversmom

I was hamburgers, especially when I was pregnant.


27 posted on 11/13/2006 3:57:10 PM PST by tiki
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To: blam
I have always contended that the most important decision you make in life is who you chose to be your grandparents.

'Soul' (Redneck Southern)food is what I had three times a day for the first twelve years of my life. All four grandparents lived into their late eighties to mid nineties when the average life expectancy was 55.

My wife has a similar heritage...

our diet is still fatty and flavorful and the only time we visit a doctor is for a checkup... We also have never had a prescription that was renewed more than twice...

BTW, I am 70 and my wife is 65...
28 posted on 11/13/2006 3:59:02 PM PST by CenTex (No longer a Republican, but still a Conservative...)
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To: andy58-in-nh
Monica Lewinsky's kids are destined to be great swimmers.

And truly great LIARS!

29 posted on 11/13/2006 3:59:59 PM PST by Randy Larsen (Vote For Our Survival!)
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To: GSlob

why stop at Michurin when Lysenko is just around the corner?


30 posted on 11/13/2006 4:01:10 PM PST by chilepepper (The map is not the territory -- Alfred Korzybski)
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To: blam

It's all Grandma's Fault!


31 posted on 11/13/2006 4:01:49 PM PST by celtic gal
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To: blam

Blam you are busy these days!


32 posted on 11/13/2006 4:34:45 PM PST by Pete from Shawnee Mission
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To: A. Pole

--Some day Lamarck will be rehabilitated, mark my words.--

"Nature, in producing in succession every species of animal, and beginning with the least perfect or simplest to end her work with the most perfect, has gradually complicated their structure."


33 posted on 11/13/2006 4:41:36 PM PST by UpAllNight
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To: A. Pole

PUKS. If you haven't read Voinovich, read him.


34 posted on 11/13/2006 4:43:15 PM PST by GSlob
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To: chilepepper
'why stop at Michurin when Lysenko is just around the corner?"
I was trying to be polite - this is supposed to be a family-friendly forum, after all.
35 posted on 11/13/2006 4:44:57 PM PST by GSlob
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To: blam
You Are What Your Grandmother Ate

Wow! I really am my own Grandpa!

Oh. Did I just say that?

36 posted on 11/13/2006 4:46:06 PM PST by uglybiker (Don't look at me. I didn't make you stupid.)
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To: blam

My Mother's family is from South Texas, and I'm sure ate a lot of Mexican food. What does that portend for my descendants?


37 posted on 11/13/2006 4:48:42 PM PST by GeorgefromGeorgia
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To: A. Pole

--Some day Lamarck will be rehabilitated, mark my words.--

"The theory that Lamarck published consisted of several components. Underlying the whole was a 'tendency to progression', a principle that Creation is in a constant state of advancement. It was an innate quality of nature that organisms constantly 'improved' by successive generation, too slowly to be perceived but observable in the fossil record. Mankind sat at the top of this chain of progression, having passed through all the previous stages in prehistory."


38 posted on 11/13/2006 4:54:22 PM PST by UpAllNight
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To: GSlob
PUKS. If you haven't read Voinovich, read him.

You misjudge my intentions. I am REALLY interested in biology and evolution. Just because there was a brief moment when Soviet Communists preferred Lamarck over Darwin, should not have any impact on our understanding of evolution.

I gave concrete examples which contradict Jurassic Park paradigm - that DNA is the unidirectional master of life process, modified only by mere chance and winnowed by external selection. I am sure that there will be more discoveries coming that will point toward more complex and intelligent design.

Of course, from the hindsight of two centuries you can find faults in Lamarck, but not smaller than in Darwin. The key ideas of Lamarck in a updated form will be vindicated in my opinion. Just my educated opinion.

39 posted on 11/13/2006 5:04:55 PM PST by A. Pole (Psalm 19: "The heavens declare the glory of God; and the firmament sheweth his handywork.")
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To: A. Pole
We know only a fragment of this amazing design.

I was wondering when you were going to show your I.D.

If it matters to you, I approve.

40 posted on 11/13/2006 5:10:18 PM PST by Oberon (What does it take to make government shrink?)
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