Posted on 08/27/2006 8:20:10 PM PDT by Ernest_at_the_Beach
Wow...
Man this would be some good news if this progresses....the money should flow for this research....
It seems like I read frequently that some new something-or-other has been discovered which cures/reverses cancer, and then I never hear of it again. This is the second time I've seen an article about this, so maybe there's something to it.
BTTT
Smoke em if you got em!
This is the sort of research all that 'anti-tobacco jihad' money should have been spent on all along.
Cure the disease.
Company's name was Cell Pathways...I think....
Googling :
*************************************AN EXCERPT **********************************
New drug target for inducing apoptosis in abnormal cells published in Cancer Research
HORSHAM, PA (July 5, 2000) -- Scientists at Cell Pathways, Inc. (Nasdaq: CLPA) and their collaborators have identified a new drug target that may play a key role in cancer cell survival. Exisulind (Aptosyn) and other compounds in the company's family of selective apoptotic antineoplastic drugs (SAANDs) inhibit this target, cyclic GMP phosphodiesterases of the PDE5 and PDE2 gene families that have been found to be over-expressed in cancerous and precancerous cells of the colon. The inhibition of these target proteins triggers a chain of events which results in the programmed cell death, or apoptosis, of cancerous and precancerous cells, but not normal ones. The drugs have additionally been shown to inhibit the growth of a broad variety of malignant tumor cells beyond colon tumors, in both cell culture and animal models of human cancers.
The new research appears in the July 1 issue of the journal Cancer Research. Cell Pathways scientists and their collaborators at the University of South Alabama College of Medicine, and the University of Colorado authored the paper.
Apoptosis is the body's response to a normal, orderly sequence of biochemical or physical signals by which damaged or "worn out" cells are eliminated to make way for healthy, new cells. When the mechanism of apoptosis goes awry, cells continue to multiply and grow inappropriately, forming a mass of tissue -- a cancerous tumor. In colon cancer, excessive cell growth occurs as the result of the accumulation of a regulatory protein, beta-catenin, caused by mutations in the adenomatous polyposis coli (APC) gene.
The researchers showed that exisulind and other SAANDs induce apoptosis in colon tumor cells by inhibiting the different forms of cGMP PDE in these cell lines. This results in a sustained increase in cGMP in the cells and the induction of cGMP-dependent protein kinase G (PKG). This rise in PKG activity causes beta-catenin to be degraded in neoplastic cells, thus triggering cell death by apoptosis through well-studied mechanisms. In addition, SAANDs that are better inhibitors of PDE5 and PDE2 than exisulind also show parallel increases in ability to induce
See post #8.
wow .... that's medical articles bookmarked today. Did you see the one on using your own adult stem cells to rejuvenate heart tissue?
That sounds just like the AIDS crowd.
How so?
Cancer was around before tobacco use, and will continue to be around if you could make all tobacco dissappear today, this instant.
Cure the disease, and everyone benefits, tobacco user or not.
This ain't bungholing, it's an F'n cigarette. SHeesh!
Or would you argue a few billion more dollars should be pissed down the endless computer model research rathole to tell us all cigarettes are bad for you?
I wonder if gay men are addicted to sex like smokers can't stop puffing. Needle-drug users are certainly gonzo from reality.
Anyway, it took generations before people knew about smoking hazards. AIDS was identified in a very short time by comparison. Practically nobody after the late 1980s can blame anyone but themselves if they've acquired it.
That is sad, tragic, and stupid.
Actually the same can be said of those who started smoking, probably since the '70s.
Great!! Hopefully this is a giant step forward in ending cancer.
God bless.
This sounds like one tremendously promising approach to killing cancerous cells!
Cure the disease, and everyone benefits, tobacco user or not.
Then there was no need to bring up tobacco.
The AIDS crowd didn't want to change their behavior, they wanted a cure instead.
Sadly your sarcasm is a reality in the world of the government..hence why this will probably not see the light of day.
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