Colonel Klink says: "Ve haff vays of makink you take your insulin."
Posted on 12/15/2005 9:24:52 PM PST by Marie
NEW YORK (AP) - Hoping to save hundreds of lives, health officials made a regulatory change Wednesday that will allow the city to track thousands of people with diabetes and occasionally prod them to take better care of themselves.
In doing so, New York will become the first American city to monitor diabetes in the same way health departments now commonly track people with HIV or tuberculosis.
It will also be treading new ground, and potentially raising some privacy concerns, by collecting information about people who have a chronic disease that isn't contagious or caused by an environmental toxin.
The city's health commissioner, Dr. Thomas R. Frieden, said the program's potential to save thousands of lives outweighs what it gives up in medical privacy.
Under a revised city code, most medical laboratories will be required to electronically forward the results of thousands of blood-sugar tests to the city's health department, which will then identify people having trouble controlling their diabetes.
Excuse me. I need to get my barf bag now.
Incoming (tyranny alert)
Asinine comparison. Diabetes is not contagious, so there is no public-health justification for tracking it.
I've been a Type I diabetic for 25 years, and my blood sugar control is nobody's business but mine. This is the price we will pay as the government gains an ever-greater stranglehold on the health system.
"Because you're so stupid that you need it."
Ooh, you forgot the monetary cost. Someone's going to have to be paid to do this.
Oh government, please hold my hand.
/sarcasm
Prod? By what means?
Does anyone think that this will stop with diabetes?
"Mr. Jones, our records indicate that you didn't have your federaly mandated 5 servings of fruits and vegetables yesterday. Please come with us."
Isn't that sweet??? *rubbery smile*
It's so cute! *coochy coo!*
But it's going to grow BIG REAL fast! *sigh!*
And a brand new bureaucracy is born...
Um ... have we all forgotten how to say, "None of your damn business"?
"Honey, why does this baby have this funny mark on its forehead? And why is its head spinning like that?"
"Ve must repart you to de government! De cholesterol ist too high!"
Stop that! It's not polite to stare at the horsemen.
No it doesn't.
This should read: The program's potential to meddle in millions of people's medical privacy has nothing to do with saving lives.
Using this kind of rationale the government can track anyone with even a minor aliment with the excuse that it's "for the greater good".
This is nothing short of liberals/socialists butting their collective noses into people's private lives.
Colonel Klink says: "Ve haff vays of makink you take your insulin."
And for those who continue to resist, how about loading them into boxcars and take them to camps where they can be reeducated or where a final solution to their problem can be reached. After all, early deaths reduce long-term health care costs.
Nope and it began with smoking. When they find they can tax it and make even more to help defray the health costs---errr I mean for the state's coffers...
Have your read your the HIPPA legislation? You know that one you had to sign about a year ago when you got prescriptions, at the Dr's office, dentist, and any other medical type person. You know---that one that improved privacy of medical records--RIGHT!!
What did MyGreatGrandfathers,Grandfathers,Father,Uncles,and I fight for? We all spilled blood and gave ours to spread liberty throughout the world only to lose it here to unelected socialist master planners
Tyrants on the Loose Again
Maybe they would do better if they actually tried to kill the infection that causes diabetes.
Title: Method of using IL-11 for treating gingivitis
United States Patent: 6,270,759
Inventors: Keith; James (Andover, MA); Schendel; Paul (Wayland, MA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Appl. No.: 337965
Filed: June 22, 1999
Abstract
Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria
Mastoparan-Induced Insulin Secretion from Insulin-Secreting ßTC3 and INS-1 Cells: Evidence for Its Regulation by Rho Subfamily of G Proteins
Rajesh H. Amin, Hai-Qing Chen, Rajakrishnan Veluthakal, Robert B. Silver, Jingsong Li, GuoDong Li and Anjaneyulu Kowluru
Departments of Pharmaceutical Sciences (R.H.A., H.-Q.C., R.V., A.K.) and Pharmacology (R.B.S.), Physiology, Radiology, and Biomedical Engineering, Wayne State University, and ß Cell Biochemistry Research Laboratory (R.H.A., H.-Q.C., A.K.), John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201; and John D. Dingell Veterans Affairs Medical Center and Argonne National Laboratory (R.B.S.), and Cardiovascular Research Institute (J.L., G.L.), National University Medical Institutes, National University of Singapore, Singapore 117597
Address all correspondence and requests for reprints to: Anjan Kowluru, Ph.D., Department of Pharmaceutical Sciences, College of Pharmacy and Health Professions, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48201. E-mail: akowluru@med.wayne.edu.
Mastoparan, a tetradecapeptide from wasp venom, stimulates insulin secretion from the islet ß-cells, presumably via activation of trimeric G proteins. Herein, we used Clostridial toxins, which selectively modify and inactivate the Rho subfamily of G proteins, to examine whether mastoparan-induced insulin secretion also involves activation of these signaling proteins. Mastoparan, but not mastoparan 17 (an inactive analog of mastoparan), significantly stimulated insulin secretion from ßTC3 and INS-1 cells. Preincubation of ßTC3 cells with either Clostridium difficille toxin B, which inactivates Rho, Cdc42, and Rac, or Clostridium sordellii toxin, which inactivates Ras, Rap, and Rac, markedly attenuated the mastoparan-induced insulin secretion, implicating Rac in this phenomenon. Mastoparan-stimulated insulin secretion was resistant to GGTI-2147, a specific inhibitor of geranylgeranylation of Rho G proteins (e.g. Rac), suggesting that mastoparan induces direct activation of Rac via GTP/GDP exchange. This was confirmed by a pull-down assay that quantifies the binding of activated (i.e. GTP-bound) Rac to p21-activated kinase. However, glucose-induced insulin secretion from these cells was abolished by toxin B or GGTI-2147, suggesting that the geranylgeranylation step is critical for glucose-stimulated secretion. Mastoparan significantly increased the translocation of cytosolic Rac and Cdc42 to the membrane fraction. Confocal light microscopy revealed a substantial degree of colocalization of Rac (and, to a lesser degree, Cdc42) with insulin in ß-cells exposed to mastoparan. Further, stable expression of a dominant negative (N17Rac) form of Rac into INS-1 cells resulted in a significant reduction in mastoparan-stimulated insulin secretion from these cells. Taken together, our findings implicate Rho G proteins, specifically Rac, in mastoparan-induced insulin release.
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