Oh, this can't be good.
Posted on 11/01/2004 9:49:26 PM PST by neverdem
CASES WITHOUT BORDERS
KWA'AL, Nigeria - The pond was about the size of a school swimming pool, except it was surrounded by dry mud pocked with hundreds of hoofprints.
A herd of goats was at one edge, drinking and defecating in the same spot. The sun was going down behind a thorn tree, backlighting 50 naked boys splashing one another in the warm dusk.
Where a colonialist romantic would have seen a landscape of native innocence, I saw a horror movie: there were worms in the brown water invisibly digging right through the boys' skin.
Kwa'al is a market village that exists only because the region's red dirt tracks meet a paved road here. Each morning, women walk in with sacks on their heads: potatoes, onions and cabbages that they pile by the road, hoping to earn $3 or so. It is rural and traditional; a nearby village is famous for the dogs it raises for meat.
Kwa'al is also a "schisto village." A third of its children have blood in their urine because of schistosomiasis, a parasitic disease transmitted by water snails. Also known as bilharzia, it is the second most common tropical disease in Africa, after malaria. Stuck to the mud wall of a building is a Health Ministry poster showing a silhouette of a squatting boy staring down, troubled, at the scarlet stream running out of him.
The blood is just a red flag for the real problem: children with heavy infestations of the worms, known as schistosomes, are stunted and do poorly in school.
An hour in Kwa'al is a mural of parasitology: a living schematic of how the life cycle of a human boy intersects the life cycle of a waterborne worm and the financial cycles of global public health.
When a team from the Carter Center and a pediatric parasitologist from the Centers for Disease Control and Prevention, Dr. Frank O. Richards Jr., drove into Kwa'al at 5 p.m., after a long day visiting villages at the ends of dirt roads, the local health volunteers began a demonstration of their prevention techniques.
As one man lectured some local chiefs, using a flip chart to explain the worm's life cycle, the children lined up at a small wood table. Their names were jotted in a notebook, and their heights measured on a stick with yellow, green, blue and red bars. Those who reached yellow, 35 inches tall, were handed one pill. The tallest children were handed four, which they swallowed with a cup of water dipped from a cooking pot.
In the West, doses are figured by the child's weight. But scales get broken, and marked sticks are easy to make. And all the children were so thin that height indicated weight accurately enough.
Unlike the nearby dog village, Kwa'al is Muslim - a prayer meeting with a loudspeaker at a mud mosque a few yards away nearly overpowered the lecturer - and Ramadan had begun. The children had to get dispensation from daytime fasting to take their pills. In some areas, health programs just shut down for Ramadan; at night, Nigeria's roads are too dangerous.
Almost all the children in line were boys. The volunteers survey schoolchildren, and Muslim girls here usually stay home, so surveys may miss them. But boys also have many more worms. In Africa, girls fetch water, but boys swim.
Meskwal Yusuf, a 15 year-old who looked 10, said he was "very happy'' to get his dose.
"I could see red in my urine, and my penis pained me," he explained. "I told my father. He told me people would come and bring drugs free, so I should not worry.''
The pills were praziquantel, which kill virtually all the worms. They cost 7 cents apiece. They are cheap because they're generic, made by companies in Germany, Cyprus and South Korea. (In 1983, when only one company made them, the pills cost $4.44 each at pharmacy prices.)
But the companies are not willing to donate the pills, so charities must buy them. The Carter Center can afford 200,000 a year - enough to treat six counties in central Nigeria.
According to a 1995 study by Dr. Michael Reich of the Harvard School of Public Health, it would take 423 million praziquantel pills a year to treat schistosomiasis worldwide. Together, the three drug companies make only 89 million.
"When you hear that, you realize the value of the donations from Glaxo and Merck and Pfizer," said Dr. Richards, the C.D.C. consultant.
(Pfizer, Merck and GlaxoSmithKline donate millions of their patented deworming and antibiotic drugs, which can cost several dollars each in American pharmacies, to programs fighting other parasites.)
Because of the chronic praziquantel shortage, the World Health Organization rations it: any village where fewer than 20 percent of the school-age children have blood in their urine gets no treatment. "Imagine that in Manhattan, if a kid showed up with blood in his urine," Dr. Richards said.
In any village where 20 to 50 percent of the children have bloody urine, only children get pills. And in any village where more than 50 percent have symptoms, the whole village gets pills.
In Kwa'al, 36 percent do. When the health volunteer took questions, several parents said they had blood in their urine, so why didn't they get pills too?
Those were the rules, the volunteer said.
"I'm a pediatrician," Dr. Richards said. "I'd love to blanket these areas. When you treat kids, their growth rates increase and their academic performance improves. But our position is W.H.O.'s position. We're not breaking ground here."
We jumped back in the truck to find the swimming hole, about 100 yards down the road.
Dr. Richards bent down to pick up a tiny snail. It was in a quarter-inch of water, but he used a leaf, not wanting to dip even the tip of his finger in.
"You can't keep a kid from urinating when he swims," he explained. "The eggs are in the urine. They infect the snails and develop into a form that invades human skin - a sharp head and a tail, sort of like a sperm. The head goes in, the tail snaps off, and it sets up shop in the human. Then, when it releases its eggs, they burrow their way through the body to reach the bladder."
He added, pointing to the youngsters splayed out in six inches of water, "That's why the boys have the heavy infections. They're lying there soaking up the schisto."
As if a lifeguard had shouted, the boys all came running out of the pond at once, toward me. I was standing near where they had dropped their shirts and shorts, but the piles were so dirty they might have been cow patties.
The last one out was limping on a stick, his back bent sideways. "Look," Dr. Richards shouted. "Polio." More than one plague had visited Kwa'al.
As they dressed, I recognized Meskwal and others I had seen at the pill table. They had run here faster than we had driven.
Did the water, I asked, make their skin itch? Yes, they answered. It meant that new parasites were digging in.
I asked them if they realized that this was how they got the blood in their urine.
"Yes, we know," Meskwal said. "Our parents tell us not to come. But as there is no water in the river, this is the only water we have to bathe with. This is the only way we can wash our clothes."
As long as boys like water, schistosomiasis will never be eradicated. The world is not ready to provide chlorinated pools, and even a widely heralded United Nations plan from the 1980's to provide clean wells in every country never came close to reaching its goals.
Instead, we settle for control: for a few thousand lucky boys, an annual deworming that does not cure, but substantially cuts their parasite load, giving them a chance to grow up - and outgrow the swimming hole.
yuck!
Wow, I just can't wait until the rotation at the UN puts this country in charge of the world's health problems.
Then you read about Africa, where they are behaving as if the last 100 years of bacteriology. genetic science, virology simply does not exist. WTF is wrong with these people?
Oh, this can't be good.
That can't be Kerry's xray. I distinctly see guts in that image.
It's not looking good, but what exactly are we looking at, if you please? Is this a case of schistosomiasis or trauma?
FReepmail me if you want on or off my health and science ping list.
F i g u r e i t o u t.(hint: it's not trauma)
Clinical History: Born in Egypt along the Nile Valley, child presents with frequency, urgency, dysuria and hematuria.
Findings:
1. Calcification of the distal two thirds of both ureters.
2. Bladder calcifications.
3. Seminal vesicle calcifications superimposed on bladder calcifications.
Diagnosis: Schistosomiasis GU tract.
Discussion: The causative organism is S. haematobium. The female parasite discharges eggs into the urine and feces. In fresh water, ova hatch into an intermediate form (miracidia) that infects the intermediate host, fresh water snails (genera Bulimus and Physopsis). The next form, cercaria, pass from the snail to water and penetrate human skin and pass into the lymphatics and migrate to the pelvic venous plexus. Ultimately eggs are deposited and eventually erode the bladder mucosa and the cycle begins again.
Infection results in a thickened and ulcerated mucosa initially and progresses to scarring and muscular hypertrophy. Pedunculated papillomas develop. Bladder capacity decreases. Involvement of distal 1/3 of ureters causes obstruction and subsequent hydronephrosis. 10% of cases develop calculi. Prostate and seminal vesicles may be affected. Calcifications of the bladder wall (4-56%), distal ureters (39%) and seminal vesicles late in the disease. Squamous cell carcinoma of the bladder is a late complication. Dahnert summarizes radiographic findings as follows:
Thanks for posting that. I sent the URL to my baby son in case he hasn't seen it. That's his line of work.
Diagnostic Imaging and Radiology
http://www.uhrad.com/
This certainly puts the prospect of an enlarged prostate at middle age in perspective.
F i g u r e i t o u t.
(hint: it's not trauma)
I don't pretend to have expertise as a radiologist. The possibility of acetabular fracture in each hip joint because of the discontinuities in the image struck me. I don't recall that many pelvic Xrays. It could be an artifact of developmental age or the angle at which the image was made. IIRC, radiology is an optional rotation in medical school. I always want to see the report from the radiologists.
While I was a resident, I had a patient present in extremis with Sheehan's Syndrome. Only after the lab results and history supported that diagnosis, after multiple CT and MRI studies were performed, did the radiology report mention an empty sella tursica, i.e. where you should have found a normal pituitary gland.
African AND Muslim ... that is about as backwards as you can get without being a liberal Democrat.
The pills cost 7 cents each, yet wages can be $3 a day; but they can't afford the pills? And dear old dad says "you'll have to wait until we get the drugs for free"?
I LOVE how the UN rations the health care, so that if only 19% of kids in a village have schisto, you get nothing. Typical bureaucrat thinking.
Well, so much for breakfast...
I wonder the same about people who swim in the water in Coney Island sometimes.
What are children supposed to bathe then if that's the only water?
The world is not ready to provide chlorinated pools, and even a widely heralded United Nations plan from the 1980's to provide clean wells in every country never came close to reaching its goals.
** That should be the government's responsibility not the world. The muslim run Nigerian government has its priorities in order, no women in swimming suits and swimming pools for boys lest they have any fun disease free.
BTW, there's nothing wrong with the people except the opportunities and choices that the government gives them. The governement has made radical muslim religion more of a priorities than providing medicine since they've also denied vaccines to children. I live in New York, and no African I know swims in a dirty pool of mud. In fact, after getting their own house a swimming pool is the next thing they get.
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