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Hearts of dying patients repaired with injection of their own cells [adult stem cells]
The Sunday Times ^
| April 25, 2004
| Jonathan Leake
Posted on 04/26/2004 8:27:22 AM PDT by syriacus
SCIENTISTS have been able to rebuild the hearts of people dying from cardiovascular disease by injecting them with cells that grow into healthy new tissue.
The success, the first of its kind, points to a future where many victims of heart disease western societys biggest killer could add years to their lives, researchers say. They hope that one day failing hearts will simply be rejuvenated by incorporating young new tissues into the ageing or diseased organ.
The research patients were injected with stem cells taken from their own bone marrow. The cells known for their power to grow into almost any type of human tissue quickly evolved into healthy heart cells that augmented and replaced their diseased predecessors.
Robert Kormos, professor of surgery at the University of Pittsburgh School of Medicine, said it was the first convincing evidence that stem cell transplants could replace surgery as a way of treating heart failure. He said: Such therapies could revolutionise our approach, which is largely palliative, to one that is truly regenerative.
He and other researchers warned, however, that so far the technique remained purely experimental and needed to be assessed on a far wider scale before being made generally available. The 20 patients in the study were all chosen because their hearts were failing so badly that they urgently needed cardiac bypass operations.
During the operations, 10 of the patients had bone marrow taken from their hips. Stem cells extracted from each patients marrow were then injected into their hearts wherever the doctors could find muscle damage. The other 10 patients were given the bypass operation but no stem cells.
Over the next six months the doctors compared the heart strength of the patients who received the stem cells plus the operation with the 10 who had only the bypass.
Dr Amit Patel, of Pittsburghs McGowan Institute for Regenerative Medicine, said the stem cells had prompted the emergence of strong, healthy new heart cells that grew into the old heart and rejuvenated it.
In several cases their hearts became almost as powerful as in a person with no heart disease. Patel said: Stem cell transplantation led to significant improvement in cardiac function in these patients, compared with the 10 control patients who had just the bypass operations.
Coronary heart disease is the leading single cause of death in Britain, killing about 125,000 people a year.
TOPICS: Miscellaneous; United Kingdom
KEYWORDS: ascr; health; healthcare; stemcell
In several cases their hearts became almost as powerful as in a person with no heart disease.Here's hoping this is a breakthrough.
1
posted on
04/26/2004 8:27:30 AM PDT
by
syriacus
To: commish
Bump for later read.
2
posted on
04/26/2004 8:30:03 AM PDT
by
commish
(Freedom Tastes Sweetest to Those Who Have Fought to Preserve It)
To: syriacus
As someone with serious heart problems, I find this fascinating. When I get some financial issues taken care of, I might talk to my cardiologist about this.
3
posted on
04/26/2004 8:32:43 AM PDT
by
Riley
To: Riley
As someone with serious heart problems, I find this fascinating.I hope something like this can help you.
4
posted on
04/26/2004 8:38:18 AM PDT
by
syriacus
(Cyberterror experts Clarke + Gorelick kept out ALL terrorists who were disguised as electrons.)
To: Riley
My sister has a bone marow disease and needed a bone marrow transplant. My family got tested and I was a perfect match. Instead of bone marrow they used my stem cells. It is an easy proceedure, one shot a day for 4 days and the donation takes 6 hours. I have been back every week since January to give plateletts for my sister. Right now plateletts and blood are in short supply.
When I was there, several of the patients where giving their own cells for later implanting.
I would encourage ALL FREEPERS to donate Blood and plateletts and register for the bone marrow donor list. There are ONLY 4.5 millon people on the list, in a nation of almost 300 million, that is shameful.
5
posted on
04/26/2004 8:51:00 AM PDT
by
bigj00
To: Riley
In the meantime, take 500mg. Hawthorn Berry (
Crategus Oxycantha)capsules morning, noon & night.
Been used for thousands of years to strengthen & rebuild heart muscle.
It's cheap & readily available ( I get mine at Target or Wal-mart), but not part of the medical mafia patents for profits warchest so Dr.'s pretend "it's something new & untested".
It's about as new as dirt!
6
posted on
04/26/2004 8:52:23 AM PDT
by
norraad
("What light!">Blues Brothers)
To: Riley
http://newsbureau.upmc.com/MediaKits/McGowan/McGowanBackground.htm Contact: Michele Baum
Patients and medical professionals may call 1-800-533-UPMC (8762) for more information.
Telephone: 412-647-3555
Fax: 412-624-3184
MCGOWAN INSTITUTE BACKGROUND INFORMATION
The McGowan Institute for Regenerative Medicine (MIRM) was launched in July 2001 to realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs. Established by the University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, the McGowan Institute serves as a focal point for the university's leading scientists and clinical faculty who are working to develop tissue engineering, cellular therapies, treatments for wound healing, synthetic blood additives, biosurgery and artificial and biohybrid organ devices.
7
posted on
04/26/2004 9:03:20 AM PDT
by
syriacus
(Cyberterror experts Clarke + Gorelick kept out ALL terrorists who were disguised as electrons.)
To: syriacus
McGowan Institute for Regenerative MedicineThe Institute takes its name from the McGowan Center for Artificial Organ Development, which has been incorporated into the McGowan Institute. Through the McGowan Institute's expanded role and mission, other university faculty have joined forces to address promising opportunities in tissue engineering, adult-derived stem cell research and wound healing.
8
posted on
04/26/2004 9:09:56 AM PDT
by
syriacus
(Cyberterror experts Clarke + Gorelick kept out ALL terrorists who were disguised as electrons.)
To: norraad
It's cheap & readily available ( I get mine at Target or Wal-mart), but not part of the medical mafia patents for profits warchest so Dr.'s pretend "it's something new & untested". It MIGHT be safe for long-term use, but current studies have not extended past 16 weeks.
http://www.naturaldatabase.com/monograph.asp?mono_id=527&brand_id=
9
posted on
04/26/2004 9:26:40 AM PDT
by
Born Conservative
(It really sucks when your 15 minutes of fame comes AFTER you're gone...)
To: Born Conservative
The best-known herb for the heart in western herbalism is Hawthorn, which is a small tree or shrub that grows throughout the northern hemisphere. The fruits, flowers, and leaves are processed into tinctures and other kinds of extracts available in capsules or tablets in the U.S. and other parts of the world.
The comely hawthorn is a dense tree with small, sharp thorns growing to 25 feet. It has small white flowers with rose-like petals and bright red berries containing one or two large seeds. Hawthorns are native to Europe, North America and Asia.
Dioscorides, the most reliable of the ancient authors on plant medicines, called Crataegus "Oxuakantha", which was retained by Linnaeus in the name C. oxyacantha, an old name for C. laevigata. Although many botanical and herbal writers from the15th through the 17th centuries took this plant to be a kind of Crataegus, Parkinson (1640) determined that it was likely a Pyracantha--common ornamental shrubs with small red berries. It is listed as C. pyracantha in Gunther's edition of Dioscorides (1933), today referred to the genus Pyracantha, a genus not particularly lauded for its healing properties. Galen's "Oxyacanthus" is also certainly a Pyracantha, Pyrus (pear) or Mespilus (medlar). The latter three genera are closely allied and until the 17th century were likely to be poorly distinguished from Crataegus (Parkinson).
Gerard (1633), one of the best-known of the Rennaissance herbalists, called hawthorn oxyacanthus, white thorne, or hawthorn tree. The latter two, and the name "May-Bush," are still common in England. In Germany hawthorn is now called weifdorn, while in France it is referred to as l'epine noble (the noble thorn) because it was supposedly used for Christ's crown of thorns.
In both the East and West, hawthorn has been used for millenia as both a food and a medicine. The current use of hawthorn for heart conditions dates back to the 17th century, according to the French doctor, Leclerc. Green, an Irish doctor, is known to have used it extensively--though secretly--for heart ailments. After his death in 1894, his daughter revealed the famous cure to be a tincture of the ripe berries of Crataegus oxycanthus. In Europe, both homeopathic and allopathic doctors used the herb for various heart and cardiovascular ailments from the late 19th through the early 20th centuries--and with great clinical success. Hawthorn had entered American clinical practice by 1896--only to fade from use in the 1930s.
Over the centuries legends about hawthorn have abounded in England and Europe. The poets, too, have sung its praises, as in Chaucer's phrase:
Marke the faire blooming of the Hawthorne tree
Who finely cloathed in a robe of white,
Fills full the wanton eye with May's delight.
Goldsmith, in his "Deserted Village," penned these well-known lines:
The Hawthorn-bush with seats beneath the shade,
For talking age and whispering lovers made.
Assmann, a German homeopathic doctor from the late 1800s, said the following regarding hawthorn's use as a cardiac medicine:
Crataegus is no panacea, but for the handling of chronic illness, it is much more suitable than digitalis [foxglove] and strophanthus, because it has no unpleasant side-effects and no cumulative effects. Its success can be achieved if the tincture of the fresh ripe fruit in a suitable dose (3X daily 10-20 drops after meals) is prescribed.
Today, hawthorn is an official drug in the Pharmacopoeias of Brazil, China, Czechoslovakia, France, Germany, Hungary, Russia, and Switzerland. As a measure of its lasting popularity, it is an ingredient of 213 commercial European herbal formulas, which are mostly for the treatment of heart and cardiovascular ailments.
I have a special affection for this herb, because it helped my father strengthen his heart and significantly increase the quality of his circulation. Twenty-six years ago he had a heart attack and has since been taking hawthorn in extract form for over 15 years with excellent results.
The extract of hawthorn can increase blood flow to the heart muscle itself, helping to counteract one of the most common modern causes of death in industrial countries--heart attack due to lack of blood flow to the heart. In pharmacological tests on both animals and humans, hawthorn has been shown to improve the contractility of the heart muscle (which can lead to a stronger pumping action of the heart), increase cardiac performance and output, lower the peripheral vascular resistance (reducing the workload of the heart), steady the heartbeat (antiarrhythmic effect), as well as increasing the heart's tolerance to oxygen deficiency, such as might happen during stress or excitement, or in diseases where the arteries are partially blocked.
In Europe, thousands of doctors prescribe hawthorn to prevent cardiovascular disease or to help alleviate symptoms of mild to moderate problems. It is considered so safe that it is sometimes prescribed concurrently with heart medications such as digitalis. Hawthorn is also considered a mildly calming herb for the nervous system--an appropriate bonus considering that stress and nervousness often accompany cardiovascular problems.
In my own experience, it is the first herb, besides garlic, that should be added to one's daily dietary regimen when there is any suspicion of problems of cardiovascular disease. If one has a family member who has heart or vascular problems, or for people eating a diet that includes moderate to high levels of fat (especially from dairy products or red meat), or who are stressed or using stimulants (such as coffee), hawthorn is an excellent protector.
Initially, hawthorn berries were the only part of the plant used in making extracts but eventually the flowers and leaves were added, as they were shown to have significant concentrations of the active flavonoids as well. The extract can be taken long-term, is very safe, and will not interfere with any medications, according to the official European Community monograph (ESCOP) on hawthorn. The daily dose is 2-4 dropperfuls of the tincture, or 1-2 tablets of the standardized extract, morning and evening.
Hawthorn for the Heart
© Christopher Hobbs L.Ac., A.H.G.
10
posted on
04/26/2004 10:45:32 AM PDT
by
norraad
("What light!">Blues Brothers)
To: norraad
Thanks for all of the information; it sounds as though there is a legitimate use for Hawthorn. The reason I posted my post is that many people embark on using herbs without fully investigating them beforehand; this can be quite dangerous.
For instance, let's say for the sake of argument that aspirin, which is derived from Birch Bark, has not been invented/synthesized yet. It's sold to people as an herb that helps with pain, and many people use it. Being that it is an herb, it's not regulated by the FDA. Many people think that if a little bit helps, then a lot would be even better. Ultimately, dozens of people who overuse the "herb" develop kidney failure (aspirin is known to cause kidney damage in those with kidney disease and/or in those who use higher than recommended doses). The caveat is that just because an herb may help one disease, it's possible that it can have an adverse effect elsewhere in the body.
11
posted on
04/26/2004 11:26:42 AM PDT
by
Born Conservative
(It really sucks when your 15 minutes of fame comes AFTER you're gone...)
To: syriacus
I don't know if I'd be a good candidate, on second thought. My problem is plaque deposits and blood clots. The heart muscle itself is relatively intact- some damage, but it is filling up with 'stuff'. So are a whole bunch of arteries. Already had a bypass and two Angioplasties.
That's the real problem, and this doesn't seem to address that.
12
posted on
04/26/2004 11:29:13 AM PDT
by
Riley
To: Born Conservative
It's so easy to fully investigate today, there's really no excuse to be dependent on Dr.'s trained only in a narrowminded educulture for profit only system.
I do my own research on google.
Here's some more I found since last post.
Ginkgo biloba is the oldest living tree species in the world. Ginkgo trees can live as long as a thousand years. Using ginkgo for asthma and bronchitis was described in the first pharmacopoeia, Chen Noung Pen T'sao, dating to 2600 BC (6208). Ginkgo is the most frequently prescribed herbal medicine in Germany (6208) and is the preferred treatment for dementia.
Hawthorn tree will attain a height of 30 feet (9 meters) and lives to a great age sometimes to over 400 years. It possesses a single seed-vessel to each blossom producing a separate fruit, which when ripe is a brilliant red, this in miniature is a stony apple. In some districts these mealy red fruits are called Pixie Pears, Cuckoo's Beads and Chucky Cheese. Carrion insects mostly fertilize the flowers and the suggestion of decomposition in its perfume, attracts those insects that lay their eggs and hatch out their larvae in decaying animal matter. The wood of the hawthorn was used for making small articles for its wood has a fine grain and takes a beautiful polish. The root-wood was used for making boxes and combs. It also makes excellent fuel, making the hottest wood-fire known, and it used to be considered more desirable than Oak for oven-heating. Charcoal made from it has been said to melt pig-iron without the aid of a blast. The stock of the hawthorn is employed not only for grafting varieties of its own species, but also for several of the garden fruits closely allied to it, such as the medlar and pear. The Hawthorn is called Crataegus Oxyacantha from the Greek kratos, meaning hardness (of the wood), oxcus (sharp), and akantha (a thorn). The German name of Hagedorn, meaning Hedgethorn, shows that from a very early period the Germans divided their land into plots by hedges; the word haw is also an old word for hedge. The name Whitethorn arises from the whiteness of its bark and Quickset from its growing as a quick or living hedge, in contrast to a paling of dead wood. The leaves have been used as an adulterant for tea. An excellent liquer is made from Hawthorn berries with brandy. Chinese herbal medicine regards it as cool, astringent taste It helps to increase the cardiac output of blood volume and increase the efficiency of the heart. This helps improve the oxygen flow to the heart muscle itself (hypoxaemia) and helps alleviate the pain associated with angina. Second, the heart muscle is strengthened. Haw has long been associated with hedges as in Germany and the British Isles it has long been used to separate fields and acts as a natural form of barbed wire The heart is our life-pump and when it is not properly fed with wholesome foods it suffers malfunction (weakness and heart attack) causing the heart failure condition that is one of the worlds greatest killers. The mucous less diet used over a period of time can rebuild a heart to a good strong condition, but if the heart, its valves and other working parts are in a weakened condition and need quick help, we use a heart food or tonic. This food is Hawthorn, the cardiac tonic. This herb has curative properties to treat organic and functional heart disorders such as dyspnoea, rapid and feeble heart action, hypertrophy (valvular insufficiency and heart oppression). It has recently been discovered that the leaves are more powerful than the berries for use as a cardiac tonic Crategus Oxycantha contains amygdalin, crategolic acid, the alkaloid crataegin, a mixture of saponins, triterpene acid (i.e. oleanolic acid and ursolic), purine and flavonoid glycosides
13
posted on
04/26/2004 11:45:47 AM PDT
by
norraad
("What light!">Blues Brothers)
To: norraad
CoQ10 has also been shown to have very good results for cardiovascular function. Some also claim it has significant anti-cancer functions.
As far as this being the first time stem cells have been used, I'm not sure of that. In Europe, they have been using stem cells extracted from the human nasal passage for repairs of spinal cord injuries. Early results are in, and it has quite a bit of good effect, the stem cells actually wrap themselves around the damaged nerves, and rebuild them, and their function. It was profiled on Nova a while back.
14
posted on
04/26/2004 11:54:49 AM PDT
by
djf
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