Posted on 10/24/2003 9:04:06 AM PDT by blam
You're hardwired to go mad
October 23 2003 at 10:30AM
Washington - American and Japanese researchers said on Thursday that they had found a genetic mutation that causes obsessive-compulsive disorder and other mental illnesses and said some patients had a second mutation that made their conditions worse.
The rare finding could make it easier to discover better treatments for the disorder, one of the top 10 leading causes of disability worldwide.
Dr Norio Ozaki of Fujita Health University School of Medicine in Japan and colleagues at several American institutions - including the University of Pittsburgh and Yale University - worked on the study, which was published in the journal Molecular Psychiatry.
The gene is called the human serotonin transporter gene, hSERT, and helps control how the body uses serotonin, a message-carrying chemical or neurotransmitter linked with mood.
Some anxiety drugs and antidepressants target serotonin, but the researchers said patients with the mutations are not helped by these drugs.
"In all of molecular medicine, there are few known instances where two variants within one gene have been found to alter the expression and regulation of the gene in a way that appears associated with symptoms of a disorder," said Dr Dennis Murphy of the National Institute of Mental Health, who worked on the study.
The researchers analysed DNA from 170 people, including 30 patients with obsessive-compulsive disorder (OCD), 30 with eating disorders such as anorexia and 30 with seasonal affective disorder - which can cause depression and other symptoms in dark winter months.
They also looked at the DNA of 80 healthy people.
A specific mutation in the hSERT gene was seen in two patients with OCD and their families, but not in other patients.
With such a rare mutation showing up, the researchers believe it is likely to be found in other families with OCD and related disorders.
They interviewed relatives of the patients and found six of the seven people with the mutation had an obsessive-compulsive disorder, and some also had anorexia, Asperger's syndrome, which is a form of autism, social phobia or were abusers of alcohol.
A second mutation was found in hSERT in two patients, giving them a "double dose." The patients and their siblings had especially difficult to treat versions of OCD, the researchers said.
I'd believe that, my momma always told me I was born nuts...
The use of drugs to moderate the effects of chemical imbalances just makes the problem worse.And I'm supposed to believe the pharmacuetical companies don't know this.
LSD is a serotonin analog, which may account for the similarity of some manifestations of mental illness - sensory misinterpretations and delusions, a preference for Jimi Hendrix albums - to an acid trip.
Wait a minute...you're not implying that this was posted by...by THEM, are you?
The pieces are starting to fall into place...
With all due respect to your studies, I believe there is indeed a place for correcting chemical imbalance in some patients. I am very close to one who has received tremendous benefit over the years thanks to a seritonin reuptake inhibitor.
Yes the giant ants
Them are everywhere!!!!
Be wary, yes.
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