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New Research Suggests Cause of Rare Blood-Clotting Side Effect From COVID-19 Vaccine
Epoch Times ^ | 02/16/26 | Marina Zhang

Posted on 02/16/2026 8:26:24 PM PST by SeekAndFind

In early 2021, some patients were developing a rare yet life-threatening condition in which their blood would clot after getting a COVID-19 vaccine.

In these patients, their bodies were mistakenly attacking their own platelets, causing them to clump together and resulting in blood clots and low platelet counts. Researchers didn’t know why.

Now, a new study may offer an answer.

In a study published in The New England Journal of Medicine, researchers in Australia, Germany, and Canada analyzed 100 patients who took adenovirus vaccines and developed vaccine-induced immune thrombotic thrombocytopenia, also known as VITT.

They found that VITT was likely driven by a change in the antibodies, causing them to switch from harmless to harmful.

“This was the missing link that explains how a normal immune response can, in very rare cases, become harmful,” Jing Jing Wang from Flinders University said in a press release.

Harmful Antibodies

When the immune system encounters foreign invaders like viruses, bacteria, and vaccines, which mimic an infection, one way the body fights them off is to mass-produce antibodies.

These antibodies bind to the foreign invader, putting a target on its back so that other immune cells can kill it.

When patients were given the adenovirus vaccine, their bodies produced many antibodies that targeted components of the vaccine.

When antibodies are mass-produced, new changes are introduced to create the optimum antibody that can kill off invaders. In the case of VITT, some antibodies developed a single change that produced a harmful antibody instead.

Since some parts of platelets and adenoviruses share similarities, this single error made the new antibodies more likely to bind to platelets rather than adenoviruses.

“Exactly how or why this specific mutation occurs, I am not sure. It might all just be a random event,” Dr. Theodore Warkentin, a co-author of the study and professor emeritus of pathology and molecular medicine at McMaster University, told The Epoch Times.

These antibodies bind to platelets, forming a mini traffic jam inside blood vessels—essentially a blood clot.

Other Predisposing Factors

The single error is only one part of the story.

Digging back further into patients’ medical histories, researchers found that these patients also had two other contributors: a prior adenovirus infection and a certain genotype.

Most of the patients were able to mount a very fast response to the vaccine, which suggests they were likely infected with adenoviruses before.

Of the 100 VITT patients analyzed, all inherited a common gene that is present in 60 percent of people of European descent, which may explain why VITT was a greater concern in Western countries. In simple terms, many people in these populations carry the gene, and some had prior adenovirus infections that produced adenovirus antibodies.

When they got an adenovirus vaccine, their bodies mounted a stronger reaction than they would if they had not been exposed to adenovirus previously, and a select few then developed harmful changes to their antibodies, leading to VITT.

“We think VITT will only occur in patients who have the genotype,” Warkentin said. However, he added that there can always be exceptions.

His research has found that adenovirus infections can also cause similar blood clotting, and he suspects that other viruses may cause the same condition.

Unpredictable Reactions to Vaccines

The researchers say the finding could allow vaccine manufacturers to create safer formulations that do not cause this dangerous reaction.

Previous research by the same authors established that VITT was likely caused by the adenovirus aspect of the vaccine, not other components.

Other studies have linked COVID-19 infection and mRNA vaccines to rare blood-clotting events, potentially related to spike proteins.

Though this study identified the mechanism for VITT, why the body triggers this reaction is still unknown. Warkentin added that he believes whether a person develops adverse reactions depends largely on chance.

Every person is different, and research shows that a small percentage respond differently than expected because immune responses vary.


TOPICS: Health/Medicine; Science; Society
KEYWORDS: clotshot; covid19; sideeffects; vaccines

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1 posted on 02/16/2026 8:26:24 PM PST by SeekAndFind
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To: SeekAndFind

Not the mRna stuff.

These were side effects from real possible VAX.

But journalism, who cares


2 posted on 02/16/2026 8:35:43 PM PST by algore ( )
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To: algore

“These were side effects from real possible VAX.”

Not available to the general public.


3 posted on 02/16/2026 8:38:40 PM PST by TexasGator (1.1~I11:/)
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To: SeekAndFind

BK MK


4 posted on 02/16/2026 8:42:00 PM PST by Cold Heart
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To: Cold Heart

“BK MK”

File under fake propaganda.


5 posted on 02/16/2026 8:51:52 PM PST by TexasGator (1.1~I11:/)
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To: TexasGator

What part is fake? I have had the condition since my clot shot, five years now.


6 posted on 02/16/2026 9:01:42 PM PST by Cold Heart
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To: Cold Heart

He’s an idiot troll, pay no attention to him.


7 posted on 02/16/2026 9:40:17 PM PST by Bikkuri ('China and India were ever going to be serious allies hasn’t been paying attention)
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To: Jane Long; ransomnote; SecAmndmt; Jan_Sobieski; Roman_War_Criminal; aMorePerfectUnion; ...

Rare?

They’re still trying to convince people the vax is safe.


8 posted on 02/16/2026 10:39:04 PM PST by metmom (He who testifies to these things says, “Surely I am coming soon." Amen. Come, Lord Jesus….)
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To: metmom

Two of my relatives and my supervisor died at around the same time after the shot. I don’t consider that rare.


9 posted on 02/16/2026 11:00:06 PM PST by roving
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To: TexasGator

I would have loved to see you tell that to my relative who died from brain cancer soon after getting the shot. He even blamed the shot.


10 posted on 02/16/2026 11:01:53 PM PST by roving
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To: SeekAndFind

There were VERY good reasons we FReepers called it the ‘clot shot’.

I lost a couple of cousins who died suspiciously shortly after getting their shots. But fortunately, they didn’t ever get COVID again.

PS Why were some gov’t agencies bribing people to get shots via lottery prizes


11 posted on 02/16/2026 11:52:44 PM PST by Oscar in Batangas (An Honors Graduate from the Don Rickles School of Personal Verbal Intercourse)
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To: metmom

They’re making vaccines that kill dogs now.

The “new” rabies vax is the worst.

Usual suspects.


12 posted on 02/17/2026 12:04:59 AM PST by Salamander ( Please visit my profile page to help me go home again. https://www.givesendgo.com/GCRRDa)
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To: SeekAndFind

I’ve researched various blood clotting factors as a result of caring for a family friend who moved into our home as a result of a severe stroke.

When we are in our mother’s womb, our lungs do not function. There is no respiration. Rather than blood being pumped from the right atrium to the right ventricle and on through the pulmonary artery to the lungs, and finally back to the left atrium, there is a hole through the septum between the right and left atrium.

This hole, called a patent foramen ovale or (PFO), allows the blood to bypass the lungs and go directly to the left atrium, and then to the left ventricle where it is pumped through the brain and the rest of the body.

This hole or PFO normally closes after birth, forcing the blood to flow through the lungs where it releases CO2 and becomes oxygenated.

However, in about 30% of the population this hole never closes. If it is open, blood clots that would normally get screened in the lungs and become a pulmonary embolism get pumped directly through the hole and end up in the brain causing strokes. Life expectancy depends upon the size of the PFO. Most people who have them are unaware of it. It can be surgically corrected.

There are over a dozen blood clotting factors. The one referenced in this article is Factor 4.

Platelet factor 4 (PF4), or CXCL4, is a small cytokine protein released by activated platelets during blood clotting, crucial for promoting coagulation and immune responses. It binds heparin, plays a role in heparin-induced thrombocytopenia (HIT), and has been identified as a potential factor in brain rejuvenation.

Key details regarding PF4:

Function: Released from platelet
-granules, it accelerates blood clotting and aids in inflammation.

Clinical Significance: PF4 binds to heparin, and antibodies against this complex can cause Heparin-Induced Thrombocytopenia (HIT). It is also implicated in vaccine-induced immune thrombotic thrombocytopenia (VITT).

Other Roles: It has anti-angiogenic properties (inhibits new blood vessel growth).

Research: Recent studies indicate PF4 may have rejuvenating effects on the brain.

In the specific case I spent weeks researching to help my friend, she had Factor V Leiden. Factor V Leiden is a common inherited genetic mutation that causes hypercoagulability, meaning the blood clots too easily.

She also had Von Willebrand factor (VWF), a critical blood glycoprotein that acts as “glue” to enable platelets to adhere to injured blood vessel walls, initiating blood clotting.

Thus the stroke was unique in that there were both clots and hemmorages. This made it very difficult to treat.
Her clotting factors were destabilized by high estrogen levels caused by a lower abdominal tumor.


13 posted on 02/17/2026 12:13:44 AM PST by tired&retired (Blessings )
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To: SeekAndFind

My own research indicated that the spiked proteins from Covid-19 caused the AV node of the heart to fire prematurely causing a decreased action potential to flow through the Bundle of His and Purkinje fibers to the left ventricle, resulting in decreased muscle contraction and blood pumping ability.

The AV node is the heart’s pacemaker. It acts like a capacitor on an electric motor, accumulating the electrical charge to a higher level and then releasing a stronger charge to turn the motor. If the capacitor loses this ability, the motor often won’t have the ability to start turning.

The only cure I found was to cleanse your body of the spiked proteins.


14 posted on 02/17/2026 12:27:22 AM PST by tired&retired (Blessings )
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To: tired&retired

“Platelet factor 4 (PF4), or CXCL4, is a small cytokine protein released by activated platelets during blood clotting, crucial for promoting coagulation and immune responses.”

That sounded familiar. A search brought up the following. Of course it is sold as a positive (enhancing the immune response), but I imagine it also increases the risk of a blot clot in “rare” cases.

AI Overview

mRNA COVID-19 vaccines (e.g., Pfizer-BioNTech, Moderna) induce an immune response by prompting cells to produce spike proteins
. This process, along with the lipid nanoparticles, increases cytokines (e.g., CXCL10, IFN-gamma) signaling immune activity. Cytokine levels, indicating humoral immune response, may remain altered for up to a year.
Key Details on mRNA Vaccines and Cytokines:

Cytokine Profile Changes: Vaccination results in an increased level of circulating cytokines, representing a persistent immune response.
Vaccine Mechanism: The mRNA-lipid nanoparticle structure is highly inflammatory, stimulating this cytokine production.
Specific Cytokines: Key cytokines involved include CXCL10 and IFN-gamma, which are involved in immune cell signaling.
Duration: Studies indicate that these altered cytokine profiles can persist for at least one year in some individuals, particularly younger adults.
Adjuvant Potential: Research is ongoing into using specific cytokines, such as interleukin-12 (IL-12), as adjuvants to further enhance the effectiveness of mRNA vaccine


15 posted on 02/17/2026 12:29:27 AM PST by 21twelve (Ever Vigilant - Never Fearful)
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To: tired&retired

If Factor PF4 blocks heparin, it blocks blood thinning. This directly allows increased clotting.

Heparin is often given during surgery to stop blood clots from forming or used after stroke to dissolve clots.

Heparin is primarily used after specific types of ischemic stroke—particularly cardioembolic—to prevent further clots, but its use is controversial due to high bleeding risk. It is generally not used for acute ischemic stroke without clear indication (like atrial fibrillation) or hemorrhagic stroke, as it can cause fatal brain hemorrhage.


16 posted on 02/17/2026 12:37:06 AM PST by tired&retired (Blessings )
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To: 21twelve

I got the non mRNA Covid-19 vaccine as I travel internationally and needed it to travel.

It almost killed me. Spinal paralysis for a week.

It cleared after a week, so I drank a glass of whole milk before bed as I frequently do. My entire body instantly was covered in hives. Took a Benadryl and it cleared up.

Not realizing the milk caused the hives, the next evening I had another glass of milk with the same result.

When milk is homogenized, it is sprayed through a high pressure nozzle at over 3,000 PSI. This breaks the milk lipid particles up so small that they are rapidly transferred from intestine to bloodstream, acting as lipid transport vehicles for the spiked proteins.

I was back on the dairy farm the following week and drank raw milk that was not homogenized with no reaction. Over time, as I eliminated the spiked proteins in my body, I can drink store milk again.

In raw milk the lipid particles are to big to pass into the bloodstream.


17 posted on 02/17/2026 12:50:28 AM PST by tired&retired (Blessings )
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To: SeekAndFind

Covid flu SHOT, not vaccine. They LITERALLY changed
the definition of the word vaccine, so you know it ain’t one. Just like they LITERALLY changed the definition of the word pandemic a few months before they unleashed the world’s greatest psych op.


18 posted on 02/17/2026 1:36:18 AM PST by GrumpyOldGuy
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To: SeekAndFind; All

BTW...Where IS Fauci hiding out?


19 posted on 02/17/2026 2:21:30 AM PST by SMARTY (In politics, stupidity is not a handicap. Napoleon Bonaparte I)
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