New therapy combination yields high remission rates in early-stage Hodgkin lymphoma (97% @ 28 months)

Medical Xpress / University of Texas MD Anderson Cancer Center / Blood Journal ^ | Jan. 25, 2025 | Jade Waddy / Jeremy S. Abramson et al

[ConservativeMind]

Patients with early-stage Hodgkin lymphoma had impressive response rates when treated with a novel combination of therapies—brentuximab vedotin and nivolumab combined with chemotherapy drugs doxorubicin and dacarbazine—according to a study.

"By pairing modern targeted therapies with a shorter course of chemotherapy, we're seeing strong outcomes that improve historical standards and reduce treatment intensity," said senior author Hun Ju Lee, M.D., associate professor of lymphoma.

A total of 154 patients were treated with the novel combination on this trial. Some 96% of patients had some level of response to treatment, and 92% had a complete response with no signs of cancer seen on scans after treatment.

These high response rates were observed in both lower-risk and higher-risk early-stage patients. Among those who achieved a complete response, 96% stayed in complete remission for at least two years. At 28 months of follow-up, 97% of patients were alive without their cancer returning.

Side effects were common for patients but manageable. Of note, no patients experienced febrile neutropenia.

What the results mean for future treatment of these patients Traditionally, patients with early-stage Hodgkin lymphoma are treated with the standard chemotherapy combination, and some also receive radiation. In this study, researchers determined that the new combination may allow patients to receive less chemotherapy.

"This treatment is highly effective and a promising option for people with early-stage, non-bulky Hodgkin lymphoma," Lee said.

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TOPICS: Health/Medicine
KEYWORDS: hodgkinlymphoma; therapy

[ConservativeMind]

“…brentuximab vedotin and nivolumab combined with chemotherapy drugs doxorubicin and dacarbazine…” It is a short course of chemo.

97% had no cancer at 28 months.

[ConservativeMind]

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[Secret Agent Man]

I’m guessing they are using AI to figure out these potential combos and then test some of them out.