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Posted on 01/24/2026 6:29:25 PM PST by ConservativeMind
Overuse of antibiotics has accelerated the development of bacterial resistance to conventional drugs, a global health crisis projected to result in more than 10 million deaths annually by 2050. The multidrug-resistant bacterium Pseudomonas aeruginosa accounts for approximately one-fifth of hospital-acquired pneumonia cases and is associated with severe illness and increased mortality.
Nitric oxide is a therapeutic gas that researchers helped establish as a life-saving therapy for hundreds of thousands of newborns with congenital heart disease.
Nearly 30 years later, investigators report that high-dose inhaled nitric oxide (iNO) demonstrates potential antimicrobial activity in preclinical models and is safe and feasible in early human studies, supporting further clinical investigation.
"This study provides a translational foundation rather than a definitive clinical solution," said first author Binglan Yu, Ph.D. "Our findings demonstrate strong preclinical antipseudomonal effects together with reassuring human safety data."
"These results justify the careful design of Phase II and Phase III clinical trials to formally assess clinical efficacy," added Bijan Safaee Fakhr, MD.
In the study, researchers first demonstrated dose-dependent killing of Pseudomonas aeruginosa using nitric oxide-releasing compounds in vitro. They then showed that pigs with experimental P. aeruginosa pneumonia treated with high-dose iNO (300 parts per million) exhibited reduced bacterial burden, along with improved oxygenation and other markers of lung infection, compared with untreated animals.
To assess feasibility and safety in humans, the investigators evaluated repeated high-dose iNO exposure in 10 healthy volunteers and two critically ill patients affected by multidrug-resistant bacterial infection.
The treatment was well tolerated, with no serious safety concerns observed. A retrospective analysis of patients who received high-dose iNO in clinical settings, mostly during the COVID-19 pandemic, further supported the safety profile of this approach.
(Excerpt) Read more at medicalxpress.com ...
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“The treatment was well tolerated, with no serious safety concerns observed. A retrospective analysis of patients who received high-dose iNO in clinical settings, mostly during the COVID-19 pandemic, further supported the safety profile of this approach.”
This seems a no-brainer to help in extreme situations.
Is this laughing gas?
That was their move up from inhaling NOS from whipped cream cans, hence the name whippets.
No. Laughing Gas is Nitrous Oxide.
Nitrous oxide, I believe
Nitrous Oxide == N2O (dental anaesthetic)
The only problem is we had a great difficulty trying to interview patients who were taking the therapy, because they wouldn’t stop giggling
Oh, right. Nitrous oxide versus nitric oxide.
Bkmk
*yawn*
If you’re interested in a solution you can have now in your medicine cabinet
https://freerepublic.com/focus/f-bloggers/3831003/posts
They give you Nitrous if Nitric doesn’t work out.
I’ll look at it.
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