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Posted on 01/01/2026 5:23:24 PM PST by ConservativeMind
For over a century, Alzheimer's disease (AD) has been considered irreversible.
Now, research has challenged this long-held dogma in the field.
Through studying diverse preclinical mouse models and human AD brains, the team showed that the brain's failure to maintain normal levels of a central cellular energy molecule, NAD+, is a major driver of AD, and that maintaining proper NAD+ balance can prevent and even reverse the disease.
NAD+ levels decline naturally across the body, including the brain, as people age. Without proper NAD+ balance, cells eventually become unable to execute critical processes required for proper functioning and survival.
The team showed that the decline in NAD+ is even more severe in the brains of people with AD, and in mouse models.
The research team tested whether preventing the loss of brain NAD+ balance before disease onset, or restoring brain NAD+ balance after significant disease progression, could prevent or reverse AD, respectively.
The study was based on their previous work, showing that restoring the brain's NAD+ balance achieved pathological and functional recovery after severe, long-lasting traumatic brain injury. They restored NAD+ balance by administering a pharmacological agent (P7C3-A20).
Remarkably, not only did preserving NAD+ balance protect mice from developing AD, but delayed treatment in mice with advanced disease also enabled the brain to fix the major pathological events caused by the genetic mutations. Moreover, both lines of mice fully recovered cognitive function.
"Restoring the brain's energy balance achieved pathological and functional recovery in both lines of mice with advanced Alzheimer's. Seeing this effect in two very different animal models, strengthens the idea that restoring the brain's NAD+ balance might help patients recover from Alzheimer's."
Dr. Pieper emphasized that currently available over-the-counter NAD+ precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer.
(Excerpt) Read more at medicalxpress.com ...
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Several precursors to NAD+ exist. One I take is a powder form of nicotinamide riboside that lets me use a small 1/8 teaspoon to get under 50 mg of nicotinamide riboside. That is a fraction of normal doses in capsules.
Bkmk
Computer models are not reality.
Nice if the computer model results in something which works or helps.
A large distance between a computer model and a cure.
Bluntly:
This is stupid.
7yeah but with someghung as devestating as alzheimer’s ill go with the hope that it will work. At worst, it wont work for alzheimer’s but will help other things. If it does work, thatm is just a bonus.
I am with you on this.
Alzheimers is just one form of dementia. Will this lead to a cure for other forms of this condition?
This will be known as the era of mouse and rat medicine. We’ve done an amazing amount for rodents in the last 70 years.
It was two mouse models with pathologies the same as humans.
It doesn't hurt to try a small dose of a common supplement for awhile to see if it can help, especially when AD has the NAD+ problem the precursors already can address.
Follow
How would you address the NAD+ problem?
You can wait a decade or two, or simply see if it helps, today.
Korsakov’s syndrome looks like Alzheimers but it’s caused by drinking too much and frying your brain. My glamourous mother had this and had to be moved to a locked facility.
You’re overthinking it and falling for so-called ‘research’ BS.
Bookmarked.
I have no functioning CYP2D6. Despite the many studies on this enzyme it is not quite clear how many toxins and how much are accumulating in my brain because of it.
I am also gstt1null. Another toxin issue
To say Nad + couldn’t possibly help my brain is just something you don’t know.
Why Diterpenes Are Not NAD+ Precursors
Diterpenes have entirely different structures and metabolic fates. Their metabolism involves Phase I reactions (primarily hydroxylation and oxidation) and Phase II conjugation reactions with glucuronic acid, cysteine, or methylation—processes completely unrelated to the nicotinamide-based biosynthetic pathways that generate NAD+. There is no biochemical mechanism by which diterpenes could serve as substrates for NAD+ synthesis.
If you’ve encountered information suggesting diterpenes support NAD+ metabolism, it may be confusing their general antioxidant and mitochondrial support effects with direct NAD+ precursor activity—a critical distinction in cellular biochemistry.
What I do know: An entire industry is built upon the false premise of a cure for a modern disease of epidemic proportions and they have accomplished squat for all the $$ & volunteer efforts.
Except, of course, for a boatload of disillusionment. I am personally privy to the scam nature of Alzheimer’s fundraising; regrettably their so-called research follows a predictable narrative. The red flag here: Claims of ‘repair’. A tell. THE tell.
Tragic that you have what may be a genetic anomaly, but you should look to other researchers for help, not any associated with ‘Alzheimer’s’ research.
Free advice.
I started taking a NAD supplement about a month ago. Not because I have Alzheimer, I don’t, but because it’s suppose to fix the body’s repair system, which help fix or prevent the overall body damage that comes with age.
I read about it from a book by Tony Robbins - “Life Force”. Quite an interesting book about cutting edge medicine. NAD is one of the many topics he covers.
Since I’m getting old with a few old age ailments here and there, I figure I’d give it a try and if anything happens.
Has anybody else here tried a NAD supplement?
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