Maybe stop feeding him seafood...ya think?
Now he’ll never come out of his shell.
Sidebar: Brave search AI results, “hereditary disease descendants of portuguese sailor”
The hereditary disease affecting the descendants of Portuguese sailor Antone Joseph, who settled in California in 1845, is a rare, fatal, autosomal dominant neurodegenerative disorder that was later identified as Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3).
The disease was first described in families from São Miguel Island in the Azores, Portugal, in 1972, and the Joseph family in California was among those diagnosed with the condition.
The disease, which began with Antone Joseph and has been passed down through generations, is characterized by progressive neurological deterioration, including impaired coordination, muscle stiffness, slurred speech, and difficulty swallowing, ultimately leading to death from pneumonia.
Symptoms typically begin in the early 30s, though they can appear as early as age 15 or as late as 45, and the disease progresses over about 20 years.
In 1975, nearly 100 descendants of Antone Joseph gathered at Oakland Children’s Hospital in California for genetic counseling and neurological exams conducted by Dr. William L. Nyhan and Dr. Roger Rosenberg, who named the condition striato nigral disease.
The family had long suffered from the disease without a proper diagnosis, often misattributed to other conditions like ataxia or even syphilis, and the condition was shrouded in secrecy and stigma.
Genetic research indicates that Machado–Joseph disease has multiple origins, with founder effects in the Azores, Japan, Brazil, and France, and the Azorean variant is linked to a mutation on chromosome 14q24.3–32.
The Joseph family’s lineage is believed to have originated from Portugal’s northeast, possibly involving Sephardic Jewish populations, and the disease spread through migration, including to New England and California.
Despite the lack of a cure, the 1975 gathering marked a pivotal moment in the family’s history, enabling genetic awareness and counseling for future generations.
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Ahhh ... so many horribly crude directions I could go with this ...
All the cats in the world probably said PURRRRRRRFECT when they read this.
“Doc, it hurts when I go like this.”
Doc: “Don’t go like this..”
What did the blind man say as he walked through the fish market?
Good morning, ladies...
Reminds me of a woman where I worked would reek of nicotine every time she came in from having a cigarette. Came out her pores I guess.
Fresh fish doesn’t smell.
A Pied Piper for CATS!