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One dose of antibiotic treats early syphilis as well as three doses, clinical trial shows
Medical Xpress / National Institutes of Health / New England Journal of Medicine ^ | Sept. 3, 2025 | Edward W. Hook III, M.D. et al

Posted on 09/21/2025 7:01:21 PM PDT by ConservativeMind

Researchers have found that a single injection of the antibiotic benzathine penicillin G (BPG) successfully treated early syphilis just as well as the three-injection regimen used by many clinicians in the United States and elsewhere. These findings from a late-stage clinical trial suggest the second and third doses of conventional BPG therapy do not provide a health benefit.

Syphilis is a common sexually transmitted infection (STI) caused by the bacterium Treponema pallidum.

Without treatment, syphilis can result in neurological and organ damage as well as severe pregnancy complications and congenital abnormalities. Syphilis can also increase a person's likelihood of acquiring or transmitting HIV.

BPG is one of the few antibiotics known to effectively treat syphilis, and stockouts are common worldwide.

The study was conducted at 10 U.S. sites and enrolled 249 participants with early syphilis, which encompasses the primary, secondary, and early latent stages of disease; 61% of participants were living with HIV and 97% were men.

The participants were randomly assigned to receive either a single intramuscular (IM) injection of BPG 2.4 million units (MU) or a series of three IM injections of BPG 2.4 MU at weekly intervals. All participants were monitored for safety. Biological markers of successful treatment in the blood—known as the serologic response to therapy—were examined at six months following treatment.

Some 76% of participants in the single-dose group had a serologic response to treatment compared to 70% of participants in the three-dose group. The difference between groups was not statistically significant, even when participants were stratified by HIV status.

According to the study authors, the results from this trial provide substantial evidence that single-dose BPG 2.4 MU is as effective as three doses in treating early syphilis.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: billclinton
One dose of benzathine penicillin G (BPG) does as well as three.

Getting rid of syphilis was only a partial help, for those on the study who also had AIDS.

1 posted on 09/21/2025 7:01:21 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 09/21/2025 7:02:03 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Is it too late to help Bill Clinton?


3 posted on 09/21/2025 7:04:19 PM PDT by LeonardFMason
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To: ConservativeMind

An ounce of prevention is worth a pound of cure.


4 posted on 09/21/2025 7:06:55 PM PDT by Flag_This (They're lying.)
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To: ConservativeMind
American doctors notoriously overdose everything. Guidelines often don’t leave room to vary starting dosages based on weight, gender… 🤦🏻‍♀️

And then when that doesn’t work, you have the opposite extreme happen where now some just flat out refuse antibiotics as the first course of action for fear of resistance or abuse. 🤦🏻‍♀️

It’s like just start low, go slow, and have a limit! Like “5 day course.” 🙄

5 posted on 09/21/2025 7:08:06 PM PDT by CondoleezzaProtege
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To: All

ah no problem, i’m sure the companies will increase the price 3x to fix this mistake.


6 posted on 09/21/2025 7:08:16 PM PDT by VAFreedom (Wuhan Pneumonia-Made by CCP, Copyright Xi Jingping)
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To: LeonardFMason
I knew I’d strike comedy gold in these comments. 😆
7 posted on 09/21/2025 7:23:19 PM PDT by TXBlair (Temp tagline: Je suis Charlie. 9.10.25 May the good Lord receive and embrace you, Mr. Kirk.)
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To: ConservativeMind

Some of the problem with vaccines isn’t even the concept itself — it’s the dosage, or doing one too many shots at any given moment instead of spacing out. Babies ESPECIALLY should only be recommended the barest minimum.

- “Delaying a COVID vaccine’s second dose boosts immune response”
- “Older people who waited 11–12 weeks for their second jab had higher peak antibody levels than did those who waited only 3 weeks.”
https://www.nature.com/articles/d41586-021-01299-y

“FDA approves Moderna’s new lower-dose COVID-19 vaccine”
https://apnews.com/article/covid19-moderna-vaccine-fda-84293ee6799dfbbe4e66dce06022afae


8 posted on 09/21/2025 7:23:27 PM PDT by CondoleezzaProtege
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To: CondoleezzaProtege

Having money is like having syphilis. Ya don’t go tellin’ everybody about it.


9 posted on 09/21/2025 7:56:05 PM PDT by DIRTYSECRET
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To: ConservativeMind

HFMMY


10 posted on 09/21/2025 8:33:43 PM PDT by kiryandil (No one in AZ that voted for Trump voted for Gallego )
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To: ConservativeMind

But they make more money on three doses, and isn’t that the point?


11 posted on 09/21/2025 8:38:05 PM PDT by nickcarraway
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To: ConservativeMind
Things I don't have reason to worry about.

12 posted on 09/21/2025 8:46:32 PM PDT by Governor Dinwiddie ( O give thanks unto the Lord, for He is gracious, and his mercy endures forever. — Psalm 106)
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To: ConservativeMind

there is some evidence that AIDS is not caused by the hiv virus, and Fauci lied about it.

The Duesberg hypothesis was developed by American biologist Peter Duesberg who argued AIDS was caused by noninfectious factors, such as recreational and pharmaceutical drug use, and that HIV is merely a harmless passenger virus.

AIDS is caused by other factors. Some denialists suggest that AIDS is not an infectious disease but is caused by other factors, such as drug use, malnutrition, or exposure to toxins.

Some say antiretroviral drugs are poisonous. A core tenet of their denialism is the belief that the life-saving antiretroviral drugs used to treat HIV are, in fact, poisons that cause AIDS.

https://ia903203.us.archive.org/1/items/syphilis-aids-hypothesis-books/syphilisasaids-robert-mitchell-1990.pdf


13 posted on 09/21/2025 9:30:20 PM PDT by algore
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To: ConservativeMind
They sayin' my chamomile tea cure's not good enough?

Regards,

14 posted on 09/22/2025 8:04:42 AM PDT by alexander_busek (Extraordinary claims require extraordinary evidence.)
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