Posted on 08/23/2025 4:12:56 PM PDT by ConservativeMind
Researchers have uncovered a novel link between gut microbiota-derived palmitic acid (PA) and increased thrombosis risk in cardiovascular disease (CVD).
Their findings reveal how a high-fat diet elevates circulating PA via gut bacteria and induces hypercoagulation.
Studies link gut microbiota to CVD. Host diet and macronutrients are key mediators that link the interactions between host and gut microbiota. Circulating palmitic acid (PA) primarily originates from diet and endogenous synthesis, and an elevated level is typically correlated with an increased risk of CVD.
In this study, the researchers found significantly higher levels of circulating PA and hypercoagulable states in patients with CVD compared to healthy controls.
Furthermore, the relative abundance of BT was significantly higher in the CVD group, showing an approximate 2.18-fold increase compared to the healthy control group.
By screening the effect of PA on coagulant and anticoagulant proteins, the researchers found that PA acts as an inhibitor of APC, which is a key component in a physiological anticoagulant system. In addition, PA promotes platelet activation, which may subsequently affect platelet-mediated thrombosis. The procoagulant ability of PA was further confirmed in mouse models.
Then they analyzed the metabolites of gut BT strains and found that the BT strains could produce PA in vitro. Mice colonized with BT exhibited elevated plasma PA levels and a corresponding hypercoagulable state, suggesting a causal role of this gut microbe in modulating host thrombosis risk.
Dietary habits of the host directly impact the composition and function of the gut microbiome. Notably, a high-fat diet promoted the colonization of BT in the host, increased plasma PA levels of the host, and then induced hypercoagulation.
Hesperidin, an abundant and economical dietary bioflavonoid, blocks the PA-APC interaction, preventing hypercoagulation induced by PA or BT transplantation. This reveals a novel anticoagulation mechanism of this dietary compound.
(Excerpt) Read more at medicalxpress.com ...
The high fat / high carb diet causes increased blood clotting, which appears to be reversed when getting sources of hesperidin.
Good sources of hesperidin are the white peel parts of oranges, limes, and lemons, but it’s also available in supplements.
I would guess most people eating the Standard American Diet are not volunteering to eat the bitter white peel parts of citrus fruits, often.
My wife does, but we also don’t eat the SAD way.
Review
The SAD diet, or Standard American Diet, is characterized by high consumption of processed foods, refined grains, red and processed meats, sugary drinks, and low intake of fruits, vegetables, and whole grains. This dietary pattern is associated with increased risks of obesity and cardiovascular diseases.
You completely left out the high fat side of the diet.
The Standard American diet has fried foods, high fat dairy and other fat food sources.
I am not sure how you missed that.
I didn’t recognize “SAD” so looked it up and copy/pasted the AI answer.
AI always needs to be sanity checked.
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